Free UK Delivery on orders over £49

Linco-Sol 400 mg/g powder for use in drinking water 150g

Item Number: LINCOSOL

Linco-Sol 400 mg/g powder for use in drinking water 150g
  • 150g

    In Stock

    £ 25.05

    Web code: Q11225

Total: £0.00

Choose quantity to add to basket

You are ordering a PRESCRIPTION ONLY medicine. Please do NOT continue unless you are sending us a valid prescription.



Browse other products from the Unbranded product range


Treatment of infection caused by mycoplasma and bacteria susceptible to lincomycin for example:
Pigs: swine dysentery caused by Brachyspira hyodysenteriae and mycoplasma pneumonia associated with Mycoplasma hyopneumoniae.
Chicken: necrotic enteritis caused by Clostridium perfringens.

Data Sheets

1. NAME OF THE VETERINARY MEDICINAL PRODUCT Linco-Sol 400 mg/g powder for use in drinking water for pigs and chickens
2. QUALITATIVE AND QUANTITATIVE COMPOSITION Active substance: Lincomycin (as hydrochloride) 400 mg/g Excipient: For the full list of excipients, see section 6.1.
3. PHARMACEUTICAL FORM Powder for use in drinking water. White or almost white powder.
4.1 Target species Swine and chicken (broiler)
4.2 Indications for use, specifying the target species Pigs Treatment and metaphylaxis of enzootic pneumonia caused by Mycoplasma hyopneumoniae. The presence of the disease in the group must be established before the product is used. Chickens Treatment and metaphylaxis of necrotic enteritis caused by Clostridium perfringens. The presence of the disease in the group must be established before the product is used.
4.3 Contraindications Do not use in cases of hypersensitivity to the active substance or to any of the excipients. Do not use if resistance to lincosamides has been detected. Do not administer to horses, ruminants, guinea pigs, hamsters, chinchilla and rabbits. Ingestion by these species may result in severe gastrointestinal effects. Do not use in cases of hepatic dysfunction.
4.4 Special warnings for each target species Medicated drinking water uptake can be affected by the severity of the disease. In case of insufficient uptake of water, animals should be treated parenterally. The susceptibility of Mycoplasma hyopneumoniae to antimicrobial agents is difficult to test in vitro owing to technical constraints. In addition, there is a lack of clinical breakpoints for Revised: July 2021 AN: 00290/2021 and 00292/2021 Page 2 of 6 both M. hyopneumoniae and C. perfringens. Where possible, therapy should be based on local (regional, farm level) epidemiological information concerning the response of enzootic pneumonia/necrotic enteritis to treatment with lincomycin.
4.5 Special precautions for use Special precautions for use in animals Use of the veterinary medicinal product preferably should be based on identification of the target pathogen and susceptibility testing of the bacteria isolated from the animal. However, also see text under section 4.4. Official, national and regional antimicrobial policies should be taken into account when the veterinary medicinal product is used. Use of the veterinary medicinal product deviating from the instructions given in the summary of product characteristics may increase the prevalence of bacteria resistant to the lincomycin and may decrease the effectiveness of treatment with other lincosamides, macrolides and streptogramin B due to the potential for cross-resistance. Repeated or prolonged use should be avoided by improving the farm management and hygiene practices. Special precautions to be taken by the person administering the veterinary medicinal product to animals This product contains lincomycin and lactose monohydrate, either of which can cause allergic reactions in some people. People with known hypersensitivity to lincomycin or any other lincosamide or to lactose monohydrate, should avoid contact with the veterinary medicinal product. Care should be taken not to raise and inhale any dust. The wearing of approved dust masks (either a disposable half-mask respirator conforming to European Standard EN 149 or a non-disposable respirator to European Standard EN 140 with a filter to EN 143), gloves and safety glasses are recommended whilst reconstituting or administering the solution. Direct contact of the product with the skin, eyes and mucous membranes should be avoided. In case of accidental exposure to the skin, eyes or mucous membranes, rinse abundantly with water. In case of allergic reaction (inflammation of the face, lips or eyes or respiratory difficulties) during reconstituting or administering of the product, seek medical advice immediately and show the package leaflet or the label to the physician. Do not smoke, eat or drink when handling the product. Wash hands and any exposed skin with soap and water immediately after use.
4.6 Adverse reactions (frequency and seriousness) On rare occasions Lincomycin may cause transient soft stools and/or mild swelling of the anus within the first two days of treatment in pigs. On rare occasions some pigs may show reddening of skin and mild irritable behaviour. These conditions are usually self-correcting within 5-8 days without discontinuing lincomycin treatment. Allergic/hypersensitive reactions occur on rare occasions. The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reactions) - common (more than 1 but less than 10 animals in 100 animals treated) Revised: July 2021 AN: 00290/2021 and 00292/2021 Page 3 of 6 - uncommon (more than 1 but less than 10 animals in 1,000 animals treated) - rare (more than 1 but less than 10 animals in 10,000 animals treated) - very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
4.7 Use during pregnancy, lactation or lay Laboratory studies in rats have not produced any evidence of teratogenic effects, although foetotoxicity has been reported. The safety of the veterinary medicinal product has not been established during pregnancy, lactation or lay in the target species. Use only in accordance with benefit/risk assessment by the responsible veterinarian.
4.8 Interaction with other medicinal products and other forms of interaction Antagonism may exist between lincomycin and macrolides such as erythromycin and other bactericidal antibiotics; concurrent use is therefore not recommended due to competitive binding at the 50S ribosomal subunit of the bacterial cell. The bioavailability of lincomycin may decrease in the presence of gastric antacids or activated charcoal, pectin or kaolin. Lincomycin can potentiate neuromuscular effects of anaesthetics and muscle relaxants.
4.9 Amounts to be administered and administration route For use in drinking water. Dosage: Swine: Enzootic pneumonia: 10 mg lincomycin per kg of body weight for 21 consecutive days. Chicken (boiler) Necrotic enteritis: the daily dose is 5 mg lincomycin per kg of body weight for 7 consecutive days. Administration: To be administered orally, in the drinking water. Swine: The product should be administered continuously in the drinking water. In pigs, administration of 33 mg lincomycin per litre containing to the completion of drinking water by dissolving 100 g of product in 1200 litres of water. When using a water proportioner, prepare a stock solution by dissolving 100 g of product in 12 litres of water. Set the proportioner to deliver 10 ml of stock solution per litre of drinking water. Chicken (broiler): The concentration to be used depends on the actual body weight and the water consumption of the animals and can be calculated as follows: product per kg body weight and day x Average chicken body weight (kg) Average daily water intake (litre/animal) product per litre of drinking water To ensure a correct dosage body weight should be determined as accurately as possible to avoid underdosing. The intake of medicated water depends on the physiological and clinical condition of the animals. In order to obtain the correct dosage the concentration of Revised: July 2021 AN: 00290/2021 and 00292/2021 Page 4 of 6 Lincomycin has to be adjusted accordingly. The uptake of water should be monitored frequently. The medicated water should be the only source of drinking water, throughout the treatment period. Medicated water should be refreshed every 24 hours. After the end of the medication period, the water supply system should be cleaned appropriately to avoid intake of sub-therapeutic amounts of the active substance.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary Lincomycin has a good margin of safety, but higher levels of dosage than recommended may cause diarrhoea and loose stools in pigs. In case of accidental overdose, the treatment must be stopped and restarted at the recommended dose level. There is no specific antidote, treatment is symptomatic.
4.11 Withdrawal period(s) Meat and offal of swine: 1 day Meat and offal of chicken (broiler): 5 days Not authorised for use in laying birds producing eggs for human consumption.
5. PHARMACOLOGICAL PROPERTIES Pharmacotherapeutic group: Antibacterials for systemic use; Lincosamides. ATC vet code: QJ01FF02
5.1 Pharmacodynamic properties Lincomycin is a lincosamide antibiotic produced by Streptomyces lincolensis. Lincomycin is bacteriostatic in action inhibiting the protein synthesis predominantly by binding to the 50S ribosomal subunits of bacteria. Depending on the sensitivity of micro-organisms, and on the concentration of the active substance the protein synthesis inhibition antibacterial action can either be bacteriostatic or bactericide. Lincomycin is active against a wide range of Gram-positive micro-organisms, including also anaerobic bacteria such as clostridia and Brachyspira spp., as well as Mycoplasma spp. Lincomycin has no activity against Gram-negative bacteria, such as Klebsiella spp., Pasteurella spp. and Salmonella spp. Resistance to lincomycin is frequently conferred by plasmid-borne factors (erm genes) coding for methylases modifying the ribosomal binding site and frequently leading to cross[1]resistance to other antimicrobials of the macrolides, lincosamides and streptogramins group. However, the most prevalent mechanism in mycoplasmas is the alteration of the binding site through mutational events (chromosomal resistance). Lincomycin resistance mediated by efflux pumps, or by inactivating enzymes, has also been described. There is often complete cross-resistance between lincomycin and clindamycin. Revised: July 2021 AN: 00290/2021 and 00292/2021 Page 5 of 6
5.2 Pharmacokinetic particulars Systemic bioavailability of lincomycin is approximately 53% after oral administration in pigs. Lincomycin is rapidly absorbed orally and reaches therapeutic plasma concentration. After a single, oral administration of approximately 4.4 mg/kg and 11 mg/kg lincomycin to pigs resulted therapeutic plasma concentration for 12-16 hours, reaching peak plasma concentration after 4 hours. After a single, oral dose of 10 mg/kg lincomycin to pigs the maximum plasma concentration (Cmax) of 1.45 mg/kg was reached at 3.6 hours (Tmax). The elimination half life (T1/2β) is about 3.36 hours. The oral administration of 22 mg/kg lincomycin for 3 days to pigs did not result in drug accumulation after 24 hours of administration and there was no therapeutic plasma concentration. After oral administration the absorbed lincomycin is eliminated through the bile and faeces in active form or as metabolites. Lincomycin is also excreted in the milk. Lincomycin reaches the inflammation site by polymorf neutrophil granulocytes that explains its fast absorption and distribution, efficient penetration and targeted activity in difficult to reach tissues. Chickens were administered lincomycin hydrochloride in the drinking water at a level of approximately 34 mg/litre (5.1-6.6 mg/kg body weight) for seven days. Metabolites comprised more than 75% of total residues in the liver. Unmetabolised lincomycin declined at a slightly faster half-life (t½ = 5.8 hours) than total residue. Lincomycin and one unknown metabolite comprised >50% of the muscle residue at zero hours. The excreta contained mostly unmetabolised lincomycin (60-85%) during treatment.
5.3 Environmental properties Lincomycin is known to be toxic to terrestrial plants after application of slurry/manure from treated weaner pigs, fattening pigs and broiler.
6.1 List of excipients Lactose monohydrate.
6.2 Major incompatibilities In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.
6.3 Shelf life Shelf life of the veterinary medicinal product as packaged for sale: 2 years Shelf life after first opening the immediate packaging: 3 months Shelf life after dilution or reconstitution according to directions: 24 hours
6.4 Special precautions for storage Do not store above 25°C. Revised: July 2021 AN: 00290/2021 and 00292/2021 Page 6 of 6 Store in the original container tightly closed in order to protect from moisture.
6.5 Nature and composition of immediate packaging 150 g polypropylene container with polypropylene lid and inner bag of LDPE. 1.5 kg polypropylene container with polypropylene lid and inner bag of LDPE. 5 kg polypropylene container with polypropylene lid and inner bag of LDPE. Not all pack sizes may be marketed.
6.6 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
7. MARKETING AUTHORISATION HOLDER Lavet Pharmaceuticals Ltd. 2143 Kistarcsa Batthyány u. 6. Hungary
10. DATE OF REVISION OF THE TEXT July 2021 Approved: 02/07/21


Shipping charges mainland UK zone1

ValueWeightDelivery Charge
Over £49.00Any WeightFREE
Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.


We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

Frequently Asked Questions

There have been no questions/answers for this product so far.

Ask Question

Ask a question about Linco-Sol 400 mg/g powder for use in drinking water 150g