Item Number: URILIN
Presentation A clear liquid containing Phenylpropanolamine Hydrochloride Ph Eur 40 mg/ml Uses Phenylpropanolamine is a sympathomimetic agent, which acts by direct stimulation of the smooth muscle of the urethral sphincter. It is indicated in the management of urinary incontinence associated with urethral sphincter incompetence in the bitch. The efficacy of phenylpropanolamine has only been demonstrated in ovariohysterectomised bitches. Dosage and administration The recommended dose of phenylpropanolamine is 1 mg/kg bodyweight three times daily. 1 mg/kg bodyweight 3 times daily in the feed, corresponding to 0.1 ml Urilin® Syrup/ 5 kg bodyweight three times daily. One drop (2.34 mg) for every 2.34 kg bodyweight three times daily in feed. Do not shake the bottle, simply invert it over the food and count the required number of drops. Contra-indications, warnings, etc Aggressiveness and restlessness have been noted in some dogs following treatment. Not to be used in pregnant or lactating bitches. It is not appropriate to use the product for the behavioural cause of inappropriate urination. In some dogs, loose stools, liquid diarrhoea, a decrease in appetite, arrhythmia and collapse have been reported following treatment with phenylpropanolamine. Occasional nausea and vomiting have also been reported. As phenylpropanolamine is a sympathomimetic it is possible to produce a wide range of effects most of which mimic the results of excess stimulation of the sympathetic nervous system (e.g. effects on the heart rate and blood pressure). Because phenylpropanolamine is a sympathomimetic drug, it may affect the cardiovascular system, especially blood pressure and heart rate and therefore should be used with caution in animals with cardiovascular diseases. Care should be exercised in treating animals with severe renal or hepatic insufficiency, diabetes mellitus, hyperadrenocorticism, glaucoma or other metabolic disorders. In bitches less than 1 year old the possibility of anatomical disorders contributing to incontinence should be considered prior to treatment. Care should be exercised in administering the product with other sympathomimetic drugs, anticholinergic drugs, tricyclic antidepressants or specific type B monoamine oxidase. The product should not be administered to patients treated with non-selective monoamine oxidase inhibitors. Signs of overdose could produce signs of excessive stimulation of the sympathetic nervous system. Treatment should be symptomatic. Lethargy and inappetance have been reported in a dog following an overdose (2.5 mg/kg 3 times daily). Sympathomimetics may produce a wide range of effects, most of which mimic the results of excessive stimulation of the sympathetic nervous system. Headaches, hypotension and dizziness have been reported in man. In the event of accidental skin contact, wash the contaminated area with soap and water. Wash hands after use of the product. In the event of accidental eye contact, rinse the eye with clean water for about 15 minutes and seek medical advice. To avoid accidental ingestion, the product must be used and kept out of the reach of children. Always replace the cap securely after use. In the event of accidental ingestion, seek immediate medical attention showing the doctor the package insert. For animal treatment only. Keep out of the reach of children Pharmaceutical precautions Do not store above 25°C. Do not refrigerate. Legal category POM-V (previously POM). Packaging Quantities 30 ml, 45 ml and 100 ml supplied in 30 ml, 50 ml and 100 ml glass bottles. Further information Urinary incontinence in the dog may be due to several underlying mechanisms. Urilin® is most effective in the control of urinary incontinence due to urethral sphincter incompetence in the bitch, particularly that associated with ovariohysterectomy. It is not effective in all cases and may be of limited effectiveness in other forms of urinary incontinence. Dispose of unused packaging in the household refuse. Unused product should be returned to the veterinary surgeon. Marketing authorisation number Vm 10434/4003.