Item Number: RYCARFAI
Dogs: For the control of post-operative pain and inflammation following orthopaedic and soft tissue (including intraocular) surgery.
Cats: For the control of post-operative pain following surgery.
Dosage and administration
Dogs: The recommended dosage is 4.0 mg carprofen/kg bodyweight (1 ml/12.5 kg bodyweight), by intravenous or subcutaneous injection. The product is best given pre-operatively, either at the time of premedication or induction of anaesthesia.
Cats: The recommended dosage is 4.0 mg/kg (0.24 ml/3.0 kg bodyweight), by subcutaneous or intravenous injection, best given pre-operatively at the time of induction of anaesthesia. The use of a 1 ml graduated syringe is recommended to measure the dose accurately.
Clinical trial evidence in dogs and cats suggests only a single dose of carprofen is required in the first 24 hours perioperatively; if further analgesia is required in this period a half dose (2 mg/kg) of carprofen may be given to dogs (but not to cats) as necessary.
In dogs, to extend analgesic and anti-inflammatory cover post-operatively, parenteral therapy may be followed with carprofen tablets at 4 mg/kg/day for up to 5 days.
For administration of the product a 21-gauge needle should be used.
The cap can be punctured up to 20 times. When puncturing more than 20 times, use a draw-off needle.
Typical undesirable effects associated with NSAIDs such as vomiting, soft faeces/diarrhea, faecal occult blood, loss of appetite and lethargy have been reported. These adverse reactions occur generally within the first treatment week and are in most cases transient and disappear following termination of the treatment but in very rare cases may be serious or fatal.
If adverse reactions occur, use of the product should be stopped and he advice of a veterinarian should be sought.
Special precautions for use in animals
Do not exceed the recommended dose or duration of treatment.
Due to the longer half life in cats and narrower therapeutic index, particular care should be taken not to exceed the recommended dose and the dose should not be repeated.
Use in aged dogs and cats may involve additional risk.
If such use cannot be avoided, such animals may require a reduced dosage and careful clinical management.
Avoid use in any dehydrated, hypovolaemic or hypotensive animals, as there is a potential risk of increased renal toxicity.
NSAIDs can cause inhibition of phagocytosis and hence in the treatment of inflammatory conditions associated with bacterial infection, appropriate concurrent antimicrobial therapy should be instigated.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Care should be taken to avoid accidental self-injection.
Carprofen, in common with other NSAIDs, has been shown to exhibit photosensitising potential in laboratory animals. Avoid skin contact with the product. Should this occur, wash the affected area immediately.
As with other NSAIDs there is a risk of rare renal or idiosyncratic hepatic adverse events.
Use during pregnancy, lactation and lay
Laboratory studies in laboratory animals (rat, rabbit) have shown evidence of foetotoxic effects of carprofen at doses close to the therapeutic dose.
The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Do not use in dogs or cats during pregnancy or lactation.
Contra-indications, warnings, etc
Do not use in animals suffering from cardiac, hepatic or renal disease or gastrointestinal problems, where there is a possibility of gastrointestinal ulceration or bleeding, or hypersensitivity to carprofen or any other NSAIDs or any excipients of this product.
Do not administer by intramuscular injection.
Do not use after surgery which was associated with considerable blood loss.
Do not use in cats on repeated occasions.
Do not use in cats less than 5 months of age.
Do not use in dogs less than 10 weeks of age.
Occasionally reactions at the injection site may be observed following subcutaneous injection.
There is no specific antidote for carprofen overdosage but general supportive therapy as applied to clinical overdosage with NSAIDs should be applied.
Do not administer other NSAIDs and glucocorticoids concurrently or within 24 hours of administration of the product. Carprofen is highly bound to plasma proteins and may compete with other highly bound drugs, which can lead to toxic effects.
Concurrent administration of potential nephrotoxic drugs should be avoided.
In the absence of compatibility studies this veterinary medicinal product must not be mixed with other veterinary medicinal products.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
Store in a refrigerator (2°C – 8°C).
Do not freeze.
Once opened do not store above 25°C.
Type I glass vial (amber glass): 1 vial of 20 ml solution for injection with bromobutyl rubber stopper and aluminium seal, in a box.
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