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Veloxa Chewable Dog Worming Tablets

Item Number: VELOXA

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Description

Each Veloxa chewable tablet contains:

Febantel 150 mg
Pyrantel 50 mg (corresponding to Pyrantel embonate 144 mg)
Praziquantel 50 mg

Chewable tablet. Brownish, oval, divisible chewable tablet. It can be divided into equal halves.

Broad-spectrum anthelmintic for treatment of mixed infections by the following roundworms and tapeworms in dogs and puppies:
Ascarids: Toxocara canis, Toxascaris leonina (adult and late immature forms). Hookworms: Uncinaria stenocephala, Ancylostoma caninum (adults). Whipworms: Trichuris vulpis (adults). Tapeworms: Echinococcus spp., Taenia spp. and Dipylidium caninum (adult and immature forms).

Use one tablet to 10kg bodyweight.


Data Sheets

VELOXA PK104: Data Sheet

Veloxa and Veloxa XL Chewable Tablets for Dogs Species:Dogs

Therapeutic indication:Pharmaceuticals: Endoparasiticides: Anthelmintics for dogs, Tapeworm products

Active ingredient:Febantel, Praziquantel, Pyrantel Embonate

Product:Veloxa Chewable Tablets for Dogs

Veloxa XL Chewable Tablets for Dogs

Product index:Veloxa

Qualitative and quantitative composition

Each Veloxa chewable tablet contains:

Active substances

Febantel 150 mg

Pyrantel 50 mg (corresponding to Pyrantel embonate 144 mg)

Praziquantel 50 mg

Each Veloxa XL chewable tablet contains:

Active substances

Febantel 525 mg

Pyrantel 175 mg (corresponding to Pyrantel embonate 504 mg)

Praziquantel 175 mg

For the full list of excipients, see below.

Pharmaceutical form

Chewable tablet.

Brownish, oval, divisible tablet. It can be divided into equal parts.

Clinical particulars

Target species

Dogs

Indications for use

Anthelmintic for treatment of mixed infections by the following roundworms and tapeworms in dogs and puppies:

Ascarids: Toxocara canis, Toxascaris leonina (adult and late immature forms)

Hookworms: Uncinaria stenocephala, Ancylostoma caninum (adults)

Whipworms: Trichuris vulpis (adults)

Tapeworms: Echinococcus spp., Taenia spp. and Dipylidium caninum (adult and immature forms).

Contra-indications

Do not use in animals with a known hypersensitivity to any of the active substances or the excipients. Please also see 'Use during pregnancy, lactation or lay' section and 'Interactions' section.

Special warnings for each target species

Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class.

Fleas serve as intermediate hosts for one common type of tapeworm - Dipylidium caninum. Tapeworm infestation is certain to reoccur unless control of intermediate hosts such as fleas, mice, etc. is undertaken.

Special precautions for use in animals

Veloxa is recommended for use in dogs less than 17.5 kg bodyweight. Veloxa XL is recommended for use in dogs over 17.5 kg bodyweight.

Tapeworm infestation is unlikely in pups less than 6 weeks of age. The tablets are flavoured. In order to avoid any accidental ingestion, store tablets out of reach of animals. To minimise the risk of re-infestation and new infestation, excreta should be collected and properly disposed of for 24 hours following treatment.

Special precautions to be taken by the person administering the medicinal product to animals

In the interests of good hygiene, persons administering the chewable tablet directly to a dog or by adding it to the dog's food, should wash their hands afterwards. In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.

Other precaution

Since it contains praziquantel, the product is effective against Echinococcus spp. which do not occur in all EU member states but are becoming more common in some. Echinococcosis represents a hazard for humans. As Echinococcosis is a notifiable disease to the World Organisation for Animal Health (OIE), specific guidelines on the treatment and follow-up, and on the safeguard of persons, need to be obtained from the relevant competent authority.

Adverse reactions

In very rare cases (less than 1 animal in 10,000 animals, including isolated reports) transient, mild gastrointestinal signs (e.g. vomiting) may occur.

Use during pregnancy, lactation or lay

Teratogenic effects attributed to high doses of febantel have been reported in sheep and rats. No studies have been performed in dogs during early pregnancy. Use of the product during pregnancy should be in accordance with a benefit/risk assessment by the responsible veterinarian. It is recommended that the product is not used in dogs during the first 4 weeks of pregnancy. Do not exceed the stated dose when treating pregnant bitches.

The chewable tablets may be used during lactation.

Interactions

Do not use simultaneously with piperazine as the anthelmintic effects of pyrantel and piperazine may be antagonised.

Concurrent use with other cholinergic compounds can lead to toxicity.

Plasma concentrations of praziquantel may be decreased by concomitant administration with drugs that increase the activity of cytochrome P-450 enzymes (e.g. dexamethasone, phenobarbital).

Amounts to be administered and administration route

For oral administration only.

Veloxa Dosage

1 chewable tablet per 10 kg bodyweight (15 mg febantel, 5 mg pyrantel (as embonate) and 5 mg praziquantel/kg bodyweight).

Weight (kg)

Number of chewable tablets
2.5 - 5 ½
> 5 - 10 1
> 10 - 15
> 15 - 20 2
> 20- 25
> 25 - 30 3
For dogs weighing more than 30 kg (i.e. >30 kg) the XL strength should be used. To ensure administration of a correct dose, body weight should be determined as accurately as possible.

Veloxa XL Dosage

1 chewable tablet per 35 kg bodyweight (15 mg febantel, 5 mg pyrantel (as embonate) and 5 mg praziquantel/kg body weight).

Weight (kg) Number of chewable tablets
17.5 ½
>17.5 - 35 1
>35 - 52.5
>52.5 - 70 2
Do not use for treatment of dogs weighing less than 17.5 kg (i.e. <17.5 kg). To ensure administration of a correct dose, body weight should be determined as accurately as possible.

Administration

The chewable tablets can be given directly to the dog or disguised in food. No starvation is needed before or after treatment. Due to a lipid-coating of praziquantel and added flavour, the chewable tablets are taken by most dogs voluntarily.

Duration of treatment

Not for use in dogs weighing less than 2 kg. A single dose shall be used. If there is a risk of re-infestation, the advice of a veterinarian should be sought regarding the need for and the frequency of repeat administration.

Overdose

In safety studies, a single dose of 5 times the recommended dose or greater gave rise to occasional vomiting.

Pharmacological particulars

Pharmacodynamic properties

In this fixed combination product pyrantel and febantel act against all relevant nematodes (ascarids, hookworms and whipworms) in dogs. In particular, the activity spectrum covers Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum and Trichuris vulpis. This combination shows synergistic activity in the case of hookworms and febantel is effective against T. vulpis. The spectrum of activity of praziquantel covers all important cestode species in dogs, in particular all Taenia spp, Dipylidium caninum, Echinococcus granulosus and Echinococcus multilocularis. Praziquantel acts against adult and immature forms of these parasites.

Praziquantel is very rapidly absorbed and distributed throughout the parasite. Both in vitro and in vivo studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolisation of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium.

Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis and thereby allow removal from the gastrointestinal system by peristalsis.

Within the mammalian system febantel undergoes ring closure forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerisation. Formation of microtubules is thereby prevented, resulting in disruption to structures vital to the normal functioning of the helminth. Glucose uptake, in particular, is affected, leading to depletion in cell ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2-3 days later.

Pharmacokinetic properties

After oral administration, praziquantel is almost completely absorbed from the intestinal tract. After absorption, the drug is widely distributed in the organism, metabolised into inactive forms in the liver and secreted in bile. It is excreted within 24 hours to more than 95% of the administered dosage.

The embonate salt of pyrantel has low aqueous solubility, an attribute that reduces absorption from the gut and allows the drug to reach and be effective against parasites in the large intestine. Following absorption, pyrantel embonate is quickly and almost completely metabolised into inactive components which are rapidly excreted in the urine.

Febantel is an inactive pro-drug which is absorbed and then metabolised relatively rapidly to a number of metabolites, including fenbendazole and oxfendazole, which have anthelmintic activity.

Following the single oral administration of this veterinary medicinal product the maximum plasma concentrations of praziquantel, pyrantel, fenbendazole and oxfendazole were found 327, 81, 128 and 165 ng/ml and were obtained after 2.2, 4.5, 5.2 and 6.3 hours.

Pharmaceutical particulars

Excipients

Cetyl palmitate, Starch (pregelatinised), Sodium starch glycolate (type A), Colloidal anhydrous silica, Magnesium stearate, Artificial beef flavour.

Major incompatibilities

Not applicable.

Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.

Shelf-life of half tablets: 2 days

Special precautions for storage

This medicinal product does not require any special storage conditions.

Keep the blister in the outer carton.Each time an unused half tablet is stored it should be returned to the open blister space and the blister inserted back into the outer carton.

Immediate packaging

PVC/Aluminium/Polyamide blister-forming laminate with aluminium lidding foil containing 2 or 8 (Veloxa strength only) chewable tablets.

Veloxa packs: 2, 4, 8, and 104 chewable tablets.

Veloxa XL packs: 2, 4, 8, 48 and 96 chewable tablets.

Not all pack sizes may be marketed.

Disposal

Any unused veterinary medicinal products or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Lavet Pharmaceuticals Ltd

Batthyány u. 6.

2143 Kistarcsa

Hungary

Marketing Authorisation Number

Veloxa Chewable Tablets for Dogs: Vm 32823/4010

Veloxa XL Chewable Tablets for Dogs: Vm 32823/4011

Significant changes

Legal category

Legal category:NFA-VPS

Delivery

Shipping charges mainland UK zone1

ValueWeightDelivery Charge
Over £49.00Any WeightFREE
Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

Returns

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

Frequently Asked Questions

Can i use on 18weeks 10kg puppy

Yes this would be suitable. Use one tablet per 10kg bodyweight

Ask Question

Ask a question about Veloxa Chewable Dog Worming Tablets


Reviews

5/5

Easy to use and great price

Reviewed by: Gemma Heagney

Reviewed on: 14 October 2019

Product Variant: VELOXA PK4

5/5

Does the job no problem getting the dogs to take it

Reviewed by: Phyllis Wright

Reviewed on: 06 August 2019

Product Variant: VELOXA PK4

5/5

I have always used this brand, very good

Reviewed by: Wendy Allchin

Reviewed on: 25 May 2018

Product Variant: VELOXA PK4

4/5

We've tried various worming treatments for our dog & this is the only one she's happy to take. Smothered in a little peanut butter of course.

Reviewed by: Tim Steele

Reviewed on: 09 February 2018

Product Variant: VELOXA PK4

5/5

Easy to use, good price arrived before expected

Reviewed on: 14 November 2017

Product Variant: VELOXA PK4

Show More Reviews (20) Show Fewer Reviews (20)

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