Canixin DHPPi/L Suspension for Injection for Dogs (50 dose).
Indications for use
For active immunisation of dogs from 8 weeks of age to:
-prevent mortality and clinical signs of canine distemper and infectious canine hepatitis caused by canine adenovirus type 1;
-prevent mortality and clinical signs and reduce excretion caused by canine parvovirus in a challenge study performed with a CPV2b strain;
-reduce respiratory clinical signs caused by canine parainfluenza virus;
-prevent mortality and reduce infection, clinical signs, kidney colonisation, renal lesions and urine shedding of L. canicola and L. icterohaemorrhagiae;
The onset of immunity has been demonstrated from 3 weeks after the primary vaccination for CDV and CPV, 4 weeks for CAV-1 and CPIV, 5 weeks for L. canicola and 2 weeks for L. icterohaemorrhagiae.
The duration of immunity lasts for one year after the primary vaccination for all components. For CAV-2 and CPV components, the duration of immunity was demonstrated by serological data.
Special warnings for each target species
After vaccination, the live viral vaccinal strains (CAV-2, CPV) can be spread to unvaccinated animals without any pathological effect for these in-contact animals.
The presence of maternally derived antibodies (puppies from vaccinated females) can interfere with the vaccination. Therefore the vaccination scheme should be adapted accordingly (see section 4.9).
Special precautions for use
i. Special precautions for use in animals
Vaccinate only healthy animals
ii.Special precautions to be taken by the person administering the veterinary medicinal product to animals
-In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician.
After the administration of one dose of DHPPi/L vaccine most of the animals may exhibit a mild and transient swelling ( = 4 cm) or slight diffuse local oedema. This reaction resolves spontaneously within 1 to 12 days. In very rare cases pain and pruritus may occur. However these small transient injection site reactions resolve without treatment.
In very rare cases, the vaccination can induce a transient diarrhoea, hyperthermia or weakness. Hypersensibility reactions can be sometimes observed. In case of allergic or anaphylactic reaction, appropriate symptomatic treatment should be administered.
Use during pregnancy, lactation or lay
Do not use during pregnancy and lactation.
No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be decided on a case by case basis.
Amounts to be administered and administration route
After reconstitution of the lyophilisate with the solvent, shake gently and administer immediately one dose of 1 ml subcutaneously according to the following vaccination schedule:
Primary vaccination course :
- first injection from 8 weeks of age
- second injection 3 or 4 weeks later.
One booster injection of a single dose should be given 1 year after the second injection and annually thereafter.
Maternally derived antibodies can negatively influence the immune response to vaccination. In these cases, a third injection is recommended from 15 weeks of age.
The 10 doses administration of the vaccine in one single injection site showed no other reactions than those mentioned in the section “Adverse reactions” except for the duration of the local reactions (up to 26 days).
-ATCvet code QI07AI02
-To stimulate active immunity against canine distemper virus, canine adenovirus, canine parvovirus, canine parainfluenza virus and L. interrogans serogroup canicola and L. interrogans serogroup icterohaemorrhagiae
Potassium dihydrogen phosphate
Water for injections
Disodium phosphate anhydrous
Potassium dihydrogen phosphate
Water for injections
Do no mix the vaccine with any other veterinary medicinal product.
Shelf-life of the veterinary medicinal product as packaged for sale: 2 years.
Shelf-life after reconstitution according to directions: use immediately after reconstitution.
Special precautions for storage
Store and transport refrigerated (2°C – 8°C)
Protect from light
Do not freeze
Type I glass Vial
Any unused product or waste material should be disposed of in accordance with the local requirements.
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