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Lactovac Suspension for injection for Cattle 25ml (5 dose)

Item Number: LACTOVACI

Lactovac Suspension for injection for Cattle 25ml (5 dose)

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For the active immunisation of pregnant cows and heifers in order to confer passive protection to their calves (via colostrum) to reduce the severity and duration of neonatal diarrhoea caused by rotavirus, coronavirus and E. coli infections.

Protection is conferred only while the calves are fed colostrum from vaccinated cows.

Data Sheets

Lactovac suspension for injection Species:Cattle

Therapeutic indication:Immunological veterinary medical products: For cattle

Active ingredient:Vaccine Antigens

Product:Lactovac® suspension for injection

Product index:Lactovac

Cattle - milk:Zero days

Cattle - meat:Zero days


A suspension for injection, each 5 ml contains:

Inactivated bovine rotavirus, strain 1005/78

≥ 1 RPU*
Inactivated bovine rotavirus, strain Holland ≥ 1 RPU*
Inactivated bovine coronavirus, strain 800 ≥ 1 RPU*
Inactivated E. coli K99/F41, strain S1091/83 ≥ 1 RPU*
Each dose also contains aluminium hydroxide (60 mg) and Quil A (Quillaja saponaria, saponin extract) (1 mg) as adjuvants and thiomersal (0.05 mg) as preservative.

* Relative potency unit; 1 RPU = antibody response in rabbit potency test not significantly lower than that obtained with a reference batch shown efficacious in cattle.


For the active immunisation of pregnant cows and heifers in order to confer passive protection to their calves (via colostrum) to reduce the severity and duration of neonatal diarrhoea caused by rotavirus, coronavirus and E. coli (K99/F41) infections.

Protection is conferred only while the calves are fed colostrum from vaccinated cows.

Dosage and administration


One dose of 5 ml by subcutaneous injection in the side of the neck, observing aseptic precautions.

Vaccination schedule

All cows in a herd should receive two injections of 5 ml during the later stages of pregnancy, with an interval of 4-5 weeks between doses and allowing 2-3 weeks from the time of the second dose until the predicted date of calving.


During each subsequent pregnancy previously vaccinated cows should receive a single injection of 5 ml 2-6 weeks prior to predicted calving date.

Passive immunisation

In order to attain local passive immunisation within the intestine against neonatal diarrhoea, the newborn calves must receive sufficient quality colostrum and milk from the vaccinated dams during the first 10 to 14 days of life. For calves born to beef cows this can be achieved by allowing the calf to suckle naturally. Calves born to dairy cows often do not receive sufficient colostrum if suckled naturally, so artificial feeding of colostrum (e.g. via oesophageal tube feeders) should be used.

Feeding and storage of colostrum

For optimal protection it has been shown that daily intake of colostrum is essential to the calf from birth to 2 weeks of age. All calves should be fed colostrum derived from the first milking, ideally within the first 6 hours of life. Calves should then either be left to suckle naturally for a minimum of 2 weeks or a colostrum feeding regime must be established. Any remaining quantities from the first milking and all the colostrum from the second milking of each individual dam should be pooled, aliquoted and stored deep frozen (-20ºC for a maximum of one year). Alternatively, these colostrum pools can be stored at about +4°C for about 2 weeks. Following the first suckling of colostrum from the dam by the calves, where the calves are separated from the dam, their feed must be supplemented with 500ml of pooled colostrum from their own dam each day.

Contra-indications, warnings, etc

Do not use in animals which have intercurrent infection or are in poor nutritional status.

Immunisation may very commonly result in temporary swellings at the injection site (ranging from small nodules of approximately 1 cm in diameter to swellings of 20 cm in diameter in extreme cases). Typically, these swellings completely disappear or reduce to a negligible size within 2-4 weeks after vaccination, though in individual animals very small reactions remain longer. Additionally, a transient slight rise in body temperature normally decreasing to a non-significant level within one day may commonly be expected.

The frequency of adverse reactions is defined using the following convention:

-very common (more than 1 in 10 animals treated displaying adverse reaction(s))

-common (more than 1 but less than 10 animals in 100 animals treated)

-uncommon (more than 1 but less than 10 animals in 1,000 animals treated)

-rare (more than 1 but less than 10 animals in 10,000 animals treated)

-very rare (less than 1 animal in 10,000 animals treated, including isolated reports)

Can be used during pregnancy.

No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.

Do not mix with any other veterinary medicinal product.

Withdrawal period

Zero days

User warnings

In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician. People with known hypersensitivity to any of the components of the product should administer the veterinary medicinal product with caution.

Pharmaceutical precautions

Store in a refrigerator (+2°C to +8°C). Protect from frost.

Shelf-life after first opening the immediate package: 10 hours.

Keep out of the sight and reach of children.

For animal treatment only.

Legal category

Legal category:POM-VPS

Packaging quantities

Cardboard box containing a 25 ml glass vial of 5 doses or 10 x 5 ml single dose glass vials. Not all pack sizes may be marketed.

Further information

Protection of the herd

Neonatal diarrhoea in calves is caused by pathogens which are constantly present in the herd. For this reason proper control measures require that all pregnant cows and heifers in a herd must be included in the programme of immunisation. This is the only way in which the pressure of infection can be reduced.

Herd hygiene

Neonatal diarrhoea in calves is often associated with poor hygiene. Thus, general improvements in hygiene are important to support the effect of vaccination.

Immune protection

Diarrhoeal diseases can have many causes. The vaccine induces high levels of antibody in the colostrum and milk against rotavirus and coronavirus as well as against E. coli, i.e. against the principal pathogens of neonatal diarrhoea in calves.

The feeding of pooled colostrum is recognised as a potential factor in the spread of Johne’s disease. Please discuss with your veterinary surgeon if you are concerned.


Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Marketing Authorisation Number

Vm 42058/4075

Significant changes


GTIN description:25 ml:



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ValueWeightDelivery Charge
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Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

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We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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