Protexin Pro-Enzorb is a supplement for dogs and cats which supports exocrine pancreatic function. It contains an active blend of three pancreatic enzymes - Lipase, Amylase and Protease, which are made into enterically-coated pellets which protect them from low pH levels in the stomach so they can reach the small intestine, where the digestive action is required.
The coated micro-pellets in Pro-Enzorb are not broken down
in the stomach, allowing them to reach the duodenum, where the digestive enzymes are released to aid food digestion.
Exocrine Pancreatic Insufficiency (EPI) is a syndrome caused
by insufficient synthesis and secretion of pancreatic enzymes.Maldigestion occurs when pancreatic enzyme activity is reduced. Undigested food components in the intestinal lumen result in diarrhoea, changes to the intestinal microflora and weight loss.
The main clinical signs associated
with EPI include:
• Weight loss
• Loose faeces – voluminous,
• Changes in appetite –
polyphagia, scavenging, coprophagia, pica
• Poor hair coat, flatulence, borborygmi
Common complications associated with EPI include a reduction
in serum cobalamin (Vitamin B12) and a dysbiosis of the
intestinal bacterial flora.
Cyanocobalamin (Vitamin B12) in the diet combines with
gastric or pancreatic intrinsic factor to aid absorption from
the intestinal tract into the bloodstream. 82% of dogs with
EPI are hypocobalaminemic due to a deficiency in production
of pancreatic intrinsic factor by acinar cells.
Veterinarians are advised to supplement parentally in all
cases presenting with hypocobalaminemia. Pro-Enzorb
contains high levels of cyanocobalamin to support the
maintenance of normocobalamin serum levels. Despite a
lack of pancreatic intrinsic factor, dogs with EPI are able to
complex oral cyanocobalamin with gastric intrinsic factor and
hyper-supplementation aids an intrinsic factor independent
absorption mechanism. High dose oral cobalamin supplementation has been shown to normalise serum levels
in hypocobalaminemic dogs with chronic enteropathies
Intestinal bacterial dysbiosis is common in animals with EPI not
only before enzyme replacement treatment has been started
but during treatment as well.
Intestinal dysbiosis occurs due to an increased presence of
undigested food in the intestinal lumen, a lack of bacteriostatic
factors in the pancreatic juice, and changes in intestinal motility and immune functions.
The supplementation of pancreatic enzymes does not affect the occurrence of intestinal dysbiosis and oral antibiotic therapy is often required to control the intestinal microflora. Probiotics aim to regulate the intestinal microflora and reduce the level of bacterial dysbiosis.
Directions for use:
DO NOT ADMINISTER CAPSULES WHOLE.
Capsules should be opened and the contents carefully mixed with food. The total daily amount should be divided equally between feeds. The dose may be adjusted to achieve normal faecal consistency and/or appropriate weight gain.
Note that the powder can be an irritant. It is advisable to wear gloves and wash hands after administration of the capsules.
Each capsule contains:
• 480mg Pancreatin enteric-coated micro-pellets
° Lipase – 27,050 Ph. Eur. U. (minimum)
° Amylase – 22,604 Ph. Eur. U. (minimum)
° Protease – 1,325 Ph. Eur. U. (minimum)
• Enterococcus faecium (NCIMB 10415) E1707 – 1 x 108 CFU
• Cyanocobalamin (Vitamin B12) – >1mg
Body weight* Number of capsules per day
<20kg 1 capsule
>20kg 2 capsules
Gut Flora Stabilisers
Enterrococcus faecium (DSM 10663/NCIMB 10415) 4b1707
2 x 1011 CFU/kg; 2 x 108 CFU/g
Vitamin B12 (Cyanocobalamin)
Each capsule contains:
Lipase – 29,000 Ph. Eur. U. (minimum)
Amylase – 22,604 Ph. Eur. U. (minimum)
Protease – 1,450 Ph. Eur. U. (minimum)
Cyanocobalamin (Vitamin B12) – >1mg
Crude Protein 60%
Crude Fibre <0.1%
Acid insoluble ash 6%
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