Item Number: HY50
Hy-50 Vet for intra-articular treatment of lameness caused by joint dysfunction associated with non-infectious synovitis. Hyaluronic acid is a natural constituent of connective tissues in all mammals and its chemical structure is the same in all species. Vitreous humour, umbilical cord and synovial fluid are especially rich in hyaluronic acid. Hyaluronic acid is also found in the articular cartilage matrix.
|HY-50® Vet. 17 mg/ml Solution for Injection Species:Horses and other equidae Therapeutic indication:Pharmaceuticals: Anti-inflammatory preparations: Injections: NSAIDs |
Active ingredient:Sodium Hyaluronate
Product:HY-50® Vet. 17 mg/ml Solution for Injection
Product index:HY-50 Vet. 17 mg/ml Solution for Injection
Withdrawal notes:Horse meat and offal: Zero days
Qualitative and quantitative composition
Sodium hyaluronate 17 mg/ml
Solution for injection. Clear, colourless, viscous solution.
Indications for use
For intra-articular and intravenous treatment of lameness caused by joint dysfunction associated with non-infectious synovitis.
Do not use in cases of joint infection.
Special precautions for use in animals
Radiographic evaluation should be carried out in cases of acute, severe lameness to ensure that the joints are free from serious fractures.
Transient mild swelling and/or heat has been reported in treated joints (2.7%). These self-limiting local signs resolve spontaneously within 48 hours and do not negate a successful therapeutic outcome.
Use during pregnancy and lactation
Safety in pregnant and lactating mares has not been documented. Use only according to the benefit/risk assessment by the responsible veterinarian.
Amounts to be administered and administration route
Intravenous use: 3 ml intravenously repeated at weekly intervals for a total of three treatments.
For single intra-articular injection: 3 ml (51 mg) intra-articularly into medium sized and large joints. Smaller joints such as intertarsal, tarsometatarsal and interphalangeal joints can be treated with a 1.5 ml dose (25.5 mg).
More than one joint may be treated at the same time.
Excess synovial fluid should be removed whenever possible prior to injection.
Remove product from refrigerator approximately 10 minutes before performing injection. The injection should be administered under strict aseptic conditions. Ensure removal of dirt, hair, topical medicaments and soap/antiseptic residues. Intra-articular injections should not be made through overlying skin that is infected, blistered, scurfed or otherwise compromised. A sterile dressing and clean bandage should be applied after injection, as appropriate for the particular joint treated.
Single dose syringes made ready for injection shall be used immediately. Any unused portion of a syringe is to be discarded.
Meat and offal: zero days.
Pharmacotherapeutic group: Sodium hyaluronate (hyaluronic acid)
ATCvet code: QM09AX01
The active substance in HY-50 Vet, sodium hyaluronate, is produced by a bacterial fermentation process. Sodium hyaluronate is the sodium salt of hyaluronic acid, a non-sulphated acid mucopolysaccharide or glycosaminoglycan of high molecular weight composed of equimolar amounts of D-glucuronic acid and N-acetylglocosamine linked together by glycosidic bonds.
Hyaluronic acid is a natural constituent of connective tissues in all mammals and its chemical structure is the same in all species. Vitreous humour, umbilical cord and synovial fluid are especially rich in hyaluronic acid. Hyaluronic acid is also found in the articular cartilage matrix.
Hyaluronic acid has biochemical activities which are distinct from its physical and rheological properties. It is an effective free radical scavenger, a potent inhibitor of leucocyte and macrophage migration and aggregation, and enhances healing of connective tissue.
Intra-articularly administered sodium hyaluronate alleviates aseptic joint inflammation and enhances joint function. The mechanism of action involved in the beneficial effects of sodium hyaluronate is not fully understood.
Studies with radiolabelled hyaluronic acid in rabbit and sheep indicate that after intra-articular injection, hyaluronic acid is cleared from the joint within 4-5 days. Uptake is primarily via the lymphatics. Hyaluronate is metabolised in the liver.
Pharmacokinetic properties of intravenously administered sodium hyaluronate have not been studied.
Do not mix with any other product.
Shelf life of the veterinary medicinal product as packaged for sale: 3 years
Single-dose syringes made ready for injection shall be used immediately. Any unused portion of a syringe is to be discarded.
Special precautions for storage
Store in a refrigerator (2°C-8°C). Do not freeze.
Pre-loaded 3 ml single-dose glass syringes. Each syringe is packaged in an individual heat-sealed tray and carton. Available in single cartons or boxes containing 12 cartons. Not all pack sizes may be marketed.
Any unused product or waste material should be disposed of in accordance with national requirements.
Marketing Authorisation Holder (if different from distributor)
Dechra Limited, Snaygill Industrial Estate, Keighley Road, Skipton, North Yorkshire, BD23 2RW, United Kingdom.
Marketing Authorisation Number
Date of the first authorisation or date of renewal
12 June 1998
Date of revision of the text
Any other information
For animal treatment only. To be supplied only on veterinary prescription. Keep out of the sight and reach of children.
GTIN description:HY-50 Vet. 17 mg/ml Solution for Injection:
Shipping charges mainland UK zone1
|Over £49.00||Any Weight||FREE|
|Under £49.00||No weight limit||£4.50|
|Under £49.00||Under 250g||£2.99|
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