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Libeo Flavour 10mg tablets for dogs

Item Number: LIBEO10MG

Libeo Flavour 10mg tablets for dogs

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For the treatment of ascites and oedema, particularly associated with cardiac insufficiency in dogs.

Data Sheets

Libeo® 10 mg and 40 mg chewable tablets for dogs Species:Dogs

Therapeutic indication:Pharmaceuticals: Diuretics

Active ingredient:Frusemide (Furosemide)

Product:Libeo® 10 mg and 40 mg chewable tablets for dogs

Product index:Libeo

Qualitative and quantitative composition

Active substance:

One tablet of 330 mg contains: Furosemide 10 mg

One tablet of 1320 mg contains: Furosemide 40 mg


For the full list of excipients, see Pharmaceutical particulars.

Pharmaceutical form

Chewable tablet. Clover shape beige tablet. The tablets can be divided into equal quarters

Clinical particulars

Target species


Indications for use, specifying the target species

Treatment of ascites and oedema, particularly associated with cardiac insufficiency


Do not use in dogs suffering from hypovolaemia, hypotension or dehydration.
Do not use in cases of renal failure with anuria.
Do not use in cases of electrolyte deficiency.
Do not use in cases of hypersensitivity to furosemide, sulfonamides or any of the excipients.

Special warnings for each target species

Therapeutic efficacy may be impaired by increased intake of drinking water. Where the animal’s condition permits, water intake should be restricted to physiologically normal levels during treatment.

Special precautions for use

Special precautions for use in animals
As the tablets are flavoured, they should be stored in a safe place out of the reach of animals.
Furosemide should be used with caution in case of pre-existing electrolyte and/or water imbalance, impaired hepatic function (may precipitate hepatic coma) and diabetes mellitus. In case of prolonged treatment, hydration status and serum electrolytes should be monitored frequently.
1-2 days before and after commencement of treatment with diuretics and ACE inhibitors renal function and hydration status should be monitored.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
People with known hypersensitivity to furosemide should avoid contact with the veterinary medicinal product. Wash hands after use.
Do not handle this product if you know you are sensitive to sulphonamides as hypersensitivity to sulphonamides may lead to hypersensitivity to furosemide. If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention.

In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.

Adverse reactions (frequency and seriousness)

Cross-reactivity to sulfonamides is possible.
In rare cases, soft faeces may occur. These signs are transient and mild and do not necessitate the withdrawal of the treatment.
Due to the diuretic action of furosemide, there may be hemoconcentration and impairment of the circulation. In cases of prolonged treatment electrolyte deficiency (including hypokalemia, hyponatremia) and dehydration may occur.

Use during pregnancy, lactation or lay

Laboratory studies have produced evidence of teratogenic effects.

The safety of the product has not been established in pregnant and lactating bitches however, furosemide is excreted into milk.
In pregnant and lactating animals, use only according to the benefit/risk assessment by the responsible veterinarian.

Interaction with other medicinal products and other forms of interaction

Concurrent use with drugs affecting electrolyte balance (corticosteroids, other diuretics, amphotericin B, cardiac glycosides) requires careful monitoring.
Concomitant use with aminoglycosides or cephalosporins may increase the risk of nephrotoxicity .
Furosemide may increase the risk of sulfonamide allergy.
Furosemide may alter insulin requirements in diabetic animals.
Furosemide may reduce the excretion of NSAIDs.
The dose regimen may need to be modified for long term treatment in combination with ACE inhibitors, depending upon the animal’s response to therapy.

Amounts to be administered and administration route

Oral route.
1 to 5 mg furosemide/kg bodyweight per day, given in a single dose or in two divided daily doses. Depending on the severity of the oedema or ascites or in refractory cases, the daily dose may be doubled.

Example for a targeted dose of 1mg/kg per administration

Weight (kg)

Tablet per administration (10mg)
2 - 3,5 1⁄4
3,6 - 5 ½
5.1 - 7.5 3⁄4
7.6 - 10 1
10.1 - 12.5 1 1⁄4
12.6 - 15 1 ½
Weight (kg) Tablets per administration (40mg)
7,6 - 10 1⁄4
10,1 - 12,5 USE LIBEO 10MG
12,6 - 15 USE LIBEO 10MG
15,1 - 20 ½
20,1 - 30 3⁄4
30,1 - 40 1
40,1 - 50 1 1⁄4
For dogs of 2 to 7.5 and dogs of 10.1 to 15 kg bodyweight, use Libeo 10 mg tablets.

For dogs of 15.1 to 50 kg bodyweight use Libeo 40 mg tablets

For maintenance, the dosage should be adapted to the lowest effective dose by the veterinarian depending on the clinical response of the dog to the therapy.
The dosage and schedule may have to be adjusted depending on the condition of the animal
If treatment is administered last thing at night this may result in inconvenient diuresis overnight.
Instruction on how to divide the tablet: Put the tablet on a plain surface, with its scored side facing the surface (convex face up). With the tip of forefinger, exert a slight vertical pressure on the middle of the tablet to break it in its width into halves. In order to obtain quarters, then exert a slight pressure on the middle of one half with forefinger to break it in its length.

The tablets are flavoured and may be mixed with a small amount of food offered prior to the main meal, or administered directly into the mouth.

Overdose (symptoms, emergency procedures, antidotes), if necessary

Doses higher than recommended may cause transitory deafness, electrolyte and water balance problems CNS effects (lethargy, coma, seizures) and cardiovascular collapse.
Treatment should be symptomatic.

Withdrawal period(s)

Not applicable.

Pharmacological particulars

Pharmacotherapeutic group: Diuretics, furosemide. ATCvet code: QC03CA01

Pharmacodynamic properties

Furosemide is a potent loop diuretic that increases urinary volume. It inhibits electrolyte resorption in the proximal and distal renal tubules and in the ascending Loop of Henle. Excretion of sodium ions, chloride ions and to a lesser extent, potassium ions is enhanced, as is water excretion. Furosemide has no effect on carbonic anhydrase.

Pharmacokinetic particulars

Furosemide is excreted unchanged in the urine.
After oral administration of the product (5 mg/kg), furosemide is rapidly absorbed with maximum plasma levels (Cmax of 2126 ng/mL) occurring within 1.1 hour. The terminal half life of elimination is 2.6 hours.
Furosemide is predominantly eliminated via the kidneys in the urine (70%) and via the faeces. Plasma protein binding of furosemide is 91% and estimated distribution volume is 0,52 L/kg. Furosemide metabolizes in very small amounts (main metabolite: 4-chloro-5-sulfamoyl-anthranilic-acid, no diuretic activity).

In dogs, after oral administration, furosemide causes a dose-dependent increase in urine volume starting 1 hour after administration, reaching a maximum 2-3 hours post administration and lasting approximately 6 hours.

Pharmaceutical particulars

List of excipients

Chicken flavour, Yeast extract (Saccharomices cerevisiae), Maltodextrin, Magnesium stearate, Silica, colloidal anhydrous, Microcrystalline cellulose, Sodium croscarmellose, Lactose monohydrate

Major Incompatibilities

Not applicable

Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale:

Libeo 10mg tablets: 30 months

Libeo 40mg tablets: 3 years

Any part-used tablet should be used within 72 hours

Special precautions for storage

Do not store above 30°C.

Any part-used tablet should be returned to the opened blister

Nature and composition of immediate packaging

Libeo 10 mg:

(white PVC –PVDC – aluminium heat sealed) containing 10 tablets per blister

Cardboard box of 10 tablets containing 1 blister of 10 tablets

Cardboard box of 20 tablets containing 2 blisters of 10 tablets

Cardboard box of 100 tablets containing 10 blisters of 10 tablets

Cardboard box of 120 tablets containing 12 blisters of 10 tablets

Cardboard box of 200 tablets containing 20 blisters of 10 tablets

Libeo 40 mg:

(white PVC-PVDC - aluminium heat sealed) containing 8 tablets per blister

Cardboard box of 8 tablets containing 1 blister of 8 tablets

Cardboard box of 16 tablets containing 2 blisters of 8 tablets

Cardboard box of 96 tablets containing 12 blisters of 8 tablets

Cardboard box of 120 tablets containing 15 blisters of 8 tablets

Cardboard box of 200 tablets containing 25 blisters of 8 tablets

Not all pack sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Marketing Authorisation Number

UK: Vm 15052/4104 - 4105

Significant changes

Date of the first authorisation or date of renewal

04 March 2014

Date of revision of the text

December 2018

Any other information


Legal category

Legal category:POM-V


GTIN description:Libeo 10 mg 12X10T


GTIN description:Libeo 40 mg 15X8T



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Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

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