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Enrobactin 25 mg/ml concentrate for oral solution


Enrobactin 25 mg/ml concentrate for oral solution
  • 10ml

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    £ 10.09

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Target species
Pet rabbits, rodents, ornamental birds and reptiles.
Indications for use, specifying the target species
Pet rabbits
Treatment of infections of the digestive and respiratory tracts caused by enrofloxacin susceptible strains of: Escherichia coli, Pasteurella multocida and Staphylococcus spp.
Treatment of skin and wound infections caused by enrofloxacin susceptible strains of Staphylococcus aureus.
Rodents, reptiles and ornamental birds
Treatment of infections of the digestive and respiratory tracts where clinical experience, if possible, supported by susceptibility testing of the causal organism, indicates enrofloxacin as the substance of choice.
Do not use in case of known hypersensitivity to fluoroquinolones or to any of the excipients.
Do not use in animals that are epileptic or suffer from seizures since enrofloxacin may cause CNS stimulation.
Do not use in animals producing food for human consumption.
Special warnings for each target species
Special precautions for use
Special precautions for use in animals
Official and local antimicrobial policies should be taken into account when the product is used. Fluoroquinolones should be reserved for the treatment of clinical conditions which have responded poorly, or are expected to respond poorly, to other classes of antimicrobials. Whenever possible, fluoroquinolones should only be used based on susceptibility testing.
Use of the product deviating from instructions given in the SPC may increase the prevalence of bacteria resistant to fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due to the potential for cross resistance.
Special caution should be taken when using enrofloxacin in animals with impaired renal function.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
People with known hypersensitivity to fluoroquinolones should avoid any contact with the product.
Personal protective equipment consisting of impermeable gloves should be worn when handling the veterinary medicinal product.
Avoid skin and eye contact. Wash any splashes from skin or eyes immediately with water.
Wash hands after use. Do not eat, drink or smoke whilst handling the product.
Adverse reactions (frequency and seriousness)
Digestive tract disorders (e.g. diarrhoea) may occur in very rare cases. These signs are generally mild and transient.
During the period of rapid growth, enrofloxacin may affect articular cartilage.
Use during pregnancy, lactation or lay
Pet rabbits and rodents
Laboratory studies in rats and rabbits have not produced any evidence of teratogenic effects but have shown evidence of foetotoxic effects at maternotoxic doses. The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Use only accordingly to the benefit/risk assessment by the responsible veterinarian.
Birds and reptiles
The safety of the veterinary medicinal product has not been established during lay, although detrimental effects on developing eggs of avian scavengers have been reported when these birds ingest livestock meat from animals previously administered fluoroquinolones. Use only accordingly to the benefit-risk assessment by the responsible veterinarian.
Interaction with other medicinal products and other forms of interaction
Do not use enrofloxacin concomitantly with antimicrobial substances acting antagonistically to quinolones (e.g. macrolides, tetracyclines or phenicols).
Do not use concurrently with theophylline as the elimination of theophylline may be delayed.
The simultaneous application of substances containing aluminium or magnesium can impair the absorption of enrofloxacin
Amounts to be administered and administration route
Instructions for use
For administration by oral gavage.
The undiluted veterinary medicinal product is strongly alkaline and, therefore, to avoid caustic effects, it is essential to dilute the product with at least 4 parts water prior to administration. In the case of smaller animals (weighing less than 500 g), it may be appropriate to dilute 0.1 ml of the neat product with greater than 4 parts water and administer a proportion of the total volume.
10 ml bottle: A 1 ml syringe is provided with the 10 ml bottle for withdrawal of small volumes of the product and to facilitate dilution prior to administration. This syringe has dosage graduations of 0.01 and 0.1 ml. The lowest volume that has been demonstrated to be accurate is 0.1 ml. Therefore, for accuracy of dosing, it is recommended to draw up a minimum of 0.1 ml of product.
The diluted solution should be mixed thoroughly prior to administration.
The dilution should be made on a twice-daily basis immediately prior to provision, preferably in a glass container. Any unused solution should be disposed of immediately after use.
After extracting and expressing the amount of product required the syringes should be washed with lukewarm water to remove any remaining product. The syringe can subsequently be used to prepare another solution or be opened, emptied and left to dry.
Owing to physiological and pharmacokinetic differences between the wide range of species for which this product is indicated, the dose rates below are for guidance only. Depending upon the species of animal and the infection to be treated, alternative doses may be appropriate using an evidence-based approach. However, any change in dosing regimen should be based on a benefit:risk assessment by the responsible veterinarian, as tolerance at higher doses has not been investigated.
To avoid inhalation of the medication, care should be taken with restraint of the animal and administration of the product.
Rodents and pet rabbits
5 mg enrofloxacin per kg bodyweight (0.2 ml per kg bodyweight), twice daily for 7 days.
5 mg enrofloxacin per kg bodyweight (0.2 ml per kg bodyweight), at 24-48 hour intervals for 6 days.
Reptiles are ectothermic, relying on external heat sources to maintain their body temperature at the optimum level for correct function of all body systems. Metabolism of substances and activity of the immune system are, thus, critically dependant on the body temperature. Therefore, the veterinarian must be aware of correct temperature requirements of the respective reptile species and the hydration status of the individual patient. Furthermore, it has to be considered that large differences exist in the pharmacokinetic behaviour of enrofloxacin among different species, which additionally will influence the decision about the correct dosage of the veterinary medicinal product. Therefore, the recommendations made here can only be used as a starting point for individual dose setting.
Ornamental birds
10 mg enrofloxacin per kg bodyweight (0.4 ml per kg bodyweight), twice daily 7 days.
Overdose (symptoms, emergency procedures, antidotes), if necessary
In cases of accidental overdose digestive tract disorders (e.g. vomiting, diarrhoea) and neurological disorders may occur.
Withdrawal period
Do not use in animals producing food intended for human consumption.
Pharmacological particulars
Pharmacodynamic properties
Mode of action: Two enzymes essential in DNA replication and transcription, DNA gyrase and topoisomerase IV, have been identified as the molecular targets of fluoroquinolones. Target inhibition is caused by non-covalent binding of fluoroquinolone molecules to these enzymes. Replication forks and translational complexes cannot proceed beyond such enzyme-DNA-fluoroquinolone complexes, and inhibition of DNA and mRNA synthesis triggers events resulting in a rapid, drug concentration-dependent killing of pathogenic bacteria. The mode of action of enrofloxacin is bactericidal and bactericidal activity is concentration dependent.
Antibacterial spectrum: Enrofloxacin is active against many Gram-negative bacteria such as Escherichia coli, Klebsiella spp., Actinobacillus pleuropneumoniae, Pasteurella spp. (e.g. Pasteurella multocida), Bordetella spp., Proteus spp., Pseudomonas spp., against Gram-positive bacteria such as Staphylococcus spp. (e.g. Staphylococcus aureus) and against Mycoplasma spp. at the recommended therapeutic doses.
Types and mechanisms of resistance: Resistance to fluoroquinolones has been reported to arise from five sources, (i) point mutations in the genes encoding for DNA gyrase and/or topoisomerase IV leading to alterations of the respective enzyme, (ii) alterations of drug permeability in Gram-negative bacteria, (iii) efflux mechanisms, (iv) plasmid mediated resistance and (v) gyrase protecting proteins. All mechanisms lead to a reduced susceptibility of the bacteria to fluoroquinolones. Cross-resistance within the fluoroquinolone class of antimicrobials is common.
Pharmacokinetic particulars
The pharmacokinetics of enrofloxacin are such that both oral and parenteral administration leads to similar serum levels. Enrofloxacin possesses a high distribution volume. Tissue levels 2-3 times higher than found in the serum have been demonstrated in laboratory animals and target species. Organs in which high levels can be expected are the lungs, liver, kidney, skin, bone and lymphatic system. Enrofloxacin also distributes into the cerebrospinal fluid, the aqueous humour and the foetus in pregnant animals.
Pharmaceutical particulars
List of excipients
Benzyl alcohol (E-1519)
Potassium hydroxide (for pH adjustment)
Caramel aroma
Water, purified
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.
Shelf life
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
Shelf life after first opening the immediate packaging: 28 days.
Shelf life after dilution according to directions: Use immediately
Special precautions for storage
Keep the bottle tightly closed. Any remaining diluted solution should be discarded immediately after use.
Nature and composition of immediate packaging
10 ml, 30 ml, and 50 ml amber type III glass bottles closed with tamper-evident HDPE/LDPE screw caps with ring and colourless LDPE syringe insert in a carton box containing 10 ml, 30 ml and 50 ml respectively. A 1 ml dosing syringe is supplied with each 10 ml bottle, a 5 ml dosing syringe is supplied with each 30 and 50 ml bottle.
Each bottle is packed in an individual carton.
Pack size:
1 x 10 ml, 10 x (1 x 10 ml).
Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.