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Hexasol LA Solution for Injection

Item Number: HEXASOLLA

Hexasol LA Solution for Injection

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  • 100ml

    Estimated dispatch on Monday

    £ 49.79

  • 250ml

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    £ 109.69

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You are ordering a PRESCRIPTION ONLY medicine. Please do NOT continue unless you are sending us a valid prescription.



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Hexasol LA Solution for Injection is indicated for the treatment of acute respiratory disease caused by oxytetracycline sensitiveMannheimia (Pasteurella) haemolytica and Pasteurella multocida where an anti-inflammatory and anti-pyretic effect is required.

Hexasol should only be used after sensitivity testing of the isolated pathogens involved.

Do not use in cases of known resistance to tetracyclines.

Data Sheets

Hexasol LA Solution for Injection for Cattle Species:Cattle

Therapeutic indication:Pharmaceuticals: Anti-inflammatory preparations: Injections: Others

Active ingredient:Flunixin Meglumine, Oxytetracycline

Product:Hexasol LA Solution for Injection for Cattle

Product index:Hexasol LA

Cattle - milk:See notes

Cattle - meat:35 days

Withdrawal notes:Not for use in cattle producing milk for human consumption

Qualitative and quantitative composition

Active substance:

Oxytetracycline (as dihydrate) 30% w/v [300 mg/ml]
Flunixin (as flunixin meglumine) 2.0% w/v [20 mg/ml]
Sodium Formaldehyde Sulphoxylate 0.4 % w/v
For a full list of excipients, see section Pharmaceutical Particulars
Pharmaceutical form

Solution for injection.

A clear dark amber solution.

Clinical particulars

Target species


Indications for use, specifying the target species

Specifically formulated to provide initial anti-inflammatory for 24-36 hours and sustained anti-bacterial activity for 5-6 days following a single administration.

Indicated primarily for the treatment of bovine respiratory disease associated with Mannheimia haemolytica where an anti-inflammatory and anti-pyretic effect is required.

In addition, a wide range of organisms are known to be sensitive in vitro to oxytetracycline, including Pasteurella spp, Arcanobacterium pyogenes, Staphylococcus aureus and certain mycoplasmas. The product may therefore be of use in the treatment of disease in cattle caused by such organisms where an anti-inflammatory and antipyretic effect is required.


Use is contraindicated in animals suffering from cardiac, hepatic or renal disease, where there is a possibility of gastrointestinal ulceration or bleeding or where there is hypersensitivity to the product.

Avoid use in dehydrated, hypovolaemic or hypotensive animals as there is a potential risk of increased renal toxicity.

Do not administer other NSAIDs concurrently, or within 24 hours of each other.

Concurrent use of potentially nephrotoxic drugs should be avoided.

Do not exceed the stated dose or duration of treatment.

Special Warnings for Each Target Species

None known.

Special Precautions for Use

Special Precautions for use in animals:

Avoid intra-arterial injection.

Use in any animals less than 6 weeks of age or in aged animals may involve additional risk. If such use cannot be avoided, animals may require a reduced dosage and careful clinical management.

It is preferable that prostaglandin inhibiting drugs are not administered to animals undergoing general anaesthesia until fully recovered.

Special precautions to be taken by the person administering the product to the animals:

Avoid eye contact and direct contact with skin.

To avoid possible sensitisation reactions, avoid contact with skin. Gloves should be worn during application.

Wash hands after use.

In the case of accidental contact with eyes, rinse immediately with plenty of water and seek medical advice.

The product may cause reactions in sensitive individuals. If you have known hypersensitivity for non-steroidal anti-inflammatory products, do not handle the product. Reactions may be serious.

Avoid accidental self-injection.

Adverse reactions (frequency and seriousness)

The use of tetracyclines during the period of tooth and bone development, including late pregnancy, may lead to discolouration.

Although the product is well tolerated, occasionally a local reaction of a transient nature may be observed.

Hypersensitivity reactions (collapse) may occur very rarely. Such reactions may evolve to a more severe condition (anaphylaxis), which may be life-threatening.

The frequency of adverse reactions is defined using the following convention:

- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).

Use during pregnancy, lactation or lay

The use of tetracyclines during the period of tooth and bone development, including late pregnancy, may lead to discolouration.

Safety studies have not been conducted in pregnant animals.

Interactions with other medicinal products and other forms of interaction

Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs which can lead to toxic effects.

Concurrent administration of potentially nephrotoxic drugs should be avoided.

Amount to be administered and administration route

Indicated for deep intramuscular administration to cattle. The recommended dosage is 1 ml per 10 kg bodyweight (equivalent to 2 mg/kg flunixin and 30 mg/kg oxytetracycline) on a single occasion.

Maximum volume per injection site: 15ml. If concurrent treatment is administered use a separate injection site.

Additional therapy with an NSAID may be administered after 24 hours if required.

Avoid the introduction of contamination.

Overdose (symptoms, emergency procedures, antidotes) (if necessary)

Symptomatic therapy as necessary. Maintain adequate hydration.

Withdrawal periods

Animals must not be slaughtered for human consumption during treatment.

Cattle may be slaughtered for human consumption only after 35 days from the last treatment.

Not for use in cattle producing milk for human consumption.

Pharmacological particulars

Pharmacotherapeutic group: Antibacterial, anti-inflammatory

ATCvet Code: QJ01AA56

Pharmacodynamic properties

The tetracyclines are a family of broad-spectrum bacteriostatic antibiotics which inhibit protein synthesis in susceptible microorganisms. A wide range of organisms are known to be sensitive in vitro to oxytetracycline, including Pasteurella spp, Arcanobacterium pyogenes, Staphylococcus aureus and certain mycoplasmas.

After oxytetracycline diffuses through the outer bacterial cell membrane, an active carrier mediated process transports the drugs through the inner cytoplasmic membrane. Inside the cell, oxytetracycline binds irreversibly to receptors on the 30S sub-unit of the bacterial ribosome where it interferes with the binding of the aminoacyl-transfer RNA to the acceptor site on the messenger RNA ribosome complex. This effectively prevents the addition of amino acids to the elongating peptide chain, inhibiting protein synthesis.

Flunixin meglumine is a relatively potent non-narcotic, non-steroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties.

Flunixin meglumine acts as a reversible inhibitor of cyclo-oxygenase, an important enzyme in the arachidonic acid cascade pathway which is responsible for converting arachidonic acid to cyclic endoperoxides. Consequently, synthesis of eicosanoids, important mediators of the inflammatory process involved in central pyresis, pain perception and tissue inflammation, is inhibited. Through its effects on the arachidonic acid cascade, flunixin also inhibits the production of thromboxane, a potent platelet pro-aggregator and vasoconstrictor which is released during blood clotting. Flunixin exerts its antipyretic effect by inhibiting prostaglandin E2 synthesis in the hypothalamus. By inhibiting the arachidonic acid cascade pathway, flunixin also produces an anti-endotoxic effect by suppressing eicosanoid formation and therefore preventing their involvement in endotoxin associated disease states.

Pharmaceutical particulars

List of excipients

  • Sodium Formaldehyde Sulphoxylate
  • Magnesium Oxide, Light
  • Glycerol Formal
  • Polyethylene Glycol 200
  • Monoethanolamine
  • Water for Injections
  • Incompatibilities

    None Known.


    Shelf life of the veterinary medicinal product as packaged for sale: 2 years

    Shelf life after first opening the immediate packaging: 28 days.

    Special precautions for storage

    Store upright only.

    Keep the container in the outer carton.

    Do not store above 25°C.

    Following withdrawal of the first dose, the product should be used within 28 days. Discard unused material.

    Nature and composition of immediate packaging

    Supplied in 50 ml, 100 ml, 250 ml, and 500 ml Type I, amber glass vials, sealed with bromobutyl rubber bungs and aluminium caps. The 50 ml and 100 ml pack sizes are contained within a cardboard carton while the 250 ml and 500 ml pack sizes are contained within a high density polyethylene bottle protector.

    Not all pack sizes may be marketed.

    Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products, if appropriate

    Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

    Marketing Authorisation Holder (if different from distributor)

    Norbrook Laboratories Limited, Station Works, Camlough Road, Newry, Co. Down, BT35 6JP Northern Ireland

    Marketing Authorisation Number

    Vm 02000/4152

    Significant changes

    Date of the first authorisation or date of renewal

    3rd July 2000

    Date of revision of the text

    September 2020

    Any other information


    Legal category

    Legal category:POM-V


    GTIN description:Hexasol LA Injection: 250ml


    GTIN description:Hexasol LA Injection: 100ml



    Shipping charges mainland UK zone1

    ValueWeightDelivery Charge
    Over £49.00Any WeightFREE
    Under £49.00No weight limit£4.50
    Under £49.00Under 250g£2.99

    Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

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    Prescription Items

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    We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

    *Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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