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Relaquine Gel 10ml

Item Number: RELAQUINE

Relaquine Gel 10ml
  • 10ml

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    £ 22.49

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Description

Relaquine Gel 10ml. For sedation of horses.


Data Sheets

Relaquine® 35 mg/ml Oral Gel for Horses Species:Horses and other equidae

Therapeutic indication:Pharmaceuticals: Neurological preparations: Tranquilisers

Active ingredient:Acepromazine Maleate

Product:Relaquine® 35 mg/ml Oral Gel for Horses

Product index:Relaquine 35 mg/ml Oral Gel for Horses

Withdrawal notes:Not authorised for use in horses intended for human consumption.

Qualitative and quantitative composition

Each ml contains: Active substance:

Acepromazine 35.00 mg (as acepromazine maleate 47.50 mg)

Excipients:

Methyl parahydroxybenzoate (E218) 0.65 mg

Propyl parahydroxybenzoate 0.35 mg

Pharmaceutical form

Oral gel. Clear yellow gel for oral administration.

Clinical particulars

Target species

Horse.

Indications for use

For sedation of horses.

Contraindications

Do not use in cases of post-traumatic shock or hypovolaemia.

Do not use in animals in a state of severe emotional excitation.

Do not use in animals with epilepsy.

Do not use in pregnant or lactating mares.

Do not use in animals with heart failure.

Do not use in animals with haematological disorders/coagulopathies.

Do not use in animals suffering from hypothermia.

Do not use in the case of known hypersensitivity to the active substance or any of the excipients of the product.

Do not use in neonates.

Special warnings for each target species

Sedation lasts for approximately six hours, although the actual time and depth of sedation are very dependent on the status of the individual animal.

Increasing the dosage above that recommended results in prolonged action and side effects but no greater sedation.

Special precautions for use in animals

In stallions, the lowest dose range is indicated to minimise prolapse of the penis.

The product should be used with caution and with reduced dosage in the case of cardiac or hepatic disease or in debilitated, hypovolemic or anaemic animals.

Acepromazine has negligible analgesic effects. Painful activities should be avoided when handling tranquilised animals.

Tranquilised horses should be kept in a calm place and sensorial stimuli should be avoided as far as possible.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Wash hands and exposed skin thoroughly after use. Persons with sensitive skin or in continuous contact with the product are advised to wear impermeable gloves.

Avoid contact with eyes. If accidental eye contact occurs, flush gently with running water for 15 minutes and seek medical advice if any irritation persists.

In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician but, DO NOT DRIVE as sedation can occur.

Adverse reactions

The frequency of adverse reactions is defined using the following convention:

- very common (more than 1 in 10 animals displaying adverse reaction(s) during the course of one treatment)

- common ( more than 1 but less than 10 animals in 100 animals)

- uncommon (more than 1 but less than 10 animals in 1,000 animals)

- rare (more than 1 but less than 10 animals in 10,000 animals)

- very rare (less than 1 animal in 10,000 animals, including isolated reports).

Since acepromazine decreases sympathetic nervous system tone, a transient drop in blood pressure may occur after administration.

Inhibition of temperature regulation.

The following reversible changes are possible in the haemogram:

- transient decrease in erythrocyte count and haemoglobin concentration;

- transient decrease in thrombocyte and leukocyte counts.

Because it increases prolactin secretion, the administration of acepromazine may lead to disturbances in fertility.

Penile prolapse may occur due to the relaxation of the retractor penis muscles. Retraction of the penis should be visible within two to three hours. If this does not take place, it is advised to contact a veterinary surgeon. Lack of retraction is of particular concern in breeding stallions. Acepromazine has caused paraphimosis sometimes in sequel to priaprism.

In rare cases paradoxical excitation reactions can develop.

Contradictory clinical signs of aggressiveness and generalised CNS stimulation may occur.

Prolapse of the nictitating membrane has also been cited as a possible adverse effect in horses.

Use during pregnancy and lactation

Acepromazine should not be used in pregnant or lactating mares.

Acepromazine has the potential to induce hypotension in newborns when administered as a premedication for caesarean section in the mare.

Please see also Adverse reactions relating to disturbances in fertility.

Interactions

Acepromazine potentiates the action of centrally depressant drugs.

Simultaneous administration, or administration to horses recently treated with organophosphates should be avoided since these molecules enhance the toxic effects of acepromazine. Since acepromazine decreases sympathetic nervous system tone, simultaneous treatment with blood pressure lowering products should not take place.

Antacids may cause a decrease in the gastrointestinal absorption of acepromazine after oral administration.

Opiates may enhance the hypotensive effects of acepromazine.

Amounts to be administered and administration route

For oral administration.

The product is contained within a 10 ml or 15 ml polyethylene syringe. The plunger has a locking ring which should be adjusted to provide the volume required in accordance with the dosage guidelines. 1.0 ml intervals are printed on the syringe plunger, but it is also possible to dose at 0.5 ml intervals.

Before first use of the syringe, turn the locking ring clockwise until aligned with the 0.0 ml mark (side of the ring facing the barrel). Turn the locking ring anticlockwise will move the ring backwards. Turn the locking ring backwards until the left side of the locking ring lines up with the volume of the oral gel to be administered.

Place the syringe in the animal's mouth and expel the required dose into the cheek pouch. The gel may also be mixed with food.

Glass bottle

The product is filled into 10, 15, 20, 30 and 50 ml glass bottles with CRC closure and supplied with a 5 ml syringe with a dose graduation allowing accurate dosing of 0.1 or 0.2 ml. Withdraw the appropriate dose from the bottle using the supplied syringe. The syringe is brought into the animal's mouth and the appropriate dose is expelled into the animal's cheek.

The gel may also be mixed with food.

Amount(s) to be administered:

Moderate sedation: 0.15 mg acepromazine per kg body weight.

Dosage guidelines:

Body weight (kg)

200 300 400 450 500 600
Dose (ml) 1.0 1.5 1.5 2.0 2.5 2.5
The above dosage information is provided as a guideline. The dose may be varied to administer between 0.5 and 1.5 times the above recommendation depending on the level of sedation required, i.e. for mild sedation, administer half the recommended dose and for deeper sedation, administer 1½ times the recommended dose.

Overdose

Overdosage results in an earlier onset of the sedative symptoms and in a prolonged effect.

Toxic effects are ataxia, hypotension, hypothermia and central nervous system (extrapyramidal) effects.

Noradrenaline, but not adrenaline, can be used to counteract the cardiovascular effects.

Withdrawal period

Not authorised for use in horses intended for human consumption.

Pharmacological particulars

Pharmacotherapeutic group: Nervous system.

ATCvet code: QN05AA04

Pharmacodynamic properties

Acepromazine is a phenothiazine derivative. This group of molecules belongs to the neuroleptics: they depress the central nervous system and exert associated effects on the autonomic system. These effects are due to their interference with different neurotransmitter receptors (dopaminergic, adrenergic) and to their interference with hypothalamic performance. The sedative activity starts within 15-30 minutes of treatment and lasts for 6-7 hours.

The desired effects observed after treatment with acepromazine include a general tranquilising effect, anti-emetic effect and a slight anti-histaminic effect. There is no analgesic action. The neuroleptic effects are variable between individual animals.

Pharmacokinetic properties

Acepromazine is partly absorbed from the gastrointestinal tract. Plasma protein binding is high and it is extensively distributed throughout the body tissues. Plasma levels are usually low. Acepromazine is highly metabolised, with the urine as the main route of excretion.

Pharmaceutical particulars

Incompatibilities

In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 2 years.

Shelf life after first opening the immediate packaging: 90 days.

Special precautions for storage

Do not store above 25°C. Protect from frost. Protect from light. After use, replace cap on syringe. Keep the broached syringe in the original carton and store in a dry place.

Immediate packaging

Prefilled syringes:

Container: White, high-density polyethylene syringe barrel and a white, low-density polyethylene syringe plunger closed with a white, high-density polyethylene, push-fit cap.

Or

White, linear low-density polyethylene syringe closed with a linear low-density polyethylene, push-fit cap.

Fill volume: 10 ml / 15 ml

Dosing device: The product is presented in an oral dosing syringe which is graduated at 1 ml intervals.

Glass bottles

Container: Amber Type III glass bottles of 10, 15, 20, 30 and 50 ml, fitted with syringe adaptors and HDPE/LDPE CRC closures containing 9 ml, 14 ml, 18 ml, 28 ml and 48 ml product, respectively.

Dosing device: The product is presented with an oral dosing syringe of 5 ml which is graduated at 0.1 or 0.2 ml intervals.

Not all pack sizes may be marketed.

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Floris Animal Health Limited, Bath House 6-8, Bath Street, Bristol, BS1 6HL, United Kingdom.

Marketing Authorisation Number

Vm 52764/4001

Significant changes

Date of the first authorisation or date of renewal

10 March 2011

Date of revision of the text

July 2021

Any other information

For animal treatment only. To be supplied only on veterinary prescription. Keep out of the sight and reach of children.

Legal category

Legal category:POM-V

GTIN

GTIN description:Relaquine 35 mg/ml Oral Gel for Horses 10 ml:

GTIN:08714225153626

Delivery

Shipping charges mainland UK zone1

ValueWeightDelivery Charge
Over £49.00Any WeightFREE
Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

Returns

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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