Item Number: EQUIBACTIN
Treatment of infections in horses caused by bacteria sensitive to the combination of trimethoprim and sulfadiazine, particularly:
Respiratory tract infections associated with Streptococcus spp. and Staphylococcus aureus;
Gastrointestinal infections associated with E. coli;
Urogenital infections associated with beta-hemolytic streptococci;
Wound infections and open or drained abscesses associated with Streptococcus spp. and Staphylococcus aureus.
| Equibactin® Vet. (333 mg/g + 67 mg/g) Oral Paste for Horses Species:Horses and other equidae Therapeutic indication:Pharmaceuticals: Antimicrobials: Oral preparations: Others Active ingredient:Sulfadiazine (Sulphadiazine), Trimethoprim Product:Equibactin® Vet. (333 mg/g + 67 mg/g) Oral Paste for Horses Product index:Equibactin Vet. (333 mg/g + 67 mg/g) Oral Paste for Horses Withdrawal notes:Meat and offal: 14 days. Not permitted for use in mares producing milk for human consumption. Qualitative and quantitative composition Each gram contains : Active substances: Trimethoprim 66.7 mg Sulfadiazine 333.3 mg Excipient(s): Chlorocresol 2.0 mg Pharmaceutical form Oral paste. White to almost white suspension. Clinical particulars Target species Horses Indications for use Treatment of infections in horses caused by bacteria sensitive to the combination of trimethoprim and sulfadiazine, particularly: Respiratory tract infections associated with Streptococcus spp. and Staphylococcus aureus; Gastrointestinal infections associated with E. coli; Urogenital infections associated with beta-hemolytic streptococci; Wound infections and open or drained abscesses associated with Streptococcus spp. and Staphylococcus aureus. Contraindications Do not use in horses known to be hypersensitive to sulfonamides, with serious hepatic or renal insufficiency nor with blood dyscrasias, Do not use this product to treat abscesses without proper drainage. Do not use in case resistance to sulphonamides occurs. Special precautions for use in animals During treatment with the product animals must have free and easy access to drinking water. Do not use the same syringe in more than one animal. Use of the product should be based on susceptibility testing and take into account official and local antimicrobial policies. Use of the product deviating from the instructions given in this datasheet may increase the prevalence of bacteria resistant to the combination of Sulfadiazine and Trimethoprim, and may decrease the effectiveness of treatment with sulphonamides and/or trimethoprim due to the potential for cross-resistance. Special precautions to be taken by the person administering the veterinary medicinal product to animals People with known hypersensitivity to sulfonamides should avoid contact with the veterinary medicinal product. In case of reaction of hypersensitivity after exposure (such as skin rash), seek medical advice and show the package leaflet or the label to the physician. In case of severe reactions (swelling of the face, lips or eyes), seek prompt medical attention and take the package leaflet with you. Adverse reactions Decrease or loss of appetite can occur in treated animals. Hematuria, crystalluria, tubular obstruction have been observed. Loose faeces and diarrhoea may develop during treatment with the product. If such effects appear, discontinue treatment immediately and institute appropriate symptomatic measures. Use during pregnancy and lactation Laboratory studies in rats and mice have shown evidence of teratogenic effects. The safety of the product has not been established during pregnancy. Use only according to the benefit/risk assessment by the responsible veterinarian. Interactions Potentiated sulfonamides used in conjunction with detomidine are known to be able to cause fatal arrhythmias in the horse. Amounts to be administered and administration route Administration route: Oral use. Posology: 5 mg trimethoprim and 25 mg sulfadiazine per kg body weight per day to a maximum of 5 days. One syringe is intended for 600 kg body weight and each syringe is subdivided into 12 markings. The equivalent of one marking is sufficient to treat 50 kg of body weight and the minimum body weight for treatment is 50 kg. Directions for use To ensure a correct dosage body weight should be determined as accurately as possible to avoid underdosing. The calculated dose is provided by adjusting the ring on the plunger according to the body weight of the horse. The paste is administered orally by inserting the nozzle of the syringe through the interdental space and depositing the required amount of paste on the back of the tongue. The animal's mouth should be free of any food. Immediately after administration, elevate the head of the horse for a few seconds to ensure the dose is swallowed. Withdrawal periods Meat and offal: 14 days Not permitted for use in mares producing milk for human consumption. Pharmacological particulars Pharmacotherapeutic group: Antibacterials for systemic use, Sulfonamides and Trimethoprim. ATCvet code: QJ01EW10 Pharmacodynamic properties Both active substances produce a sequential double blockade of bacterial synthesis of folic acid. This results in a synergistic and bactericidal action inhibiting sequential steps in the synthesis of purines, which are required for DNA synthesis. The combination has a broad action against many Gram-positive and Gram-negative bacteria such as staphylococci, streptococci and E.coli. MIC-breakpoints mg/l for susceptible organisms (EUCAST v. 3.1, February 2013):
Pharmacokinetic properties After a single oral administration of 5 mg trimethoprim and 25 mg sulfadiazine per kg body weight to horses, the following parameters (mean ± sd) were observed:
Excretion of both actives is chiefly by the kidneys, by both glomerular filtration, and tubular secretion. Urine concentrations of both trimethoprim and sulfadiazine are several fold higher than blood concentrations. Neither trimethoprim nor sulfadiazine interferes with the excretion pattern of the other. Pharmaceutical particulars Incompatibilities In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products. Shelf life Shelf-life of the veterinary medicinal product as packaged for sale: 3 years. Shelf-life after first opening the immediate packaging: 8 weeks. Special precautions for storage Do not refrigerate or freeze. Immediate packaging 1 or 5 pre-filled multi-dose (Low Density) polyethylene syringes with adjustable screw ring closed with a (Low Density) polyethylene cap, packed in a cardboard box. Each syringe contains 45 g paste. Not all pack sizes may be marketed. Disposal Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements. Marketing Authorisation Holder (if different from distributor) Le Vet Beheer BV, Wilgenweg 7, 3421 TV Oudewater, The Netherlands. Marketing Authorisation Number Vm 19994/4004 Significant changes Date of the first authorisation or date of renewal 7 July 2008 Date of revision of the text October 2015 Any other information For animal treatment only. To be supplied only on veterinary prescription. Keep out of the sight and reach of children. Legal category Legal category:POM-V |
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| Under £49.00 | Under 250g | £2.99 |
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