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Hy-50 Vet 3ml

Item Number: HY50

Hy-50 Vet 3ml
  • 3ml

    Estimated dispatch on Thursday

    £ 122.15

Total: £0.00

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You are ordering a PRESCRIPTION ONLY medicine. Please do NOT continue unless you are sending us a valid prescription.

 

 


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Description

Hy-50 Vet for intra-articular treatment of lameness caused by joint dysfunction associated with non-infectious synovitis. Hyaluronic acid is a natural constituent of connective tissues in all mammals and its chemical structure is the same in all species. Vitreous humour, umbilical cord and synovial fluid are especially rich in hyaluronic acid. Hyaluronic acid is also found in the articular cartilage matrix.


Data Sheets

HY-50® Vet. 17 mg/ml Solution for Injection Species:Horses and other equidae Therapeutic indication:Pharmaceuticals: Anti-inflammatory preparations: Injections: NSAIDs

Active ingredient:Sodium Hyaluronate

Product:HY-50® Vet. 17 mg/ml Solution for Injection

Product index:HY-50 Vet. 17 mg/ml Solution for Injection

Withdrawal notes:Horse meat and offal: Zero days

Qualitative and quantitative composition

Active substance:

Sodium hyaluronate 17 mg/ml

Pharmaceutical form

Solution for injection. Clear, colourless, viscous solution.

Clinical particulars

Target species

Horse.

Indications for use

For intra-articular and intravenous treatment of lameness caused by joint dysfunction associated with non-infectious synovitis.

Contraindications

Do not use in cases of joint infection.

Special precautions for use in animals

Radiographic evaluation should be carried out in cases of acute, severe lameness to ensure that the joints are free from serious fractures.

Adverse reactions

Transient mild swelling and/or heat has been reported in treated joints (2.7%). These self-limiting local signs resolve spontaneously within 48 hours and do not negate a successful therapeutic outcome.

Use during pregnancy and lactation

Safety in pregnant and lactating mares has not been documented. Use only according to the benefit/risk assessment by the responsible veterinarian.

Amounts to be administered and administration route

Intravenous use: 3 ml intravenously repeated at weekly intervals for a total of three treatments.

For single intra-articular injection: 3 ml (51 mg) intra-articularly into medium sized and large joints. Smaller joints such as intertarsal, tarsometatarsal and interphalangeal joints can be treated with a 1.5 ml dose (25.5 mg).

More than one joint may be treated at the same time.

Excess synovial fluid should be removed whenever possible prior to injection.

Remove product from refrigerator approximately 10 minutes before performing injection. The injection should be administered under strict aseptic conditions. Ensure removal of dirt, hair, topical medicaments and soap/antiseptic residues. Intra-articular injections should not be made through overlying skin that is infected, blistered, scurfed or otherwise compromised. A sterile dressing and clean bandage should be applied after injection, as appropriate for the particular joint treated.

Single dose syringes made ready for injection shall be used immediately. Any unused portion of a syringe is to be discarded.

Withdrawal periods

Meat and offal: zero days.

Pharmacological particulars

Pharmacotherapeutic group: Sodium hyaluronate (hyaluronic acid)

ATCvet code: QM09AX01

Pharmacodynamic properties

The active substance in HY-50 Vet, sodium hyaluronate, is produced by a bacterial fermentation process. Sodium hyaluronate is the sodium salt of hyaluronic acid, a non-sulphated acid mucopolysaccharide or glycosaminoglycan of high molecular weight composed of equimolar amounts of D-glucuronic acid and N-acetylglocosamine linked together by glycosidic bonds.

Hyaluronic acid is a natural constituent of connective tissues in all mammals and its chemical structure is the same in all species. Vitreous humour, umbilical cord and synovial fluid are especially rich in hyaluronic acid. Hyaluronic acid is also found in the articular cartilage matrix.

Hyaluronic acid has biochemical activities which are distinct from its physical and rheological properties. It is an effective free radical scavenger, a potent inhibitor of leucocyte and macrophage migration and aggregation, and enhances healing of connective tissue.

Intra-articularly administered sodium hyaluronate alleviates aseptic joint inflammation and enhances joint function. The mechanism of action involved in the beneficial effects of sodium hyaluronate is not fully understood.

Pharmacokinetic properties

Studies with radiolabelled hyaluronic acid in rabbit and sheep indicate that after intra-articular injection, hyaluronic acid is cleared from the joint within 4-5 days. Uptake is primarily via the lymphatics. Hyaluronate is metabolised in the liver.

Pharmacokinetic properties of intravenously administered sodium hyaluronate have not been studied.

Pharmaceutical particulars

Incompatibilities

Do not mix with any other product.

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years

Single-dose syringes made ready for injection shall be used immediately. Any unused portion of a syringe is to be discarded.

Special precautions for storage

Store in a refrigerator (2°C-8°C). Do not freeze.

Immediate packaging

Pre-loaded 3 ml single-dose glass syringes. Each syringe is packaged in an individual heat-sealed tray and carton. Available in single cartons or boxes containing 12 cartons. Not all pack sizes may be marketed.

Disposal

Any unused product or waste material should be disposed of in accordance with national requirements.

Marketing Authorisation Holder (if different from distributor)

Dechra Limited, Snaygill Industrial Estate, Keighley Road, Skipton, North Yorkshire, BD23 2RW, United Kingdom.

Marketing Authorisation Number

Vm 10434/4078

Significant changes

Date of the first authorisation or date of renewal

12 June 1998

Date of revision of the text

March 2016

Any other information

For animal treatment only. To be supplied only on veterinary prescription. Keep out of the sight and reach of children.

Legal category

Legal category:POM-V

GTIN

GTIN description:HY-50 Vet. 17 mg/ml Solution for Injection:

GTIN:05701170328752

Delivery

Shipping charges mainland UK zone1

ValueWeightDelivery Charge
Over £49.00Any WeightFREE
Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

Returns

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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