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Hyonate 2 x 2ml

Item Number: HYONATE

Hyonate 2 x 2ml
  • 2 x 2ml

    Estimated dispatch on Wednesday

    £ 177.95

Total: £0.00

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Description

For the treatment of lameness in horses due to non-infectious inflammation of joints.

Dosage and administration

For intravenous or intra-articular use.

The recommended dose is:

Intravenous administration
 4 ml (corresponding to 40 mg a.i)
 
Intra-articular administration
 2 ml (corresponding to 20 mg a.i)

Treatment may be repeated at weekly intervals for a total of three treatments.


Data Sheets

Hyonate 10 mg/ml Solution for Injection Species:Horses and other equidae

Therapeutic indication:Pharmaceuticals: Anti-inflammatory preparations: Injections: Others, Locomotor (including navicular and osteoarthritis)

Active ingredient:Sodium Hyaluronate

Product:Hyonate 10 mg/ml solution for injection

Product index:Hyonate

Withdrawal notes:Horse meat: zero days

Qualitative and quantitative composition

Each ml contains:

Active substance: Sodium hyaluronate 10 mg

For the full list of excipients, see below.

Pharmaceutical form

Solution for Injection. Clear, colourless liquid

Clinical particulars

Target species

Horses

Indications for use

For the treatment of lameness in horses due to non-infectious inflammation of joints

Contra-indications

None known

Special warnings for each target species

This product does not contain an antimicrobial preservative. Any solution remaining in the vial following withdrawal of the required dose should be discarded.

Special precautions for use in animals

See below under Amounts to be administered and administration route

Special precautions to be taken by the person administering the product to animals

None

Adverse reactions

In very rare cases, horses may show a transient flare reaction after intra-articular injection. This may present as a diffuse swelling lasting 24 – 48 hours resulting from irritation by the needle while in the joint space. These flares may be acute but will generally resolve without sequelae within a few days

Use during pregnancy, lactation or lay

The product may be used safely in pregnant and lactating animals.

Interactions

None known

Amounts to be administered and administration route

For intravenous or intra-articular use.

The recommended dose is:

Intravenous administration: 4 ml corresponding to 40 mg sodium hyaluronate

Intra-articular administration: 2 ml corresponding to 20 mg sodium hyaluronate

Treatment may be repeated at weekly intervals for a total of three treatments.

Strict aseptic technique should be observed when injecting Hyonate. As with any intra-articular procedure, proper injection site disinfection and animal restraint are very important.

Excess synovial fluid should be aseptically removed prior to injection. Care should be taken not to scratch the cartilage surface with the point of the needle while injecting.

For best results, the horse should be given three days stable rest after intra-articular treatment before gradually resuming normal activity.

Withdrawal periods

Meat: zero days.

Milk: Not applicable.

Pharmacological particulars

Sodium hyaluronate is a saccharide biopolymer with a key role in maintaining normal joint function. It also has anti-inflammatory properties.

ATC VetCode: QM09 AX01

Pharmacodynamic properties

Hyonate is extracted from the capsule of a selected micro-organism and purified to produce an ultra pure form of sodium hyaluronate which is essentially free of protein or nucleic acids. The solution is pyrogen free and sterile. It contains no preservative.

Hyaluronic acid forms the basis of a wide range of saccharide bioploymers (glycosaminoglycans or mucopolysaccharides) consisting of repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronic acid linked by beta 1-3 and beta 1-4 glycosidic bonds. It is a component of all mammalian connective tissue and therefore widely distributed in body tissues and intracellular fluids. Sodium hyaluronate is the naturally occurring sodium salt of hyaluronic acid. In the normal joint sodium hyaluronate is synthesised by synoviocytes. The resulting long chains form a three dimensionally cross linked network and are the crucial determinant of the properties of the synovial fluid.

The high affinity of sodium hyaluronate for water, which is enclosed rather than bound within the three dimensional structure, is responsible, in particular, for the known high viscosity of the synovial fluid. Recent studies have shown that sodium hyaluronate exerts its lubricant effect primarily on the membrane separating the synovial fluid from the soft tissue (capsule) of the joint.

Sodium hyaluronate, therefore, has various properties:

  • it improves the viscosity of the synovial fluid through its 3-dimensional structure (lubrication)
  • it assists the filtering function of the synovial membrane (regulation of composition of synovial fluid)
  • it is a constituent of hyaline cartilage
  • it plays a role in the supply of nutrients to the cartilage.
  • Sodium hyaluronate also exerts an anti-inflammatory action.

    Pharmaceutical particulars

    Excipients

    Sodium chloride

    Sodium acid phosphate

    Sodium dihydrogen phosphate monohydrate

    Sodium hydroxide

    Hydrochloric acid

    Water for Injection

    Major incompatibilities

    None known

    Shelf life

    Shelf-life of the product as packaged for sale: 3 years

    Shelf-life after first opening the container: Any solution remaining in the vial following withdrawal of the required dose should be discarded.

    Special precautions for storage

    Do not store above 25 °C. Protect from sunlight.

    Immediate packaging

    2 x 2ml of solution in a 2.5 ml clear glass vial with a grey stopper, an aluminium overseal and plastic cap.

    Disposal

    Any unused product or waste material should be disposed of in accordance with national requirements

    Marketing Authorisation Number

    Vm 08327/4272

    Significant changes

    Legal category

    Legal category:POM-V

    GTIN

    GTIN description:Hyonate 10 mg/ml Solution for Injection x 2 vials

    GTIN:3661103049302

    Delivery

    Shipping charges mainland UK zone1

    ValueWeightDelivery Charge
    Over £49.00Any WeightFREE
    Under £49.00No weight limit£4.50
    Under £49.00Under 250g£2.99

    Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

    NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

    Estimated "Usually shipped in" information is shown against most products

    Overseas orders

    Postage outside of the UK is from £4.50

    Prescription Items

    Prescription items will be sent on receipt of a valid signed and dated prescription.

    Pick up

    We offer a pickup service for orders placed over the phone.

    Please ring us on 01833 641112 for more information.

    Refrigerated Items

    Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

    Returns

    We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

    *Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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