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Previcox Chewable Tablets

Item Number: PREVICOX

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Description

Presentation

Tan-brown, round, convex, engraved, scored chewable tablets, each containing 57mg or 227 mg firocoxib.

Uses

Firocoxib is a non-steroidal anti-inflammatory drug (NSAID) belonging to the Coxib group, which acts by selective inhibition of cyclooxygenase-2 (COX-2) – mediated prostaglandin synthesis. PREVICOX tablets are for the relief of pain and inflammation associated with osteoarthritis in dogs and for the relief of post-operative pain and inflammation associated with soft-tissue and orthopaedic surgery in dogs.

Dosage and administration

Osteoarthritis:

The recommended oral dose is 5 mg per kg bodyweight once daily, as shown in the table below. Tablets can be administered with or without food. Duration of treatment will be dependent on the response observed. As field studies were limited to 90 days, this should be borne in mind when considering longer-term treatment, with regular monitoring carried out by the veterinarian.

Relief of post-operative pain:

The recommended oral dose is 5 mg per kg bodyweight once daily, as shown in the table below, for up to 3 days as needed, starting approximately 2 hours prior to surgery.

Following orthopaedic surgery and depending on the response observed, treatment using the same daily dosing schedule may be continued after the first 3 days, upon judgement of the attending veterinarian.

Body weight (kg)

Number of chewable tablets

mg/kg range

57mg

227mg

3 - 5.5

0.5

5.2 - 9.5

5.6 - 10

1

5.7 - 10.2

10.1 - 15

1.5

5.7 - 8.5

15.1 - 22

0.5

5.2 - 7.5

22.1 - 45

1

5.0 - 10.3

45.1 - 68

1.5

5.0 - 7.5

68.1 - 90

2

5.0 - 6.7

Contra-indications, warnings, etc

For animal treatment only. Do not exceed the recommended dose. Do not use in pregnant or lactating bitches.

Do not use in animals less than 10 weeks of age or less than 3 kg body weight. Do not use in animals suffering from gastrointestinal bleeding, blood dyscrasia or haemorrhagic disorders. Where there is a risk of gastrointestinal bleeding, or if the animal previously displayed intolerance to NSAIDs, use this product under strict veterinary monitoring.

Vomiting and diarrhoea have occasionally been reported. These reactions are generally of a transitory nature and are reversible when the treatment is stopped. Rarely, nervous system disorders have been reported in treated dogs.

Do not use concomitantly with corticosteroids or other NSAIDs. Use in very young animals, or animals with suspected or confirmed impairment of renal, cardiac or hepatic function may involve additional risk. If such use cannot be avoided, those dogs require careful veterinary monitoring.

Avoid use in any dehydrated, hypovolaemic or hypotensive animals, as there is a potential risk of increased renal toxicity. Concurrent administration of potentially nephrotoxic drugs should be avoided.

Renal and/or hepatic disorders have been reported in very rare cases in dogs administered the recommended treatment dose. It is possible that a proportion of such cases had sub-clinical renal or hepatic disease prior to the commencement of therapy. Therefore, appropriate laboratory testing to establish baseline renal or hepatic biochemistry parameters is recommended prior to and periodically during administration.

The treatment should be discontinued and the advice of a veterinarian should be sought if any of these signs are observed: repeated diarrhoea, vomiting, faecal occult blood, sudden weight loss, anorexia, lethargy, degradation of renal or hepatic biochemistry parameters. As with other NSAIDs, serious adverse effects can occur and, in very rare cases, may be fatal.

Laboratory studies in rabbits have shown evidence of maternotoxic and foetotoxic effects at dose rates approximating the recommended treatment dose for the dog. Pre-treatment with other anti-inflammatory substances may result in additional or increased adverse effects and accordingly a treatment-free period with such drugs should be observed for at least 24 hours before the commencement of treatment with PREVICOX. The treatment-free period, however, should take into account the pharmacokinetic properties of the products used previously.

PREVICOX must not be administered in conjunction with other NSAIDs or glucocorticosteroids. Gastrointestinal tract ulceration may be exacerbated by corticosteroids in animals given non-steroidal anti-inflammatory drugs.

Concomitant treatment with molecules displaying action on renal flow, e.g. diuretics or Angiotensin Converting Enzyme (ACE) inhibitors, should be subject to clinical monitoring. Concurrent administration of potentially nephrotoxic drugs should be avoided, as there might be an increased risk of renal toxicity. As anaesthetic drugs may affect renal perfusion, the use of parenteral fluid therapy during surgery should be considered to decrease potential renal complications when using NSAIDs peri-operatively.

Concurrent use of other active substances that have a high degree of protein binding may compete with firocoxib for binding and thus lead to toxic effects.

In the event of accidental ingestion, seek medical advice immediately and show the package leaflet or label to the physician. Wash hands after use of the product.

Return halved tablets to the blister and keep out of the reach of children.

Disposal advice

Any unused product or waste material should be disposed of in accordance with local requirements.

Pharmaceutical precautions

Do not store above 300C. Store in the original package. Halved tablets may be kept for up to 7 days in the original container.

Legal category

POM-V

Packaging Quantities

PREVICOX tablets are supplied in carton boxes containing blisters (transparent PVC /aluminium foil and paper backing).

The chewable tablets are available in the following pack sizes:

57mg: 1 carton box containing three blisters of 10 tablets

227 mg: 1 carton box containing three blisters of 10 tablets

Further information

Firocoxib is approximately 96% bound to plasma proteins. Following multiple oral administrations, the steady state is reached by the third daily dose.

Firocoxib is metabolised predominantly by dealkylation and glucuronidation in the liver. Elimination is principally in the bile and gastrointestinal tract.

PREVICOX chewable tablets are scored to facilitate accurate dosing and contain caramel and smoke flavours to facilitate administration to dogs.

Mode of action: Firocoxib is a non-steroidal anti-inflammatory drug (NSAID) that acts by selective inhibition of cyclooxygenase-2 (COX-2) – mediated prostaglandin synthesis. COX-2 is the isoform of the enzyme that has been postulated to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever. In in-vitro canine whole blood assays, firocoxib exhibited approximately 380-fold selectivity for COX-2 over COX-1.


Data Sheets

PREVICOX 227MG1TAB: Data Sheet

PREVICOX 57MG1TAB: Data Sheet

Delivery

Shipping charges mainland UK zone1

ValueWeightDelivery Charge
Over £49.00Any WeightFREE
Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

Returns

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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Reviews

5/5

Very good they work very effectively on my horse who suffers from stiff joints. They are easy to administer in a piece of bread/apple.

Reviewed on: 04 March 2020

Product Variant: PREVICOX 57MG1TAB

5/5

Making a difference to our old lady who still likes to chase a ball

Reviewed on: 26 February 2020

Product Variant: PREVICOX 227MG1TAB

5/5

Speedy and efficient service

Reviewed by: Richard Goodwin

Reviewed on: 26 February 2020

Product Variant: PREVICOX 227MG1TAB

5/5

Previcox seems to work very well on our dog

Reviewed on: 21 October 2019

Product Variant: PREVICOX 227MG1TAB

5/5

un vrai service que de pouvoir acheter à l'unité

Reviewed on: 14 October 2019

Product Variant: PREVICOX 57MG1TAB

Show More Reviews (50) Show Fewer Reviews (50)

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