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Noropraz Horse Wormer Paste

Item Number: NOROPRAZ

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  • Noropraz Horse Wormer Paste

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    Web code: E2636

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Description

For a complete list of products please go to our horse wormers department.

Noropraz Horse Wormer Paste. For the treatment of mixed cestode and nematode or arthropod infestations, due to adult and immature roundworms, lungworms, bots and tapeworms in horses.

Apple flavoured oral paste containing Ivermectin and Praziquantel. Each syringe treats 700kg bodyweight.

Do not use in foals under 2 weeks of age.

Withdrawal Period
Horses: Meat & Offal: 35 days
Not permitted for use in horses producing milk for human consumption.

Can be used during pregnancy and lactation.


Data Sheets

Noropraz, 18.7 mg/g + 140.3 mg/g Oral Paste for Horses Species:Horses and other equidae

Therapeutic indication:Pharmaceuticals: Endoparasiticides: Anthelmintics for horses

Active ingredient:Ivermectin, Praziquantel

Product:Noropraz, 18.7 mg/g + 140.3 mg/g Oral Paste for Horses

Product index:Noropraz Oral Paste

Withdrawal notes:Horse: Meat & Offal 35 days/Not permitted for use in horses producing milk for human consumption

Qualitative and quantitative composition

Each gram contains:

Active substance:

Ivermectin 18.7 mg

Praziquantel 140.3 mg

Excipient(s):

Titanium Dioxide (E171) 20 mg

For a full list of excipients, see section "Pharmaceutical Particulars"

Pharmaceutical form

Oral paste

A white to off white homogenous paste

Clinical particulars

Target species

Horses

Indications for use, specifying the target species

For the treatment of mixed cestode and nematode or arthropod infestations, due to adult and immature roundworms, lungworms, bots and tapeworms in horses:

Nematodes:

Large strongyle:

Strongylus vulgaris (adult and arterial larvae), Strongylus edentatus (adult and L4 tissue larval stages), Strongylus equinus (adult), Tridontophorus spp. (adult)

Small strongyle:

Cyathostomum: Cylicocyclus spp., Cylicostephanus spp., Cylicodontophorus spp., Gyalocephalus spp. (adult and non-inhibited mucosal larvae)

Parascaris: Parascaris equorum (adult and larvae)

Oxyuris: Oxyuris equi (larvae)

Trichostrongylus: Trichostrongylus axei (adult)

Strongyloides: Strongyloides westeri (adult)

Habronema: Habronema spp. (adult)

Onchocerca: Onchocerca spp. microfilariae i.e. cutaneous onchocerciasis

Lungworm: Dictyocaulus arnfieldi (adult and larvae)

Cestodes (Tapeworm):

Anoplocephala perfoliata (adult), Anoplocephala magna (adult), Paranoplocephala mamillana (adult)

Dipteran insects:

Gasterophilus spp. (larvae)

Contraindications

Do not use in foals under 2 weeks of age.

Do not use in case of hypersensitivity to the active substances or to any of the excipients.

Special warnings

Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:

- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.

- Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device.

Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

Resistance to ivermectin (an avermectin) has been reported in Parascaris equorum in horses in a number of countries including in the EU. Therefore the use of this product should be based on local (regional farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.

As tapeworm infestation is unlikely to occur in horses before two months of age, treatment of foals below this age is not considered necessary.

Special precautions for use

Special precautions for use in animals

Avermectins may not be well tolerated in all non target animals. Cases of intolerance are reported in dogs, especially Collies, Old English Sheepdogs and related breeds or crosses, and also in turtle and tortoises. Dogs and cats should not be allowed to ingest spilled paste or access to used syringes due to the potential for adverse effects related to ivermectin toxicity.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Wash hands after use.

Do not eat, drink or smoke while handling this product.

Avoid contact with the eyes as the product may cause eye irritation.

In case of accidental eye contact, rinse immediately with plenty of water.

In case of accidental ingestion or eye irritation, seek medical advice and show the package leaflet or label to the physician.

Adverse reactions (frequency and seriousness)

Horses carrying heavy infection of Onchocerca microfilariae have experienced such reactions as swelling and itching after treatment. It is assumed that these reactions are the result of the destruction of large numbers of microfilariae.

In case of very high levels of infestation, destruction of the parasites may cause a mild transient colic and loose faeces in the treated horse.

Colic, diarrhea and anorexia have been reported in very rare occasions post treatment, in particular when there is heavy worm burden.

In very rare occasions, allergic reactions such as hypersalivation, lingual oedema and urticaria, tachycardia, congested mucus membranes, and subcutaneous oedema have been reported following treatment with the product. A veterinarian should be consulted if these signs persist.

The frequency of adverse reactions is defined using the following convention:

- very rare (less than 1 animal in 10,000 animals treated, including isolated reports

Use during pregnancy, lactation or lay

Can be used during pregnancy and lactation.

Interaction with other medicinal products and other forms of interaction

None known.

Amounts to be administered and administration route

For oral use. Single administration.

200 µg of Ivermectin and 1.5 mg of Praziquantel per kg of bodyweight corresponding to 1.07 g of paste per 100 kg bodyweight.

To ensure administration of a correct dose, bodyweight should be determined as accurately as possible and the correct syringe division selected, as underdosing might lead to an increased risk of development of resistance to anthelmintic drugs.

Weight

Dosage Weight Dosage
Up to 100 kg 1.070 g 401 – 450 kg 4.815 g
101 – 150 kg 1.605 g 451 – 500 kg 5.350 g
151 – 200 kg 2.140 g 501 – 550 kg 5.885 g
201 – 250 kg 2.675 g 551 – 600 kg 6.420 g
251 – 300 kg 3.210 g 601 – 650 kg 6.955 g
301 – 350 kg 3.745 g 651 – 700 kg 7.490 g
351 – 400 kg 4.280 g
The first division delivers enough paste to treat 50 kg.

Each subsequent syringe division delivers enough paste to treat 50 kg of bodyweight. The syringe should be adjusted to the calculated dosage by setting the ring on the appropriate place on the plunger.

The syringe contains 7.49 g of paste and delivers sufficient paste to treat 700 kg of bodyweight at the recommended dose rate.

Directions for use

Before administration, adjust the syringe to the calculated dosage by setting the ring on the plunger. The paste is administered orally by inserting the nozzle of the syringe through the interdental space and depositing the required amount of the paste on the back of the tongue. The animal’s mouth should be free of any food. Immediately after administration, elevate the head of the horse for a few seconds to ensure the dose is swallowed.

The veterinary surgeon should give advice regarding appropriate dosing programmes and stock management to achieve adequate parasite control for both tapeworm and roundworm infestations.

Overdose (symptoms, emergency procedures, antidotes), if necessary

A tolerance study performed in foals from 2 weeks of age with doses up to 5 times the recommended dosage showed no adverse reactions.

Safety studies conducted in mares administered 3 times the recommended dosage at 14 day intervals during the whole gestation and lactation did not show any abortions, any adverse effects on the gestation, parturition and on the mares general health, nor any abnormalities on the foals.

Safety studies conducted in stallions administered 3 times the recommended dosage did not show any adverse effects in particular on the reproductive performances.

Withdrawal period(s)

Horses: Meat & Offal: 35 days

Not permitted for use in horses producing milk for human consumption.

Pharmacological particulars

Pharmacotherapeutic group: Endectocides, ivermectin, combinations

ATCvet code: QP 54AA51

Pharmacodynamic properties

Ivermectin is a macrocyclic-lactone derivative which has a broad antiparasitic activity against nematodes and arthropods. It acts by inhibiting nerve impulses. Its mode of action includes the glutamate-gated chloride ion channels. Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the relevant parasites. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels.

Praziquantel is a pyrazinoisoquinoline derivative which exerts its anthelmintic activity against many species of cestodes and trematodes. It primarily acts by impairing both motility and function of the suckers of cestodes. Its mode of action includes the impairing of neuromuscular co-ordination but also influencing the permeability of the integument of the worms, which leads to excessive calcium and glucose loss. This induces spastic paralysis of the parasite musculature.

Pharmacokinetic particulars

After administration of the recommended dosage to horses, the ivermectin plasma peak was reached within 24 hours. The ivermectin concentration was still over 2 ng/ml 14 days after administration. The elimination half-life of ivermectin was 90h.. The elimination half-life of praziquantel was 40 min.

Pharmaceutical particulars

List of excipients

  • Hydrogenated castor oil
  • Hydroxypropylcellulose
  • Titanium dioxide (E171)
  • Apple Flavour
  • Propylene glycol
  • Incompatibilities

    Not applicable

    Shelf life

    Shelf-life of the veterinary medicinal product as packaged for sale: 18 months

    Shelf-life after first opening the immediate packaging: 6 months

    Special precautions for storage

    Do not store above 25°C

    After use, replace cap and store below 25oC.

    Nature and composition of immediate packaging

    An adjustable multidose syringe composed of polyethylene barrel, plunger and end cap, with polypropylene dosing rings. The syringe contains 7.49g of product and is fitted with variable dose capacity.

    The oral paste is available in the following pack sizes:

    - 1 carton box containing 1 x 7.49g syringe

    - 1 carton box containing 2 x 7.49g syringes

    - 1 carton box containing 12 x 7.49g syringes

    - 1 carton box containing 40 x 7.49g syringes

    - 1 carton box containing 48 x 7.49g syringes

    - 1 carton box containing 50 x 7.49g syringes

    Not all pack sizes may be marketed.

    Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

    EXTREMELY DANGEROUS FOR FISH AND AQUATIC LIFE. Do not contaminate surface waters or ditches with product or used syringes.

    Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

    Marketing Authorisation Holder (if different from distributor)

    Norbrook Laboratories Limited, Station Works, Newry, Co. Down, BT35 6JP, United Kingdom

    Marketing Authorisation Number

    Vm 02000/4365

    Significant changes

    Date of the first authorisation or date of renewal

    15 October 2013

    Date of revision of the text

    October 2018

    Any other information

    Nil.

    Legal category

    Legal category:POM-VPS

    GTIN

    GTIN description:NoroPraz Paste for Horses: 12x

    GTIN:5023534020004

    GTIN description:NoroPraz Paste for Horses: 1x

    GTIN:5023534019992

    Delivery

    Shipping charges mainland UK zone1

    ValueWeightDelivery Charge
    Over £49.00Any WeightFREE
    Under £49.00No weight limit£4.50
    Under £49.00Under 250g£2.99

    Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

    NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

    Estimated "Usually shipped in" information is shown against most products

    Overseas orders

    Postage outside of the UK is from £4.50

    Prescription Items

    Prescription items will be sent on receipt of a valid signed and dated prescription.

    Pick up

    We offer a pickup service for orders placed over the phone.

    Please ring us on 01833 641112 for more information.

    Refrigerated Items

    Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

    Returns

    We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

    *Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

    Frequently Asked Questions

    Does Noropraz kill adult roundworms and encysted red worms?

    Noropraz will treat roundworm however does not treat encysted small redworm. Equest will treat both of these worms.

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