Free UK Delivery on orders over £49

Zoletil 100 solution for injection for Cats and Dogs 5ml

Item Number: ZOLETILS

Zoletil 100 solution for injection for Cats and Dogs 5ml
  • 5ml

    Estimated dispatch on Thursday

    £ 68.29

Total: £0.00

Choose quantity to add to basket

You are ordering a PRESCRIPTION ONLY medicine. Please do NOT continue unless you are sending us a valid prescription.



Browse other products from the Virbac product range


Zoletil 100 solution for injection for Cats and Dogs 5ml.

Target species
Dogs and cats.
Indications for use, specifying the target species
General anaesthesia.

Do not use in cases of hypersensitivity to the active substances, or to any of the excipients.
Do not use the product in animals with severe cardiac or respiratory disease, or in animals with renal, pancreatic or hepatic insufficiency.
Do not use the product in the event of severe hypertension.
Do not use in rabbits.
Do not use in patients with head trauma or intracranial tumours.
Do not use for caesarean section.
Do not use in pregnant bitches and queens.

Special warnings for each target species
In dogs, since zolazepam is eliminated more quickly than tiletamine, there is a shorter duration of tranquilisation than there is of anaesthesia.

Special precautions for use
i) Special precautions for use in animals
Animals should be fasted for 12 hours prior to anaesthesia.
Remove anti-parasite collar 24 hours before anaesthesia.
If necessary, hypersalivation can be controlled with the administration of anticholinergic agents, such as atropine, before the anaesthesia according to a benefit/risk assessment by the responsible veterinarian.
Please refer to section “Interaction with other medicinal products and other forms of interaction” in case of the use of pre-anaesthetic agents.
Keep anaesthetised animals away from excessive noise and visual stimuli.
Apneustic breathing may be observed more commonly in cats after intravenous injection than after intramuscular injection. Especially for high dosages, such abnormal breathing patterns last for up to 15 minutes and then breathing returns to normal. In case of prolonged apnea respiratory assistance should be provided.
Close observation of dogs during the first 5-10 minutes after induction is recommended especially in animals with cardiopulmonary disease.
The product may cause hypothermia, in susceptible animals (small body surface area, low ambient temperature) supplemental heat should be applied if needed.
In dogs and cats the eyes remain open after receiving the product and should be protected from injury and excessive drying of the cornea.

Dosage may need to be reduced in geriatric, debilitated, or animals with renal dysfunction.
Reflexes (e.g. palpebral, pedal, laryngeal) are not abolished during anaesthesia and therefore use of this product alone may not be adequate if surgery is performed on these areas.
Redosing may prolong and worsen recovery.
In the event of reinjections, side effects (hyper-reflexia, neurological problems) can be produced due to tiletamine. It is recommended that the recovery phase occurs in a calm environment.
ii) Special precautions to be taken by the person administering the veterinary medicinal product to animals
In cases of accidental self-injection seek medical advice immediately and show the package leaflet or the label to the physician. Do not drive due to risk of sedation.
Wash splashes from skin and eyes immediately. In case of eye irritation, seek medical advice.
Wash hands after use.
This product may cross the placenta and be harmful to the foetus, therefore women who are pregnant, or are suspected to be pregnant, should not use the product.

Adverse reactions (frequency and seriousness)
Upon injection, pain has sometimes been reported in cats.
Very rare (less than 1 animals in 10 000 animals, including isolated reports) cases of neurological signs (prostrations, convulsions, coma, …) associated or not with cardio-respiratory signs (dyspnoea, tachypnoea, bradypnoea, tachycardia, cyanosis, … that can appear from 20 mg/kg in dogs) and some systemic signs (hypothermia, hyperthermia, pupillary disorders, hypersalivation, hypersensitivity towards external stimuli, agitation, vocalisation) have been observed principally during the awakening phase in the dog and during the surgery and the awakening phase in the cat.
In the recovery phase, it is possible to observe prolonged anaesthesia and difficulties awakening (myoclonus, restlessness, ataxia, paresis, etc.). All reactions are reversible and disappear once the active substance is eliminated from the body.

Use during pregnancy, lactation or lay
Studies conducted on laboratory animals did not reveal any teratogenic effect.
The product crosses the placenta and may cause respiratory depression in newborns that can be fatal for puppies and kittens. The safety of the product during pregnancy or lactation has not been established.
Use only accordingly to the benefit/risk assessment by the responsible veterinarian.
Interaction with other medicinal products and other forms of interaction
The benefit-risk assessment for using the product with other pre-anaesthetic or anaesthetic agents must take into consideration the dosages of the agents used, the nature of the intervention and the ASA (American Society of Anaesthesiologists) class to which the animal belongs. The required dosage of tiletamine-zolazepam is likely to change depending on which agents are concurrently used.
The dosage of tiletamine – zolazepam may need to be reduced when used concomitantly with pre-anaesthetic and other anaesthetic agents. Premedication with phenothiazine tranquilisers (e.g. acepromazine) can cause increased cardio-respiratory depression and an increased hypothermic effect that occurs in the last phase of anaesthesia.
Do not use medications containing chloramphenicol during the pre- or intra-operative period, as this slows down elimination of the anaesthetics.

Amounts to be administered and administration route
Intramuscular or intravenous use.

The content of the lyophilisate vial is to be diluted in 5 ml of the attached solvent.
The dosage is expressed in mg of the product, on the understanding that the reconstituted product is at a concentration of 100 mg per ml and contains 50 mg of tiletamine per ml and 50 mg of zolazepam per ml.
When the product is administered intramuscularly (unable to stand in 3 to 6 minutes) or intravenously (unable to stand in less than one minute), the recommended therapeutic dosages are the following:

Intramuscular route
Intravenous route
Testing and procedures causing little pain
7 to 10 mg/kg bw
5 mg/kg bw
Minor surgical procedures, anaesthesia of short duration
10 to 15 mg/kg bw
7.5 mg/kg bw
Painful interventions
15 - 25 mg/kg bw
10 mg/kg bw

Intramuscular route
Intravenous route
Tests and procedures causing little pain
10 mg/kg bw
5 mg/kg bw
Orthopaedic operation
15 mg/kg bw
7.5 mg/kg bw
Intravenous injections to be repeated, if needed, at between 1/3 and 1/2 of the initial dose but the total dosage should not exceed 26.4 mg/kg.

Dosage is based on species and on type of intervention; to be adjusted at the discretion of the practitioner based on the status of the subject (age, obesity, severe organic deficiencies, state of shock, debilitating diseases).

Duration of anaesthesia: 20 to 60 minutes depending on dose.
The product should not be used as sole anaesthetic agent for painful operations. For these operations the product should be combined with an appropriate analgesic.

Pre-surgical preparation:
As for all anaesthetics animals should be fasted for at least 12 hours before anaesthesia.
In dogs and cats, the use of atropine subcutaneously, 15 minutes before injection, may be considered.

Recovery period:
Analgesia lasts longer than surgical anaesthesia. Return to normal is progressive and can last 2 to 6 hours in a calm environment (avoid excessive noise and light). Recovery may be delayed due to an overdose in obese, old or debilitated animals.

Overdose (symptoms, emergency procedures, antidotes), if necessary
100 mg per kg constitutes a lethal dose for cats and dogs when administered intramuscularly, i.e., 5 to 10 times the anaesthetic dose. In the event of an overdose and in obese or old animals, recovery may be slower. Overdosed animals must be monitored carefully. The signs of overdosage are mainly cardio-respiratory depression that can appear from 20 mg/kg depending on the animal’s health, the level of central nervous system depression, and whether hypothermia is present. An earlier warning sign of overdosage is the loss of cranial and spinal reflexes. Prolongation of anaesthesia can be produced.
There is no specific antidote and treatment is symptomatic. Doxapram may have antagonistic activity against the tiletamine-zolazepam, increasing both heart and respiratory rates and reducing the arousal time.

Pharmacological particulars
Pharmacodynamic properties
Tiletamine is a compound belonging to the family of phencyclidines and is pharmacologically similar to ketamine. It antagonises NMDA-type receptors (N-methyl-D-aspartate) of the excitatory neurotransmitter, glutamic acid. It generates a so-called dissociative anaesthesia because it depresses certain cerebral regions such as the thalamus and the cortex whilst other regions, in particular the limbic system, remain active.
Zolazepam is a benzodiazepine and pharmacologically similar to diazepam. It has a sedative, anxiolytic and muscle-relaxing action.
Associations in proportions of 1/1 of two compounds with complementary actions enable the following effects:
- fast catalepsy, without agitation, followed by relaxation of the muscle,
- moderate superficial, immediate and visceral analgesia,
- surgical anaesthesia with muscle relaxation, preservation of laryngeal, pharyngeal and palpebral reflexes, without bulbar depression.Pharmacokinetic particulars
After intramuscular administration of 10 mg of tiletamine per kg and 10 mg of zolazepam per kg, the peak plasma concentrations of tiletamine and zolazepam (Cmax) are reached within 30 minutes in dogs and cats, indicating fast absorption.The terminal half-life of tiletamine (T1/2) is 2.5 hours in cats. It is shorter in dogs (1.2 to 1.3 hour).The terminal half-life of zolazepam is longer in cats (4.5hours) than in dogs (< 1 hour).Both active substances are extensively metabolised. Less than 4% of the dose is found in a non-metabolised form in urine and less than 0.3% in faeces.

Pharmaceutical particulars
List of excipients
Lyophilisate vial: - Sodium sulfate, anhydrous, Lactose monohydrate
Solvent vial:- Water for injections

In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

Shelf life
Shelf life of the lyophilisate as packaged for sale: 2 years.
Shelf life of the solvent as packaged for sale: 3 years.
Shelf life after reconstitution according to directions: 24 hours between +2°C and +8°C

Special precautions for storage
Keep the vials in the outer carton in order to protect from light.
After reconstitution, store in a refrigerator (2°C - 8°C).

Nature and composition of immediate packaging
Colourless Type 1 glass vial
Bromobutyle rubber stopper
Aluminium cap
Colourless Type 1 glass vial
Chlorobutyle rubber stopper
Aluminium cap

Pack size:
1 vial of 970 mg lyophilisate and 1 vial of 5 ml solvent
10 vials of 970 mg lyophilisate and 10 vials of 5 ml solvent
Not all pack sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Data Sheets

ZOLETILS: Data Sheet


Shipping charges mainland UK zone1

ValueWeightDelivery Charge
Over £49.00Any WeightFREE
Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.


We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

Frequently Asked Questions

There have been no questions/answers for this product so far.

Ask Question

Ask a question about Zoletil 100 solution for injection for Cats and Dogs 5ml


You Might Also Like

Chappie Original (6 x 412g)

Chappie Favourites Dog Food 412g x 6 cans. Chappie is a complete dog food for adult dogs and is easily digestible.


From £6.15 inc. VAT

Nimrod Red Start Paste 15.6g (Pack of 6 syringes)

Nimrod Red Start Paste 15.6g (Pack of 6 syringes). A paste to improve the survival of weak foals, calves and lambs - particularly those born in assisted deliveries or by Caesarean section.


From £35.39 inc. VAT