Free UK Delivery on orders over £49

Engemycin 10% DD Injection 100ml

Item Number: ENGEMYC10

Engemycin 10% DD Injection 100ml
  • 100ml

    Estimated dispatch on Friday

    £ 15.79

Total: £0.00

Choose quantity to add to basket

You are ordering a PRESCRIPTION ONLY medicine. Please do NOT continue unless you are sending us a valid prescription.



Browse other products from the Unbranded product range



The treatment of infections caused by organisms sensitive to oxytetracycline in horses, cattle, sheep, pigs, dogs and cats.

In vitro, oxytetracycline is active against a range of both Gram-positive and Gram-negative microorganisms including: Streptococcus spp., Staphylococcus spp., Listeria monocytogenes, Mannheimia haemolytica, Haemophilus parahaemolyticus, Bordetella bronchiseptica, and against Chlamydophila abortus (formerly Chlamydia psittaci), the causative organism of enzootic abortion in sheep.

Data Sheets

Engemycin® 10% DD Solution for injection Species:Cats, Cattle, Dogs, Horses and other equidae, Pigs, Sheep

Therapeutic indication:Pharmaceuticals: Antimicrobials: Injections

Active ingredient:Oxytetracycline Hydrochloride

Product:Engemycin® 10% DD Solution for injection

Product index:Engemycin® 10% DD

Cattle - milk:6 days

Cattle - meat:35 days

Sheep - meat:14 days

Pig - meat:14 days

Qualitative and quantitative composition

Active substance per ml:

Oxytetracycline (as hydrochloride) 100 mg

Antioxidant preservative per ml:

Sodium formaldehyde sulphoxylate 5 mg

For the full list of excipients, see section “Pharmaceutical particulars”.

Pharmaceutical form

Clear, yellow, aqueous solution for injection

Clinical particulars

Target Species

Cattle, sheep, pigs, horses, dogs and cats

Indications for use

For the treatment of infections caused by organisms sensitive to oxytetracycline in horses, cattle, sheep and pigs

In vitro, oxytetracycline is active against a range of both Gram-positive and Gram-negative micro organisms including:

Streptococcus spp., Staphylococcus spp., L. monocytogenes, P. haemolytica, H. parahaemolyticus and B. bronchiseptica and against Chlamydophila abortus, the causative organism of enzootic abortion in sheep.


Not to be administered to horses during concomitant therapy with corticosteroids.

Special warnings for each target species

As with other tetracyclines, caution should be exercised in treating horses under stress.

Exercise caution in animals with hepatic or renal impairment.

Special precautions for use

Not for intravenous administration in dogs or cats.

Operator warnings

Take care to avoid accidental injection.

In case of contact with eyes or skin, wash immediately with plenty of water as irritation may occur.

Wash hands after use.

Adverse Reactions

A transient swelling may be observed following intramuscular administration in horses and subcutaneous administration in dogs.

Photodermatitis may occur after treatment if exposure to intense sunlight occurs.

Use during pregnancy or lactation

The use of tetracyclines during the period of tooth and bone development, including late pregnancy, may lead to discolouration.


It is not recommended to administer bacteriostatic and bactericidal antibiotics concurrently.

Amounts to be administered and administration route

Can be administered at either a low dose rate for a 24 hour duration of activity or at a high dose rate for prolonged duration of activity.

24 hour dosage regime:

The recommended dosage rate is 3-10 mg/kg bodyweight (depending on age and species - see table) by intramuscular or intravenous injection in large animals and by subcutaneous or intramuscular injection in small animals.

The treatment may be repeated at 24 hour intervals up to 4 times (5 treatments in all).

Intravenous injections must be given slowly over a period of at least one


Prolonged action dosage regime:

10 or 20 mg/kg bodyweight depending on age and species (see table) by intramuscular injection only, repeated once after 48-60 hours if required.

This dosage regime is not advised for use in horses, dogs or cats.


Weight kg 24 hour dosage Prolonged action
Dose mg/kg Volume ml Dose mg/kg Volume ml
Horse 500 5 25 Not recommended
Foal 100 10 10 Not recommended
Cow 500 3 15 10 50
Calf 100 8 8 20 20
Sow/boar 150 5 7.5 10 15
Pig 25 8 2 20 5
Sheep 50 8 4 20 10
Lamb 25 8 2 20 5
Dog 10 10 1 Not recommended
Cat 5 10 0.5 Not recommended
Prophylactic treatment of enzootic abortion in sheep: 20 mg/kg administered about day 95-100 of gestation. A further treatment may be given 2-3 weeks later.

Before administration, clean the area of the injection site and swab with spirit. Repeat doses should be administered at different sites, and the sites massaged well after injection.

Maximum recommended dose at any one site: 20 ml for cattle, 10 ml for sheep and pigs.


Oxytetracyline has low toxicity, but is irritant. Overdosage should be avoided, particularly in horses. No recommended treatment.

Withdrawal periods

24 hour dose

Milk Cows 6 days
Cattle 35 days
Sheep 14 days
Pigs 14 days
Prolonged action dose
Milk cows 6 days
Cattle 21 days
Sheep 14 days
Pigs 10 days
Not for use in horses intended for human consumption.

Not for use in sheep producing milk for human consumption.

Treated horses may never be slaughtered for human consumption.

The horse must have been declared as not intended for human consumption under national horse passport legislation.

Pharmacological particulars

ATC Vet Code: QJ01AA06

Pharmacotherapeutic group:

Oxytetracycline is a bacteriostatic antibiotic which has broad spectrum antibacterial activity against both gram-positive and gram-negative bacteria. After absorption it enters most tissues and body fluids, with the exception of CSF. It is excreted unchanged, mainly in urine.

Pharmacokinetics properties

From the site of injection the drug is effectively and rapidly absorbed with minimal irritation of the tissue thanks to the low viscosity of the solvent contained in the formulation, polyvinyl pyrrolidone (PVP).

Depending on the dose rate the duration of the action after a single administration is for 24 hours or prolonged to 48 – 60 hours.

After a standard dose of 3-8 mg oxytetracycline/kg BW to target animals, drug peak plasma concentrations were achieved in 1 - 4 hours and lasted to the level of 0.5 - 1.0 µg/mL, regarded as effective, in about 24 hours; by giving IM doses of 10 – 20 mg oxytetracycline/kg BW the action was prolonged and concentrations exceeding 0.5 – 1.0 µg/ml were maintained for about 48 hours.

The drug is widely distributed in the body with highest concentrations in liver, spleen, kidneys and the lungs. Oxytetracycline is moderately protein bound (about 50 %) and is excreted mainly unchanged by the renal route, with some in the faeces and milk.

Pharmaceutical particulars


Sodium formaldehyde sulphoxylate

Magnesium Oxide

Povidone K12


Water for injection

Major incompatibilities

Dilution with calcium salts is not recommended as this may lead to precipitation of crystals.


Shelf life: 2 years

Following withdrawal of the first dose, use the product within 28 days.

Special precautions for storage

Do not store above 25oC. Protect from light. Do not freeze.

Keep container in outer carton.

Immediate packaging

Vials of amber Type II (Ph Eur) glass or PET closed with halogenated butyl rubber stopper with aluminium overseal.

Multi-dose vials of 100 ml.


Any unused product or waste material should be disposed of in accordance with national requirements.

Marketing Authorisation Holder (if different from distributor)

Marketing Authorisation Number

UK: Vm 01708/4623

Significant changes

Date of the first authorisation or date of renewal

11 December 2005

Date of revision of the text

July 2020

Any other information

For animal treatment only. Keep out of the sight and reach of children.

Legal category

Legal category:POM-V


Shipping charges mainland UK zone1

ValueWeightDelivery Charge
Over £49.00Any WeightFREE
Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.


We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

Frequently Asked Questions

There have been no questions/answers for this product so far.

Ask Question

Ask a question about Engemycin 10% DD Injection 100ml