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Nexmectin Paste Horse Wormer

Item Number: NEXMECTIN

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  • Nexmectin Paste Horse Wormer

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    Web code: Q11257

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Description

Audevard Nexmectin Paste Horse Wormer

Indications for use
Treatment of nematode or arthropod infection due to:
Large strongyles:
• Strongylus vulgaris (adults and L4 stage larvae [arterial])
• Strongylus edentatus (adults and L4 stage larvae [tissue])
• Strongylus equinus (adults)
Small strongyles (including benzimidazole resistant strains):
• Cyathostomum spp. (adults and luminal L4 stage larvae)
• Cylicocyclus spp. (adults and luminal L4 stage larvae)
• Cylicodontophorus spp. (adults and luminal L4 stage larvae)
• Cylicostephanus spp. (adults and luminal L4 stage larvae)
• Gyalocephalus spp. (adults and luminal L4 stage larvae)
Ascarids:
• Parascaris equorum (luminal L5 larvae and adults)
Pinworms:
• Oxyuris equi (L4 stage larvae and adults)
Neck threadworms:
• Onchocerca spp. (microfilariae)
Stomach bots:
• Gasterophilus spp. (oral and gastric stages)


Data Sheets

Nexmectin 18.7 mg/g Oral Paste for Horses Species:Horses and other equidae

Therapeutic indication:Pharmaceuticals: Endoparasiticides: Anthelmintics for horses

Active ingredient:Ivermectin

Product:Nexmectin 18.7 mg/g Oral Paste for Horses

Product index:Nexmectin 18.7 mg/g Oral Paste for Horses

Withdrawal notes:Horses: Meat & Offal: 34 days. Do not use in mares producing milk for human consumption

Qualitative and quantitative composition

Each g contains:

Active substance:

Ivermectin 18.7 mg
Excipient(s):
Titanium dioxide (E171) 20 mg
For full list of excipients, see Pharmaceutical Particulars section.

Pharmaceutical form

Oral Paste. A white homogeneous paste.

Clinical particulars

Target Species

Horses

Indications for use, specifying the target species

Treatment of nematode or arthropod infection due to:

Large strongyles:

  • Strongylus vulgaris (adults and L4 stage larvae) [arterial])
  • Strongylus endentatus (adults and L4 stage larvae [tissue])
  • Strongylus equinus (adults)
  • Small strongyles (including benzimidazole resistant strains):

  • Cyathostomum spp. (adults and luminal L4 stage larvae)
  • Cylicocyclus spp. (adults and luminal L4 stage larvae)
  • Cylicodontophorus spp. (adultsa and luminal L4 stage larvae)
  • Cylicostephanus spp. (adults and luminal L4 stage larvae)
  • Gyalocephalus spp. (adults and luminal L4 stage larvae)
  • Ascarids:

  • Parascaris equorum (luminal L5 larvae and adults)
  • Pinworms:

  • Oxyuris equi (L4 stage larvae and adults)
  • Neck threadworms:

  • Onchocerca spp. (microfilariae)
  • Stomach bots:

  • Gasterophilus spp. (oral and gastric stages)
  • Contraindications

    Do not use in cases of hypersensitivity to the active substance or to any of the excipients. Do not use in dogs or cats as severe adverse reactions may occur.

    Special warnings for each target species

    Some horses with heavy infections of Onchocerca spp. microfilariae have experienced oedema and pruritus following treatment, such reactions are assumed to be the result of death of large numbers of microflariae. These signs resolve within a few days but symptomatic treatment may be advisable.

    Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:

  • Too frequent and repeated use of anthelmintics from the same class over an extended period of time.
  • Underdosing, which may be due to underestimation of body weight or misadministration of the product.
  • Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (eg Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

    Veterinary advice should be given on appropriate dosing programs and stock management to achieve adequate parasite control and reduce the likelihood of anthelmintic resistance developing. In the event that a product is suspected of being ineffective, the animal owner is advised to seek veterinary advice.

    Resistance to ivermectin has been reported in Parascaris equorum. Therefore, the use of this product should be based on local farm epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.

    Special Precautions for Use

    Special precautions for use in animals

    Since ivermectin is highly bound to plasma proteins, special care should be taken in cases of sick animals or in nutritional conditions associated with low plasma protein levels.

    Dogs and cats should not be allowed to ingest spilled gel or have access to used packaging due to the potential for adverse effects related to ivermectin toxicity.

    The product has been formulated for use in horses only. Cats, dogs (especially Collies, Old English Sheepdogs and related breeds or crosses) and also turtles and tortoises may be adversely affected by the concentration of ivermectin in this product if they are allowed to ingest spilled paste or have access to used syringes.

    Special precautions to be taken by the person administering the veterinary medicinal product to animals

    Do not smoke, eat or drink while handling the product.

    Wash hands after use.

    This product may cause skin and eye irritation. Therefore, the user should avoid contact of the product with the skin and the eyes. In case of contact, rinse immediately and show the package leaflet or the label to the physician.

    Adverse Reactions (frequency and seriousness)

    None know.

    Use during pregnancy, lactation

    The product can be administered to mares at any stages of pregnancy or lactation. Do not use in mares producing milk for human consumption.

    Interaction with other medicinal products and other forms of interaction

    The effects of GABA agonists are increased by ivermectin.

    Amounts to be administered and administration route

    Dosage:

    One syringe division of paste per 100 kg body weight (based on a recommended dosage of 200 μg ivermectin per kg body weight).

    The syringe containing 6.42 g of paste delivers sufficient paste to treat 600 kg of bodyweight at the recommended dose rate.

    The syringe containing 7.49 g of paste delivers sufficient paste to treat 700 kg of bodyweight at the recommended dose rate.

    Administration:

    The paste is given by oral route.

    To ensure administration of a correct dose, body weight should be determined as accurately as possible. The animal's mouth should be free from food to ensure swallowing. Turn the screw gauge on the syringe plunger to the body weight of the horse. The tip of the syringe barrel should be inserted at the interdental space (the gap between the front and back teeth) and the paste deposited on the base of the tongue. Advance the plunger as far as it will go, depositing the medication on the base of the tongue. Immediately elevate the horse's head for a few seconds to ensure swallowing.

    Overdose (symptoms, emergency procedures, antidotes), if necessary

    Mild transitory signs (slowed pupillary light response and depression) have been seen at a higher dose of 1.8 mg/kg (9 times the recommended dose level). Other signs seen at higher doses include mydriasis, ataxia, tremors, stupor, coma and death. The less severe signs have been transitory.

    Although no antidote has been identified, symptomatic therapy may be beneficial.

    Withdrawal period(s)

    Meat and offal: 34 days

    Do not use in mares producing milk for human consumption.

    Pharmacological particulars

    Pharmacotherapeutic Group

    Endectocide, macrocyclic lactones

    ATCVet code: QP54AA01

    Pharmacodynamic Properties

    Ivermectin is a member of the macrocyclic lactone class of endectocides. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, which results in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).

    The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels, and macrocyclic lactones do not readily cross the blood-brain barrier.

    Pharmacokinetic Particulars

    Following oral administration of the recommended dose to horses, a mean peak plasma concentration (Cmax) of 33 ng/ml was achieved within 24 hours.

    Ivermectin is well absorbed into the systemic circulation following administration. Only about 2% of the drug is excreted in urine, faecal excretion being the major route of elimination.

    Ivermectin passes readily into milk.

    Pharmaceutical particulars

    List of excipients

    Hydrogenated Castor Oil

    Hydroxypropylcellulose

    Titanium Dioxide (E171)

    Propylene Glycol

    Major Incompatibilities

    Not applicable.

    Shelf life

    Shelf life of the veterinary medicinal product as packaged for sale: 3 years.

    The product is for single use. After use, the syringe should be discarded.

    Special precautions for storage

    Do not store about 25°C

    Nature and composition of immediate packaging

    High density polyethylene dose graduated syringes in an outer cardboard box.

    Pack size:

    Box containing 1 syringe of 6,42g

    Box containing 1 syringe of 7,49 g

    Box containing 50 syringers of 7,49 g

    Not all pack sizes may be marketed.

    Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

    EXTREMELY DANGEROUS TO FISH AND AQUATIC LIFE. Do not contaminate surface waters or ditches with product or used container.

    Any unused veterinary medicinal product or wast materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements

    Marketing Authorisation Holder (if different from distributor)

    Eco Animal Health Ltd, 78 Coombe Road, New Malden, Surrey, KT3 4QS

    Marketing Authorisation Number

    UK : 13277/4028

    Significant changes

    Date of the first authorisation or date of renewal

    11 July 2019

    Date of revision of the text

    July 2019

    Any other information

    Nil.

    Legal category

    Legal category:POM-VPS

    Delivery

    Shipping charges mainland UK zone1

    ValueWeightDelivery Charge
    Over £49.00Any WeightFREE
    Under £49.00No weight limit£4.50
    Under £49.00Under 250g£2.99

    Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

    NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

    Estimated "Usually shipped in" information is shown against most products

    Overseas orders

    Postage outside of the UK is from £4.50

    Prescription Items

    Prescription items will be sent on receipt of a valid signed and dated prescription.

    Pick up

    We offer a pickup service for orders placed over the phone.

    Please ring us on 01833 641112 for more information.

    Refrigerated Items

    Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

    Returns

    We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

    *Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

    Frequently Asked Questions

    Expiry date .

    Current batch is 05/23

    Is this wormer safe for pregnant mares?

    The product can be administered to mares at any stages of pregnancy or lactation. Do not use in mares producing milk for human consumption.

    What are the excipients please.

    List of excipients: Hydrogenated Castor Oil, Hydroxypropylcellulose, Titanium Dioxide (E171), Propylene Glycol

    What are the other ingredients?

    Hydrogenated Castor Oil, Hydroxypropylcellulose, Titanium Dioxide (E171), Propylene Glycol.

    Is this safe for young foals

    This has not been tested on young foals. Panacur Paste is usually recommended for the first few worming's. If you wish to use an Ivermectin based wormer the Eqvalan is suitable for horses and donkeys of all ages. Eqvalan Horse Wormer Paste - from £5.59 | Hyperdrug

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