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Urilin Syrup

Item Number: URILIN

Urilin Syrup - Urilin Syrup

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  • 100ml

    £ 31.19

    Sorry, this product is not currently available to buy. This is likely because of a manufacturer delay. Call us on 01833 641112 for more information. We may also be able to suggest an alternative.
  • 45ml

    £ 14.69

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Description

Phenylpropanolamine is a sympathomimetic agent, which acts by direct stimulation of the smooth muscle of the urethral sphincter. It is indicated in the management of urinary incontinence associated with urethral sphincter incompetence in the bitch. The efficacy of phenylpropanolamine has only been demonstrated in ovariohysterectomised bitches.


Data Sheets

SUMMARY OF PRODUCT CHARACTERISTICS

1. NAME OF THE VETERINARY MEDICINAL PRODUCT Urilin 40 mg/ml syrup for dogs

2. QUALITATIVE AND QUANTITATIVE COMPOSITION 1 ml contains: Active substance: Phenylpropanolamine 40.29 mg (equivalent to 50.0 mg phenylpropanolamine hydrochloride) Excipients: Sodium methyl parahydroxybenzoate (E219) 1.5 mg Sodium propyl parahydroxybenzoate 0.15 mg For the full list of excipients, see section 6.1.

3. PHARMACEUTICAL FORM Syrup. Clear viscous solution.

4. CLINICAL PARTICULARS

4.1 Target species Dogs (bitches).

4.2 Indications for use, specifying the target species For the treatment of urinary incontinence associated with acquired urethral sphincter incompetence in the bitch only. The efficacy of phenylpropanolamine has only been demonstrated in ovariohysterectomised bitches.

4.3 Contraindications Please see section 4.7. Do not use in animals treated with non-selective monoamine oxidase inhibitors. Do not use in cases of known hypersensitivity to the active substance or to any of the excipients.

4.4 Special warnings for each target species It is not appropriate to use the product for the behavioural cause of inappropriate urination. Revised: August 2015 AN: 00629/2015 Page 2 of 5

4.5 Special precautions for use Special precautions for use in animals Because phenylpropanolamine is a sympathomimetic agent, it may affect the cardiovascular system, especially blood pressure and heart rate, and therefore should be used with caution in animals with cardiovascular diseases. Care should be exercised in treating animals with severe renal or hepatic insufficiency, diabetes mellitus, hyperadrenocorticism, glaucoma or other metabolic disorders. In bitches less than 1 year old the possibility of anatomical disorders contributing to incontinence should be considered prior to treatment. Special precautions for the person administering the veterinary medicinal product to animals • People with known hypersensitivity to phenylpropanolamine should avoid contact with the veterinary medicinal product. • Phenylpropanolamine hydrochloride is toxic when overdoses are ingested. Adverse effects may include dizziness, headache, nausea, insomnia or restlessness, and increased blood pressure. High overdose may be fatal, especially in children. • To avoid accidental ingestion the product must be used and kept out of the sight and reach of children. • Always replace the cap firmly after use to ensure that the child resistant closure operates correctly. • In the event of accidental ingestion, seek immediate medical attention showing the doctor the package leaflet. • Contact with eyes and skin should be avoided. • In the event of accidental skin contact, wash the contaminated area with soap and water. Wash hands after use of the product. • Redness and irritation may develop after eye or skin contact with the product. • In the event of accidental eye contact, rinse the eye with clean water for about 15 minutes and seek medical advice.

4.6 Adverse reactions (frequency and seriousness) In some dogs, loose stools, liquid diarrhoea, a decrease in appetite, arrhythmia and collapse have been reported following treatment with phenylpropanolamine. Occasional nausea and vomiting have also been reported. Treatment was continued depending on the severity of the undesirable effect observed. As phenylpropanolamine is a sympathomimetic agent it is possible to produce a wide range of effects most of which mimic the results of excess stimulation of the sympathetic nervous system (e.g. effects on the heart rate and blood pressure). Dizziness and restlessness were also occasionally reported. Hypersensitivity may occur in very rare cases.

4.7 Use during pregnancy, lactation or lay Do not use in pregnant or lactating bitches. Revised: August 2015 AN: 00629/2015 Page 3 of 5

4.8 Interaction with other medicinal products and other forms of interaction Care should be exercised in administering the product with other sympathomimetic drugs, anticholinergic drugs, tricyclic antidepressants or specific type B monoamine oxidase.

4.9 Amount to be administered and administration route For oral administration. 0.8 mg/kg body weight phenylpropanolamine (equivalent to 1 mg/kg phenylpropanolamine HCl) three times daily in the feed, corresponding to 0.1 ml Urilin syrup/5 kg body weight three times daily. 1 drop for every 2.34 kg body weight three times daily in feed.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary In healthy dogs, no side effects were observed at up to 5 times the recommended dose. However an overdose could produce signs of excessive stimulation of the sympathetic nervous system. Treatment should be symptomatic. Alpha-adrenergic blockers may be appropriate in the case of severe overdose. However, no specific recommendation on drugs or dosages can be given.

4.11 Withdrawal period(s) Not applicable.

5. PHARMACOLOGICAL PROPERTIES Pharmacotherapeutic group: Phenylpropanolamine hydrochloride is a sympathomimetic agent. ATCvet Code: QG04BX91

5.1 Pharmacodynamic properties Sympathetically innervated smooth muscles play a role in urethral closure, and both the α and β receptors are present. The α receptors play a role in urethral closure while β receptors innervate relaxation. The smooth muscle extends to the mid-urethra in females. The clinical effect of phenylpropanolamine is based on its stimulation effects on α-adrenergic receptors. This causes an increase in, and stabilisation of, the closure pressure in the urethra, which is innervated mainly by the adrenergic nerves. Phenylpropanolamine is a racemic mixture of D and L enantiomers.

5.2 Pharmacokinetic particulars In the dog, the mean half-life of phenylpropanolamine is approximately 3 hours with maximal plasma concentrations being found after approximately 4 hours. No accumulation of phenylpropanolamine has been observed after a dose of 1 mg/kg 3 times daily over 15 days. Revised: August 2015 AN: 00629/2015 Page 4 of 5

6. PHARMACEUTICAL PARTICULARS

6.1 List of excipients Sodium methyl parahydroxybenzoate (E219) Sodium propyl parahydroxybenzoate Maltitol liquid Saccharin sodium Citric acid monohydrate (E330) Purified water

6.2 Incompatibilities None known.

6.3 Shelf life Shelf life of the veterinary medicinal product as packaged for sale: 3 years. Shelf life after first opening the immediate packaging: 3 months.

6.4 Special precautions for storage Do not store above 25°C. Keep the container in the outer carton.

6.5 Nature and composition of immediate packaging 50 ml or 100 ml amber type III glass bottles containing 45 ml or 100 ml of syrup, with a low density polyethylene dropper and a polypropylene child resistant screw cap. Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

7. MARKETING AUTHORISATION HOLDER Dechra Limited Snaygill Industrial Estate Keighley Road Skipton North Yorkshire BD23 2RW

8. MARKETING AUTHORISATION NUMBER Vm 10434/4003 Revised: August 2015 AN: 00629/2015 Page 5 of 5

9. DATE OF FIRST AUTHORISATION 28 January 2005

10. DATE OF REVISION OF THE TEXT August 2015 Approved: 04 September 2015

Delivery

Shipping charges mainland UK zone1

ValueWeightDelivery Charge
Over £49.00Any WeightFREE
Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

Returns

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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Reviews

5/5

It works very well. Yyyyyyyy

Reviewed by: Steve McLeish

Reviewed on: 18 January 2019

Product Variant: URILIN 100ML

1/5

Never received the goods tried emailing hyperdrug and the kept saying that they did not recognise the email address

Reviewed by: S Parsons

Reviewed on: 09 February 2018

Product Variant: URILIN 100ML

5/5

Good product works really well for my twelve year old Giant Schnauzer

Reviewed by: Dawn

Reviewed on: 17 February 2016

Product Variant: URILIN 100ML

5/5

As Above

Reviewed on: 09 September 2014

Product Variant: URILIN 45ML

5/5

As Above

Reviewed on: 11 June 2014

Product Variant: URILIN 45ML

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