Enterisol Ileitis lyophilisate and diluent for oral suspension for pigs.
Lyophilisate and diluent for oral suspension for pigs.
One 2 ml dose of reconstituted vaccine contains Lawsonia intracellularis. At least 1 x 10 4.9 TCID*50 Maximum 1 x 10 6.1 TCID*50( *Tissue Culture Infective Dose)
For active immunisation of weaned pigs from three weeks of age to reduce intestinal lesions caused by Lawsonia intracellularis infection and to reduce growth variability and impairment of weight gain associated with the disease. Under field conditions, the improvement in average daily weight gain (ADG) was seen to be up to 30g/day when vaccinated pigs were compared to non-vaccinates. Onset of protection occurs as early as three weeks post vaccination and lasts for at least 17 weeks.
Dosage and administration
All materials used in administering the vaccine must be free of antimicrobials, detergent or disinfectant residues to prevent inactivation.
Reconstitution with diluent:
10 and 50 dose presentation: Reconstitute the vaccine by adding the full content of the accompanying diluent to the vaccine. Shake well and use immediately.
100 dose presentation: Reconstitute the vaccine by adding half of the content of the accompanying diluent to the vaccine. Shake well and transfer the suspension back into the diluent bottle, mix with the remaining diluent to make up the full amount of 200 ml. Shake well and use immediately.
Vaccination by drench application:
Administer a single 2 ml dose orally to pigs (from three weeks of age), irrespective of body weight.
Vaccination via the drinking water:
Water systems have to be cleaned and rinsed with untreated water to eliminate residues of antimicrobials, detergents or disinfectants. The final solution containing the vaccine should be consumed within four hours after preparation. Calculate the number of vials required to vaccinate all the pigs according to the table below:
No of Pigs
10 dose (20ml)
50 dose (100ml)
100 dose (100ml)
Dilute the vaccine in the drinking water which will be consumed during a four hour time period. This should be calculated on the basis of the water intake observed during a four hour period at the time of planned vaccination on the previous day. Pigs will generally drink 8 to 12% of their body weight per day, depending on environmental temperatures. The actual amount of water consumed may vary considerably depending on several factors. It is essential for the efficacy of the product that pigs receive at least the recommended dose.
It is recommended to add skimmed milk powder or sodium thiosulfate solution as a stabiliser into the drinking water prior to adding the vaccine. The final concentration of the skimmed milk powder should be 2.5g/litre The final concentration of sodium thiosulfate should be approximately 0.055g/l.
After filling of the calculated water amount into the trough, sodium thiosulphate or skimmed milk powder should be added to the water. Afterwards, the vaccine is to be diluted either in the water / skimmed milk or in the water / thiosulphate mixture in the trough.
Contra-indications, warnings, etc
None known. Do not mix with any other veterinary medicinal product. No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis. Avoid accidental contact with skin. In the event of accidental skin contact, wash with soap or antibacterial wash and rinse well. No adverse reactions were observed after administration of the vaccine in breeding and pregnant animals. Vaccinate only clinically healthy animals. In case of anaphylactic reactions, appropriate symptomatic treatment including the administration of glucocorticoids, adrenaline, or antihistaminics is recommended.
Special warnings: The vaccine has not been tested in breeding boars, therefore do not vaccinate breeding boars. Do not vaccinate animals which are receiving treatment with antimicrobials effective against Lawsonia spp. Such antimicrobials should be withheld for a minimum of three days before and three days after the day of vaccination. The vaccine is an attenuated live vaccine and the potential for spreading to non-vaccinated animals cannot be excluded. However, based on the studies conducted with sentinel pigs, the apparent frequency of spreading and associated risk is very low. Lawsonia intracellularis DNA could be detected up to three days post vaccination in faecal samples of more than half of vaccinated animals, therefore transmission to pen-mates can not be excluded in this time period. Efficacy of revaccination is unknown.
Store and transport between +2ºC and +8ºC. Do not freeze.
Use immediately after reconstitution
Administration of the vaccine should be completed within four hours.
Keep out the reach and sight of children
For animal treatment only
Type 1 amber glass vial of 20 ml (10 doses), 100 ml (50, 100 doses) and
12 x 100 ml (12 x 100 doses) closed with a bromobutyl stopper with lacquered aluminium seal.
Type 1 clear glass vial containing 20 ml (10 doses), 100 ml (50 doses),
200 ml (100 doses) and 12 x 200 ml (12 x 100 doses) closed with a chlorobutyl stopper with lacquered aluminium seal.
High density polyethylene vial containing 20 ml (10 doses), 100 ml (50 doses), 200 ml (100 doses) and 12 x 200 ml (12 x 100 doses) closed with a chlorobutyl stopper with lacquered aluminium seal.
Not all pack sizes may be marketed.
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