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Ovuplant 2.1mg Implantation Tablets for Horses (Mares) (Pack 5)

Item Number: OVUPLANT

Ovuplant 2.1mg Implantation Tablets for Horses (Mares) (Pack 5)
  • Pack of 5

    £ 274.75

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Ovuplant 2.1mg Implantation Tablets for Horses (Mares) (Pack of 5). Target species: Horses (non-pregnant mares).

Indications for use:
In mares: Zootechnical treatment for the induction of ovulation within 48 hours, during oestrus in normally cycling mares (in sexual season), with an ovarian follicle greater than 30 mm diameter.

Special warnings for each target species:
Mares should be implanted with the veterinary medicinal product when a developing ovarian follicle greater than 30 mm in diameter has been detected by rectal palpation and/or ultrasonography. In larger breeds, it may be necessary to wait until the dominant follicle has progressed to 35 mm in diameter before administration of the veterinary medicinal product.

Treated mares should be bred or inseminated within the next 48 hours. The mare should be monitored to ensure that ovulation has occurred and that further breedings are not required. If ovulation does not occur within 48 hours of implantation, continue breeding according to routine management procedures.

It has been noted that follicles were significantly smaller before ovulation for deslorelin treated mares compared with placebo mares. However, treatment had no effect on the percentage of mares pregnant at days 18 or 50.

For all trials that evaluated conception and pregnancy rate, there were no differences between deslorelin-treated and non-treated mares at the end of the study.

Efficacy has not been established for mares in vernal (spring) transition phase.

Special precautions for use in animals:
Do not use if the foil pouch is broken.

Only one implant should be implanted per mare during a given oestrus.

The veterinary medicinal product has not been tested in mares less than three (3) years of age.

Use only in mares fit for reproduction.

Special precautions to be taken by the person administering the veterinary medicinal product to animals:
Pregnant women should not administer the veterinary medicinal product as GnRH analogues have been shown to be foetotoxic in laboratory animals.

When administering the veterinary medicinal product, take care to avoid accidental self-injection by ensuring that animals are suitably restrained and the application needle is shielded until the moment of implantation.

In the case of accidental self-injection, seek medical assistance immediately, with a view to having the implant removed, as GnRH analogues may have adverse effects on the male and female reproductive systems.

Although skin contact with the veterinary medicinal product is unlikely, should this occur, wash the exposed area immediately with soap and water, as GnRH analogues may be absorbed through the skin.

Adverse reactions:
Localised swelling and mild fibrosis at the site of implantation has been observed in some mares, accompanied by a slight increase in sensitivity to touch and an elevated skin temperature. These effects are transient and usually resolve without treatment within 2 to 5 days.

Some mares implanted with the veterinary medicinal product (deslorelin) may experience an increased dioestrous period following use.

Use during pregnancy and lactation:
Do not use during pregnancy. GnRH analogues have been shown to be foetotoxic in laboratory animals when administered during pregnancy.

Amounts to be administered and administration route:
One implant should be administered by subcutaneous implantation in the lateral neck region midway between the head and shoulder.

Prepare the implantation site by thoroughly cleaning the skin with an appropriate disinfectant. Insert the entire length of the needle subcutaneously and fully depress the syringe plunger. Slowly withdraw the needle while pressing the skin at the insertion site. Examine the syringe and needle to ascertain that the implant has not remained within the syringe or needle. It may be possible to palpate the implant in situ.

The implant is absorbed and does not require removal.

Do not attempt to re-use the implanter.

In safety and tolerance studies, the only systemic adverse effect seen in mares receiving up to 10 implants simultaneously was suppression of ovarian activity.

Withdrawal periods:
Meat and offal: 7 days. Do not use in mares producing milk for human consumption.

Pharmacodynamic properties:
Deslorelin is a synthetic oligopeptide analogue of gonadotropin releasing hormone used to advance ovulation in oestrus mares. The mechanism of action of deslorelin corresponds with that of naturally occurring GnRH, stimulating the release of follicle stimulating hormone and luteinising hormone (LH) from the pituitary gland. The increased circulating concentration of LH promotes ovulation in mares with a developing follicle greater than 30 mm in diameter. The use of an implant formulation which releases deslorelin over a short time period results in a pre-ovulatory peak of LH within a narrow time frame, thereby inducing ovulation within 48 hours in a high proportion of mares. The advancement of ovulation in this way decreases the duration of oestrus and allows closer synchronisation of mating with ovulation.

Pharmacokinetic properties:
No direct measurement of deslorelin release in vivo has been carried out in the target species. Due to the mode of action and rapid metabolism of deslorelin, direct measurement of the substance in plasma is not practicable. To overcome this, indirect markers of deslorelin have been used by assaying blood concentrations of LH and FSH. The observation of increased LH and FSH concentrations in blood at 12–48 hours after implantation provides indirect evidence that release of deslorelin is occurring.

Pharmaceutical particulars:
Shelf life:
Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
Special precautions for storage
Store in a refrigerator (2°C - 8°C).

Immediate packaging:
The implant is supplied preloaded in a polypropylene syringe with an attached stainless steel needle. Each preloaded implanter is supplied in a sealed foil pouch. 5 of these are packaged in a cardboard carton.

Any unused product or waste materials should be disposed of in accordance with national requirements.

Data Sheets

OVUPLANT: Data Sheet

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