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Pharmasin 100% W/W Granules for use in drinking water

Item Number: PHARMASIN

Pharmasin 100% W/W Granules for use in drinking water
  • 110g

    Estimated dispatch on Monday

    £ 20.19

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Description

Pharmasin 100% W/W Granules for use in drinking water.

Target species:
Calves, pigs, chickens, turkeys

Indications for use
Calves: Treatment and prevention of pneumonia caused by Mycoplasma spp when the disease has been established in the herd.
Pigs: Treatment and prevention of enzootic pneumonia caused by Mycoplasmahyopneumoniae and Mycoplasma hyorhinis when the disease has been established in the herd.
Treatment and prevention of Porcine Intestinal Adenomatosis (Ileitis) associated withLawsonia intracellularis when the disease has been established in the herd.
Chickens: Treatment and prevention of chronic respiratory diseases (CRD) caused by Mycoplasma gallisepticum and Mycoplasma synoviae when the disease has been established in the flock.
Treatment and prevention of necrotic enteritis caused by Clostridium perfringens when the disease has been established in the flock.
Turkeys: Treatment and prevention of infectious sinusitis caused by Mycoplasma gallisepticum. when the disease has been established in the flock.

Contra-indications
Do not use in animals with known hypersensitivity to tylosin or other macrolides.
Do not use in cases of known resistance to tylosin or cross-resistance to other macrolides (MLS-resistance).
Do not use in animals vaccinated with tylosin-sensitive vaccines either at the same time or within 1 week previously.
Do not use in animals with hepatic disorders.
Do not use in horses.

Special warnings for each target species
Due to likely variability (time, geographical) in susceptibility of bacteria to tylosin, bacteriological sampling and susceptibility testing are recommended.
Under-dosing and/or treating for an insufficient length of time are considered to promote the development of resistance in bacteria and should be avoided.

Special precautions for use
Animals with acute infections may have a reduced water and feed consumption and should be treated with a suitable injectable veterinary medicinal product first.
Do not leave or dispose of water containing tylosin tartrate where it may be accessible to either animals not under treatment or wildlife.

Special precautions for the person administering the veterinary medicinal product to animals.
Tylosin may induce irritation. Macrolides, such as tylosin, may also cause hypersensitivity (allergy) following injection, inhalation, ingestion or contact with skin or eye.
Hypersensitivity to tylosin may lead to cross reactions to other macrolides and vice versa.
Allergic reactions to these substances may occasionally be serious and therefore direct contact should be avoided.
To avoid exposure during preparation of the medicated drinking water, wear overalls, safety glasses, impervious gloves and wear either a disposable half mask respirator conforming to European Standard EN149 or a non-disposable respirator to European Standard EN140 with a filter to EN143.

Adverse reations
In pigs, adverse reactions have been observed, including diarrhea, pruritus, erythema of the skin, swelling of the vulva, rectal edema and prolapse. These reversible signs appeared 48-72 hours after start of treatment.

Use during pregnancy, lactation or lay
Laboratory studies in mice and rats have not produced any evidence of teratogenic, foetotoxic or maternotoxic effects. No studies have been conducted in the target species. Use only according to the benefit/risk assessment by the responsible veterinarian.

Interactions
Antagonism with substances of the lincosamide group.

Amounts to be administered and administration route
Oral administration through the drinking water.
In calves the product can also be administered through milk or milk replacer.
1.1 gram of the veterinary medicinal product corresponds to 1 gram of tylosin. The dosages are as follows:

Calves:
10 – 20 mg tylosin per kg BW (corresponding to 11 – 22 mg of the veterinary medicinal product per kg BW), twice daily (corresponding to a daily dose of 20 – 40 mg tylosin per kg BW), for 7 - 14 days.

Turkeys:
75 – 100 mg tylosin per kg BW per day (corresponding to 82.5 – 110 mg of the veterinary medicinal product per kg BW) for 3 – 5 days.

Chickens:
For the treatment of chronic respiratory disease:
75 – 100 mg tylosin per kg BW per day (corresponding to 82.5 – 110 mg of the veterinary medicinal product per kg BW) for 3 – 5 days.
For the treatment of necrotic enteritis:
20 mg tylosin per kg BW per day (corresponding to 22 mg of the veterinary medicinal product) for 3 days.

Pigs:
For the treatment of enzootic pneumonia:
20 mg tylosin per kg BW per day (corresponding to 22 mg of the veterinary medicinal product per kg BW) for 10 days.
For the treatment of ileitis or PIA:
5 – 10 mg tylosin per kg BW per day (corresponding to 5.5 - 11 mg of the veterinary medicinal product per kg BW) for 7 days.
For the preparation of the medicated water/milk/milk-replacer the body weight of the animals
to be treated and their actual daily water/milk/milk-replacer consumption should be taken into due account. Consumption may vary depending on factors like age, state of health, breed, husbandry system. To provide the required amount of active substance in mg per litre drinking water/milk/milk-replacer the following calculation should be made:
h-648
Sufficient access to the system of water supply should be available for the animals to be treated to ensure adequate water consumption. No other source of drinking water should be available during the medication period.
Should there be no clear response to treatment within 3 days the treatment approach should be reconsidered. After the end of the medication period the water supply system should be cleaned appropriately to avoid intake of sub-therapeutic amounts of the active substance which might support development of resistance.
Medicated water, milk or milk replacer should be replaced every 24 hours.
If individual animals show signs of a serious infection such as a reduced water or feed intake, then they should be treated individually, such as by injection.

Overdose
There is no evidence of tylosin toxicity in rats, at dose rates of up to 1000 mg/kg by the oral route.
There is no evidence of tylosin toxicity in chickens, turkeys, pigs or calves when administered orally at up to three times the recommended dose.

Withdrawal periods
Calves (meat and offal): 12 days
Pigs (meat and offal): 1 day
Turkeys (meat and offal): 2 days
Turkey (eggs): Zero days
Chickens (meat and offal): 1 day
Chicken (eggs): Zero days

Pharmacological particulars

Pharmacodynamic properties
Tylosin is a macrolide antibiotic produced by a strain of Streptomyces fradiae. It exerts its antimicrobial effect by inhibiting protein synthesis of susceptible micro-organisms.
The tylosin spectrum of activity includes amongst others Gram-positive bacteria, some Gram–negative strains such as Pasteurella, and Mycoplasma spp.

Pharmacokinetic properties
In most species peak plasma concentrations have been attained 1 to 2 hours after administration of tylosin. Compared to plasma levels clearly higher tissue concentrations have been observed. Tylosin was extensively metabolised.
Most of the residues are excreted in faeces predominantly consisting of tylosin (factor A), relomycin (factor D) and dihydrodesmycosin

Pharmaceutical particulars

Excipients
None.

Major incompatibilities
In the absence of compatibility studies , this veterinary medicinal product must not be mixed with other veterinary medicinal products.

Shelf life
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years
Shelf-life after dilution or reconstitution according to directions:
medicated water: 24 hours
medicated milk or milk replacer: 24 hours
Shelf-life after first opening the immediate packaging: 3 months

Special precautions for storage
Store in the original container in order to protect from light. Store below 30°C.

Immediate packaging
1.1 kg resealable block bottom zipped sachet made of polyethylene /aluminium/polyethylene terephthalate laminate.
110 g high density polyethylene pot with polypropylene cap

Disposal
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.


Data Sheets

PHARMASIN 110G: Data Sheet

Delivery

Shipping charges mainland UK zone1

ValueWeightDelivery Charge
Over £49.00Any WeightFREE
Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

Returns

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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