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Intra-Epicaine 2.0% w/v Solution for Injection

Item Number: INTRAEPI

Intra-Epicaine 2.0% w/v Solution for Injection

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Description

Mepivacaine is indicated for infiltration, nerve block, intra-articular and epidural anaesthesia in horses.

Special precautions for use in animals

Care should be taken to avoid intra-vascular injection by aspiration prior to and during administration.

The analgesic effect of mepivacaine, when used as part of a lameness investigation, begins to subside after 45-60 minutes. However, sufficient analgesia may persist to affect gait beyond two hours.


Data Sheets

Intra-Epicaine 20 mg/ml Solution for Injection for Horses Species:Horses and other equidae

Therapeutic indication:Pharmaceuticals: Neurological preparations: Local anaesthetics

Active ingredient:Mepivacaine Hydrochloride

Product:Intra-Epicaine 20 mg/ml Solution for Injection for Horses

Product index:Intra-Epicaine 20 mg/ml Solution for Injection for Horses

Withdrawal notes:Not to be used in horses intended for human consumption. Treated horses may never be slaughtered for human consumption. The horse must have been declared as not intended for human consumption under national horse passport legislation.

Qualitative and quantitative composition

1 ml contains: Active substance:

Mepivacaine hydrochloride 20 mg

Pharmaceutical form

Solution for injection. A clear colourless mobile liquid, practically free from visible particles.

Clinical particulars

Target species

Horses.

Indications for use

Mepivacaine is indicated for infiltration, nerve block, intra-articular and epidural anaesthesia in horses.

Special precautions for use in animals

Care should be taken to avoid intra-vascular injection by aspiration prior to and during administration.

The analgesic effect of mepivacaine, when used as part of a lameness investigation, begins to subside after 45-60 minutes. However, sufficient analgesia may persist to affect gait beyond two hours.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Care should be taken to avoid accidental self-injection or skin contact. In the event of accidental self-injection medical advice should be sought. Wash splashes from skin or eyes immediately.

Adverse reactions

Transient, local soft tissue swelling may occur in a small proportion of cases following injection of the product.

Local anaesthetics used in excess can cause systemic toxicity characterised by CNS effects.

If systemic toxicity occurs, as a result of inadvertent intra-vascular injection, the administration of oxygen to treat cardio-respiratory depression and diazepam to control convulsions should be considered.

Use during pregnancy and lactation

Not contraindicated.

Amounts to be administered and administration route

Full aseptic precautions should be observed when injecting the product.

For infiltration: As required, but as a guide 2-5 ml.

For nerve block: 2-10 ml, depending on location.

For intra-articular anaesthesia: 5 ml.

For epidural anaesthesia: 4-10 ml, depending on the depth and extent of anaesthesia required.

In all instances the dosage should be kept to the minimum required to produce the desired effect. The depth and extent of anaesthesia should be determined by pressure with a blunt point, such as a tip of a ball point pen, before commencing manipulations.

The duration of action is about one hour.

It is recommended that the skin should be shaved and thoroughly disinfected prior to the intra-articular or epidural administration.

Overdose

Local anaesthetics used in excess can cause systemic toxicity characterised by CNS effects. If systemic toxicity occurs, as a result of inadvertent intra-vascular injection, the administration of oxygen to treat cardio-respiratory depression and diazepam to control convulsions should be considered.

Withdrawal periods

Not to be used in horses intended for human consumption. Treated horses may never be slaughtered for human consumption. The horse must have been declared as not intended for human consumption under national horse passport legislation.

Pharmacological particulars

Mepivacaine hydrochloride is a potent local anaesthetic, with a rapid onset of action. Since it does not cause vasodilation it does not require adrenaline to prolong its effect. Mepivacaine has been employed successfully for all types of local anaesthesia and is recommended for infiltration, nerve block, intra-articular and epidural anaesthesia in the horse.

ATCvet code: QN01BB03

Pharmacodynamic properties

The mechanism of action of mepivacaine is to prevent the generation and conduction of the nerve impulse. Conduction is blocked by decreasing or preventing the large transient increase in the permeability of excitable membranes to Na+ that is produced by a slight depolarisation. This action is due to a direct effect with voltage-sensitive Na+ channels. Mepivacaine exists in both charged and uncharged forms at physiological pH while the intracellular environment favours formation of the active, charged molecule. The onset of action of mepivacaine is, therefore, rapid (2-4 minutes) with an intermediate duration of action (about 1 hour).

Pharmacokinetic properties

Peak venous levels of mepivacaine have been measured in mares following caudal epidural anaesthesia or caudal subarachnoid anaesthesia. The maximum venous concentrations were similar (0.05 µg/ml) and were reached in 51-55 minutes. In a separate study, mepivacaine or its metabolites appeared in the urine within 15 minutes of subcutaneous injection and reached peak levels within 2-6 hours. It was largely cleared from the urine within 24 hours. The major metabolite in horse urine is 3-hydroxymepivacaine.

Pharmaceutical particulars

Incompatibilities

In the absence of compatibility studies, this veterinary medicinal product must not be mixed with any other veterinary medicinal product.

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 5 years.

This product does not contain an antimicrobial preservative. Once opened, use immediately. Discard any unused material.

Special precautions for storage

Do not store above 25°C.

Immediate packaging

Clear glass vials containing 10 ml, with a red chlorobutyl stopper and aluminium seals, are available in cartons of six.

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Dechra Limited, Snaygill Industrial Estate, Keighley Road, Skipton, North Yorkshire, BD23 2RW, United Kingdom.

Marketing Authorisation Number

Vm 10434/4016

Significant changes

Date of the first authorisation or date of renewal

20 December 1990

Date of revision of the text

August 2015

Any other information

For animal treatment only. To be supplied only on veterinary prescription. Keep out of the sight and reach of children.

Legal category

Legal category:POM-V

GTIN

GTIN description:Intra-Epicaine 20 mg/ml Solution for Injection:

GTIN:05701170422030

Delivery

Shipping charges mainland UK zone1

ValueWeightDelivery Charge
Over £49.00Any WeightFREE
Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

Returns

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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