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Neoprinil Pour On 5mg/ml Solution for Cattle

Item Number: NEOPPOFC

Sale Neoprinil Pour On 5mg/ml Solution for Cattle

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  • 1L

    Estimated dispatch on Friday

    £ 91.35

  • 2.5L

    Was £209.49 Now £192.49

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  • 5L

    £ 323.29

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  • 8L Flexibag

    Estimated dispatch on Friday

    Was £492.95 Now £482.19

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Neoprinil Pour on 5mg/ml solution for cattle.

Indications for use:
Treatment of infestations by the following parasites sensitive to eprinomectin:

Gastrointestinal roundworms (adults and L4 larvae): Ostertagia ostertagi (including inhibited L4 larvae), Ostertagia lyrata (only adults), Haemonchus placei, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia sp. (including inhibited L4), Cooperia oncophora, Cooperia punctata, Cooperia pectinata, Cooperia surnabada, Bunostomum phlebotomum, Nematodirus helvetianus, Oesophagostomum radiatum, Oesophagostomum sp. (only adults), Trichuris discolor (only adults);

Lungworms: Dictyocaulus viviparus (adults and L4);

Warbles (parasitic stages): Hypoderma bovis, Hypoderma lineatum;

Mange mites: Chorioptes bovis, Sarcoptes scabiei var. Bovis;

Sucking lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus;

Biting lice: Damalinia bovis;

Flies: Haematobia irritans.

The product protects the animals against reinfestations with:

- Nematodirus helvetianus for 14 days.

- Trichostrongylus axei and Haemonchus placei for 21 days.

- Dictyocaulus viviparus,,Cooperia oncophora, Cooperia punctata, Cooperia surnabada, Oesophagostomum radiatum and Ostertagia ostertagi for 28 days.

This product is formulated only for topical application to beef and dairy cattle, including lactating dairy cattle. Do not use in other animal species.

Do not administer orally or by injection.

Do not use in case of resistance to the active ingredient.

Do not use in animals with known hypersensitivity to the active ingredient or to any of the excipients.

Special warnings for each target species

Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:

- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.

- Underdosing, which may be due to underestimation of bodyweight, misadministration of the product, or lack of calibration of the dosing device (if any).

Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

To date no resistance to eprinomectin (a macrocyclic lactone) has been reported in cattle within the EU. However resistance to other macrocyclic lactones has been reported in parasite species in cattle within the EU. Therefore, use of this product should be based on local (regional, farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.

Special precautions for use:
i) Special precautions for use in animals

For external use only.

To avoid adverse reactions due to the death of warble larvae in the oesophagus or backbone, it is recommended to administer the product after the end of the swarming of the warbles and before the larvae reach their sites in the body; consult a veterinary surgeon to know the appropriate treatment period.

Not to be used in other species; avermectins can cause fatalities in dogs, especially Collies, Old English Sheepdogs and related breeds and crosses, and also in turtles/tortoises.

For effective use, the product should not be applied to areas of the backline covered with mud or manure. The product should be applied only on healthy skin.

ii) Special precautions to be taken by the person administering the veterinary medicinal product to animals

Avoid direct contact with the skin or eyes.

Wear rubber gloves and protective clothing when applying the product.

If accidental skin contact occurs, wash the affected area immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water.

Wash hands after use.

Do not smoke, eat or drink while handling the product.

Should clothing become contaminated, remove as soon as possible and wash before re-use. In the event of ingestion, wash out mouth with water and seek medical advice.

People with known hypersensitivity to the active substance or to any of the excipients should avoid contact with the veterinary medicinal product.

iii) Other precautions

Eprinomectin is very toxic to dung fauna and aquatic organisms and may accumulate in sediments. Eprinomectin is persistent in soils.

The risk to aquatic ecosystems and dung fauna can be reduced by avoiding too frequent and repeated use of eprinomectin (and products of the same anthelmintic class) in cattle.

The risk to aquatic ecosystems will be further reduced by keeping treated cattle away from water bodies for three weeks after treatment.

Adverse reactions:
Transient licking reactions, skin tremor at the administration site, minor local reactions such as the occurrence of dandruff and skin scales at the administration site have sometimes been observed.

Use during pregnancy, lactation or lay:
Laboratory studies (rat, rabbit) have not produced any evidence of a teratogenic or embryotoxic effects due to the use of eprinomectin at therapeutic doses. The safety of the veterinary medicinal product in cattle has been established during pregnancy and lactation and in reproductive bulls. Can be used during pregnancy and lactation as well as in reproductive bulls.

Since eprinomectin binds strongly to plasmatic proteins, this should be taken into account if it is used in association with other molecules having the same characteristics.

Amounts to be administered and administration route:
Pour-on use.

To be administered topically in one single treatment at the dose rate of 500 µg eprinomectin per kg bodyweight equivalent to 1 ml per 10 kg bodyweight.

Apply the pour-on solution along the mid-line of the back in a narrow strip between the withers and tail head.

To ensure administration of a correct dose, bodyweight should be determined as accurately as possible and accuracy of the dosing device should be checked. If animals are to be treated collectively rather than individually, they should be grouped according to their bodyweight and dosed accordingly, in order to avoid under- and overdosing.

All the animals belonging to the same group should be treated at the same time.

FlexiBag (2.5 litre, 4.5 litre and 8 litre flexible pouch)

Connect an appropriate dosing gun to the FlexiBag as follows.

1 to 4. Connect one side of the tube to the coupling E-lock system draw-off and the other side to the dosing gun.

5 and 6. Plug the E-lock coupling system to the FlexiBag.

7. Gently prime the dosing gun, checking before use that all connections are tight.

Follow the gun manufacturer’s instructions for adjusting the dose and proper use and maintenance of the dosing gun.

When body weight is between marking, use the higher setting.

No signs of toxicity have been observed after administration of up to 5 times the recommended dose. No specific antidote has been identified.

Withdrawal periods:
Meat and offal: 15 days.

Milk: zero hours.

Pharmacological particulars

Pharmacodynamic properties:
Eprinomectin is a molecule with an endectocidal activity belonging to the macrocyclic lactone class. Compounds of the class bind with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve or muscle cells. These compounds bind selectively to these channels, which leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.

Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).

Pharmacokinetic properties:
The bioavailability of topically applied eprinomectin in cattle is about 30% with most absorption occurring within 10 days after treatment. Eprinomectin is not extensively metabolized in cattle following topical administration. In all biological matrices, the B1a component of eprinomectin is the single most abundant residue.

Eprinomectin consists of the components B1a (= 90%) and B1b (= 10%) which differ by a methylene unit and is not extensively metabolized in cattle. Metabolites amount to approximately 10% of the total residues in plasma, milk, edible tissues and faeces.

The metabolism profile is nearly identical, qualitatively and quantitatively, in the above biological matrices and does not change significantly with time after administration of eprinomectin. The percent contribution of B1a and B1b to the overall metabolite profile remains constant. The ratio of the two drug components in the biological matrices is identical to that in the formulation demonstrating that the two eprinomectin components are metabolized with nearly equal rate constants. Since the metabolism and the tissue distribution of the two components are quite similar, the pharmacokinetics of the two components would be also similar.

Eprinomectin is strongly linked to plasma proteins (99%). Faeces is the major route of elimination.

Environmental properties:
Like other macrocyclic lactones, eprinomectin has the potential to adversely affect non-target organisms. Following treatment, excretion of potentially toxic levels of eprinomectin may take place over a period of several weeks. Faeces containing eprinomectin excreted onto pasture by treated animals may reduce the abundance of dung feeding organisms which may impact on the dung degradation. Eprinomectin is very toxic to aquatic organisms and may accumulate in sediments. Eprinomectin is persistent in soils.

Major incompatibilities:
Do not mix with any other veterinary medicinal product.

Shelf life:
Shelf-life of the veterinary medicinal product as packaged for sale: 2 years.

Shelf-life after first opening the immediate packaging (pouches): 2 years.

Special precautions for storage:
This veterinary medicinal product does not require any special storage conditions.

Immediate packaging:
2.5 litres, 4.5 litres and 8 litres multi-layer PET/aluminium/PA/PE flexible pouches with a PP cap and its specific coupling POM “E-lock”.

Extremely dangerous to fish and aquatic life. Do not contaminate ponds, waterways or ditches with the product or empty container. Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.


Data Sheets

NEOPPOFC 25L: Data Sheet

NEOPPOFC 8L: Data Sheet


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ValueWeightDelivery Charge
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Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

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We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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