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Depocillin Injection 100ml

Item Number: DEPOCIL

Depocillin Injection 100ml
  • 100ml

    Estimated dispatch on Friday

    £ 10.45

Total: £0.00

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You are ordering a PRESCRIPTION ONLY medicine. Please do NOT continue unless you are sending us a valid prescription.



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The treatment of infections caused by bacteria sensitive to penicillin in horses, cattle, sheep, pigs, dogs and cats.

Data Sheets

Depocillin® 300 mg/ml suspension for injection Species:Cats, Dogs, Horses and other equidae, Pigs, Sheep

Therapeutic indication:Pharmaceuticals: Antimicrobials: Injections

Active ingredient:Procaine Benzylpenicillin

Product:Depocillin® 300 mg/ml suspension for injection

Product index:Depocillin®

Cattle - milk:264 hours (11 days)

Cattle - meat:5 days

Sheep - meat:5 days

Pig - meat:5 days

Qualitative and quantitative composition

Active substance per ml:

Procaine benzylpenicillin 300 mg


Methylparahydroxybenzoate 1.10 mg

For the full list of excipients, see section “Pharmaceutical particulars”.

Pharmaceutical form

Suspension for injection

Clinical particulars

Target Species

Cow, horse, sheep, pig, dog and cat

Indications for use

Depocillin is indicated for the treatment of infections caused by bacteria sensitive to penicillin.


Not to be administered to animals sensitive to penicillin.

Not to be used in rabbits, guinea pigs, hamsters or gerbils. Caution is advised in its use in any other small herbivores.

Not effective against beta-lactamase producing organisms.

Special warnings for each target species

Occasionally in sucking and fattening pigs, administration of products containing procaine penicillin may cause a transient pyrexia, vomiting, shivering, listlessness and incoordination. Additionally in pregnant sows and gilts a vulval discharge which could be associated with abortion has been reported.

Special precautions for use

Not recommended for intravenous or intrathecal administration

Operator warnings

Penicillin and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillin may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances are occasionally serious.

1. Do not handle this product if you know you are sensitised or if you have been advised not to work with such preparations.

2. Handle this product with great care to avoid exposure, taking all recommended precautions.

3. If you develop symptoms following exposure, such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention.

Wash hands after use.

Adverse Reactions

Occasional allergies to penicillin have been observed but these are very rare.

Use during pregnancy or lactation

No special precautions necessary


Antagonism between the product and bacteriostatic preparations may occur.

Resistant bacteria, particularly gram-negative, that show a cross-resistance with other ß-lactam antibiotics might occur.

Amounts to be administered and administration route

Horses and cattle 12 mg/kg bodyweight, sheep and pigs 15 mg/kg by intramuscular injection

Dogs and cats 30 mg/kg (1ml per 10 kg body weight) by subcutaneous administration

Suggested doses are:

Horse 500 kg 20 ml

Cow 500 kg 20 ml

Sheep 50 kg 2.5 ml

Pig 50 kg 2.5 ml

Dog 10 kg 1 ml

Cat 5 kg 0.5 ml

Clean the area of the injection site and swab with spirit. Shake well before use.

Treatment may be repeated at 24 hour intervals for up to 5 administrations.

For organisms highly susceptible to penicillin, such as Streptococcus dysgalactiae in sheep, treatment may be repeated at 48 hour intervals for up to 3 administrations.


Do not inject more than 20 ml per injection site in cattle.

Do not inject more than 5 ml per injection site in pigs and sheep.


Penicillin is a compound with a very high therapeutic ratio. It is very unlikely that an overdose of the product will have adverse effects on the treated animal.

Withdrawal periods

Meat: Cattle 5 days

Pigs 5 days

Sheep 5 days

Milk: (Cows only) 264 hours (11 days)

Not to be used in sheep producing milk intended for human consumption.

Not to be used in horses intended for human consumption.

Treated horses may never be slaughtered for human consumption.

The horse must have been declared as not intended for human consumption under national horse passport legislation.

Pharmacological particulars

ATC Vet Code: QJ0ICE09

Pharmacotherapeutic group:

Antibacterials for systemic use, Beta-lactam antibacterials, penicillins, Beta-lactamase sensitive penicillins.

Pharmacokinetic particulars

Penicillin is a beta-lactam antibiotic which has bactericidal activity against mainly Gram-positive bacteria and some Gram-negative aerobes. It is sensitive to beta-lactamase (penicillinase) inactivation. It is widely distributed in the extracellular fluids after absorption, and eliminated almost entirely by the kidneys.

The procaine penicillin gives high initial blood levels; treatment may be repeated at 24 or 48 hour intervals to maintain therapeutic levels.

Pharmaceutical particulars


Methyl parahydroxybenzoate

Lecithin (soya)

Povidone (K30)

Sodium Citrate dihydrate

Potassium Acid Phosphate

Disodium Edetate Dihydrate

Sodium hydroxide 32% (for pH adjustment)

Phosphoric acid 85% (for pH adjustment)

Water for injections

Major incompatibilities

None known


Shelf life: 3 years

Following withdrawal of the first dose, use the product within 28 days.

Special precautions for storage

Store in a refrigerator at between +2oC and +8oC. Do not freeze. Protect from light.

Immediate packaging

Multidose vials of neutral (Ph.Eur. type II) glass or PET closed with halogenated butyl rubber stoppers and aluminium closures, containing 100 ml.


Any unused product or waste material should be disposed of in accordance with national requirements.

Marketing Authorisation Holder (if different from distributor)

Marketing Authorisation Number

UK: Vm 01708/4622

Significant changes

Date of the first authorisation or date of renewal

25 September 1996

Date of revision of the text

July 2020

Any other information

For animal treatment only. Keep out of the sight and reach of children.

Legal category

Legal category:POM-V


Shipping charges mainland UK zone1

ValueWeightDelivery Charge
Over £49.00Any WeightFREE
Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.


We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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