Item Number: CEPRAVIN
Presentation Cepravin Dry Cow is a long-acting intramammary suspension containing cefalonium, a semi-synthetic cefalosporin antibiotic. It is formulated to give persistent antibiotic levels in the dry udder. Effective levels of cefalonium are usually present in most quarters for up to 10 weeks after intramammary infusion at drying-off. Each single dose 3g syringe contains 250 mg cefalonium in a long-acting base. Uses Cepravin Dry Cow is recommended for routine dry cow therapy, to treat existing sub-clinical infections and to prevent new infections which occur during the dry period. Cefalonium is a broad spectrum cefalosporin antibiotic which has bactericidal activity against the majority of organisms associated with bovine mastitis. This antibacterial activity is not impaired in the presence of milk. Cefalonium is active against Staphylococcus aureus, including penicillin-resistant strains, Streptococcus agalactiae, Streptococcus dysgalactiae, Actinomyces pyogenes and Corynebacterium ulcerans. Strains of Strep. uberis and E. coli isolated from post-calving mastitis cases were sensitive to cefalonium. Cattle treated with Cepravin Dry Cow generally have a lower incidence of Streptococcus uberis infection during the dry period and the immediate post-calving period, with accompanying lower somatic cell counts. The antibiotic was also active against environmental organisms recovered from the bovine udder, including Proteus spp., Klebsiella spp., Citrobacter spp., and Enterobacter strains. Effective levels of cefalonium are maintained in most quarters for up to 10 weeks after infusion of Cepravin Dry Cow. Provided calving takes place 54 days or more after infusion, any antibiotic present at the end of the dry period is excreted within the first four days of lactation. Dosage and administration For intramammary infusion. The contents of one syringe should be infused into the teat canal of each quarter immediately after the last milking of the lactation. Before infusion, the teat should be thoroughly cleaned and disinfected. Avoid contamination of the nozzle after removing the cap After infusion it is advisable to dip the teats in an antiseptic preparation specifically designed for this purpose. Contra-indications, warnings, etc Must not be used in the lactating cow. Not intended for use within 54 days of calving. Operator warnings Penicillins and cephalosporins may cause sensitisation (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillin may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious. 1.Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations. 2.Handle this product with great care to avoid exposure taking all recommended precautions. If you develop symptoms following exposure such as a skin rash you should seek medical advice and show the Doctor this warning. Swelling of the face, lips or eyes or difficulty breathing are more serious symptoms and require urgent medical attention. Wash hands after use. Protection of Consumers Milk for human consumption may only be taken from 96 hours after calving. If calving occurs before 54 days after treatment, milk for human consumption may be taken after 54 days plus 96 hours after treatment, ensuring that the milk from at least 7 complete milkings is discarded. The absence of antibiotic should be confirmed by testing before the milk is used for human consumption. This is advisable because of variation in the milking cow's ability to excrete antibiotic from dry cow products. In cows suffering from hypocalcaemia, it may be necessary to discard milk for a longer period. Animals for human consumption should not be slaughtered until 21 days after last treatment. For animal treatment only. Keep out of the reach of children. Pharmaceutical precautions: The syringe must only be used once. Part syringes must be discarded. Dispose of any unused product and empty syringes in accordance with guidance from your local waste regulation authority. Do not store above 30°C. Avoid extremes of temperature during storage Legal category POM-V (previously POM) Packaging Quantities Boxes of 20 syringes, Herd Packs of 120 syringes, Dairy Packs of 160 syringes. Further information If the product is used in heifers during their first pregnancy the same precautions should be observed as in cows, i.e. infusions should be given no less than 54 days before calving and milk discarded for the statutory four days after calving. Summer Mastitis It is unlikely that antibiotic treatment alone will control Summer Mastitis and therefore other measures should be implemented as part of routine management. These measures include: 1.Practising some form of fly control on the farm. 2.Avoiding pasturing cattle on wet or wooded fields which are known to be associated with Summer Mastitis. 3.Post-infusion teat dipping of cows and heifers receiving prophylactic intramammary infusions for the disease . 4.Prompt attention to teat injuries or sores as these rapidly attract flies.
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