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Osphos 51mg/ml Solution for Injection 15ml

Item Number: OSPHOSINJ

Osphos 51mg/ml Solution for Injection 15ml
  • 15ml

    Estimated dispatch on Thursday

    £ 316.89

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Osphos 51mg/ml Solution for Injection for Horses 15ml. Target species: Horses.

Indications for use:
For the alleviation of clinical forelimb lameness associated with the bone resorptive processes of the distal sesamoid (navicular bone) in adult horses.

Do not administer intravenously.

Do not administer to horses less than 4 years of age, due to the absence of data regarding use in growing animals.

Do not administer to horses with impaired renal function.

Do not use in cases of known hypersensitivity to the active substance or to any of the excipients.

Special precautions for use in animals:
Use caution when administering bisphosphonates to horses with conditions affecting mineral or electrolyte homeostasis, e.g. hyperkalaemic periodic paralysis, hypocalcaemia.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Accidental self-injection of this product may increase the risk of obstructed labour in pregnant women and affect fertility in men.

Care should be taken when handling the product to avoid self-injection.

In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician.

Adverse reactions:
In a clinical field study, administration of clodronic acid at 1.19 mg/kg to 142 horses resulted in the following frequency of adverse reactions: nervousness, lip licking, yawning and colic were common; head bobbing, transient swelling at the injection site, pawing the ground, hives and pruritus were uncommon.

The frequency of adverse reactions is defined using the following convention:

- common (more than 1 but less than 10 animals in 100 animals displaying adverse reactions during the course of one treatment)

- uncommon (more than 1 but less than 10 animals in 1,000 animals)

Use during pregnancy, lactation or lay:
Laboratory studies in rats and rabbits have shown evidence of maternotoxic effects, especially during late gestation stages. Laboratory studies in rats and rabbits have not produced any evidence of teratogenic or foetotoxic effects.

The safety of the veterinary medicinal product has not been studied in pregnant or lactating mares. The use of the product during pregnancy or lactation in mares is not recommended.

Medications such as aminoglycosides whose toxicity can be exacerbated by a reduction in serum calcium, and medications such as tetracyclines that can reduce serum calcium should not be given for 72 hours after administration of clodronic acid.

Amounts to be administered and administration route:
Intramuscular injection only. 1.53 mg clodronic acid per kg body weight, corresponding to 3 ml per 100 kg body weight. Divide the total volume evenly for administration at 2 to 3 separate injection sites.

The maximum dose is 765 mg clodronic acid per horse (one 15 ml vial per horse > 500 kg). Do not exceed the recommended dose.

Adverse reactions may occur when the dose is exceeded. At 2X, 3X and 5X the dose, flehming, head shaking, neck retching, pawing, agitation, depression, muscle fasciculation and colic may be observed. A dose related trend for increases in blood urea nitrogen (BUN) and creatinine may also occur. At 5X dosing of clodronic acid, 3 our of 6 horses developed temporary gait abnormalities including hypermetria, spasticity or mild ataxia. Erosions of the glandular mucosa have been observed in 2 out of 8 animals administered 3X the recommended treatment dose. This was not observed in the 1X or 2X groups.

In one of 8 horses administered 3X the recommended treatment dose a 3 cm diameter area of muscle atrophy was observed at one of the injection sites.

In a clinical safety study conducted in 48 animals, signs of colic were observed in 94 % of animals administered 3X the recommended treatment dose. In most cases, repeated hand walking was adequate to alleviate symptoms. Monthly administration of a 1X dose for a total of six months did not lead to signs of overdose.

Withdrawal periods:
Meat and offal: Zero days.

Not authorised for use in animals producing milk for human consumption.

Pharmacodynamic properties:
Clodronic acid is a geminal bisphosphonate that inhibits bone resorption by binding to hydroxyapatite crystals (inhibiting their formulation and dissolution), and by direct cellular effects on osteoclasts (inhibiting osteoclast cell function). It has a high affinity for solid-phase calcium phosphate and therefore accumulates in bone, where it inhibits the formulation, aggregation and dissolution of calcium phosphate crystals. Bound to bone matrix, clodronic acid enters resorbing osteoclasts, alters their morphology and reduces the number of active osteoclasts, regardless of the cause of osteoclast activity. Clodronic acid increases bone mass by inhibiting bone resorption and retarding bone turnover.

Pharmacokinetic properties:
The pharmacokinetic profile after a single intramuscular administration of 765 mg clodronic acid in horses diagnosed with navicular syndrome is characterised by rapid absorption of clodronic acid and a longer terminal elimination phase. The plasma half-life is approximately 11.8 hours ± 12.5 hours (mean ± standard deviation), Cmax is 7.5 ± 1.7 µg/ml and time to maximum concentration (Tmax) is approximately 0.6 hours.

Pharmaceutical particulars:
Major incompatibilities:
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

Shelf life:
Shelf life of the veterinary medicinal product as packaged for sale: 2 years.

For single use only; any remaining product should be discarded.

Special precautions for storage:
Keep the container in the outer carton.
Do not store above 30° C.

Immediate packaging:
Clear glass (type I) vial with chlorobutyl rubber stopper, an aluminium seal and a plastic flip-off cap containing 15 ml of clodronic acid solution.

Each cardboard box contains 1 vial.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Data Sheets



Shipping charges mainland UK zone1

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Under £49.00Under 250g£2.99

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