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Emeprid 1mg/ml Oral Solution for dogs and cats 125ml

Item Number: EMEPRID

Sale Emeprid 1mg/ml Oral Solution for dogs and cats 125ml

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Description

Symptomatic treatment of vomiting and reduced gastro-intestinal motility associated with gastritis, pyloric spasm, chronic nephritis and digestive intolerance to some drugs in dogs and cats.


Data Sheets

Emeprid® 1 mg/ml oral solution for dogs and cats Species:Cats, Dogs

Therapeutic indication:Pharmaceuticals: Enteric preparations

Active ingredient:Metoclopramide

Product:Emeprid® 1 mg/ml oral solution for dogs and cats

Product index:Emeprid 1 mg/ml oral solution

Qualitative and quantitative composition

Each ml contains:

Active substance:

Metoclopramide (as hydrochloride) 0.891 mg

equivalent to metoclopramide hydrochloride 1 mg

Excipients:

Methyl parahydroxybenzoate (E218) 1.3 mg

Propyl parahydroxybenzoate 0.2 mg

For the full list of excipients, see Pharmaceutical particulars.

Pharmaceutical form

Oral solution. Clear to slightly opalescent liquid, viscous, colourless to slightly amber.

Clinical particulars

Target species

Dogs and cats.

Indications for use, specifying the target species

Symptomatic treatment of vomiting and reduced gastro-intestinal motility associated with gastritis, pyloric spasm, chronic nephritis and digestive intolerance to some drugs.

Contraindications

Do not use in cases of known hypersensitivity to the active substance or to any of the excipients.

Do not use in cases of gastro-intestinal perforation or obstruction.

Do not use in the case of gastro-intestinal haemorrhage.

Special warnings for each target species

None.

Special precautions for use

Special precautions for use in animals

The dosage must be adapted in animals with renal or hepatic insufficiency (due to an increase in the risk of side effects). Avoid administration to animals with epilepsy. The dosage should be carefully observed, especially in cats and small breed dogs.

Following prolonged vomiting, consideration should be given to fluid and electrolyte replacement therapy.

In case of vomiting after intake of the oral solution, maintain the usual interval between two administrations before administering the product again.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

In case of accidental ingestion, especially by children, seek medical advice immediately and show the package leaflet or the label to the physician.

In case of accidental exposure by spillage onto the skin or eyes, wash immediately with abundant water. If adverse effects appear, seek medical advice immediately and show the package leaflet or the label to the physician.

Wash hands after administration to the animal.

Adverse reactions (frequency and seriousness)

In some very rare cases, extrapyramidal effects (agitation, ataxia, abnormal positions and/or movements, prostration, tremors and aggression, vocalisation) have been observed after treatment of dogs and cats.

These observed effects are transient and disappear when treatment is stopped.

Use during pregnancy, lactation or lay

Laboratory studies in laboratory animals have not produced any evidence of teratogenic or foetotoxic effects. However, studies on laboratory animals are limited and the safety of the active substance has not been evaluated in the target species. The use of the product during pregnancy and lactation must be made according to the benefit/risk assessment carried out by the veterinarian.

Interaction with other medicinal products and other forms of interaction

In cases of gastritis, avoid the co-administration of anticholinergic drugs (atropine) as they may counteract the effects of metoclopramide on gastrointestinal motility.

In cases of simultaneous diarrhoea, there is no contra-indication to the use of anticholinergic drugs.

Concurrent use of metoclopramide with neuroleptics derivated from phenothiazine (acepromazine) and butyrophenones increases the risk of extrapyramidal effects (see Adverse reactions).

Metoclopramide can potentiate the action of central nervous system depressants. If used concurrently, it is advised to use the lowest dosage of metoclopramide to avoid excessive sedation.

Amounts to be administered and administration route

Oral use. Administer the product directly into the mouth.

0.5 to 1 mg of metoclopramide hydrochloride per kg of body weight per day administered as either:

2.5 to 5.0 mg/10 kg (equivalent to 2.5 to 5 ml/10 kg), twice daily

or

1.7 to 3.3 mg/10 kg (equivalent to 1.7 to 3.3 ml/10 kg), three times daily.

Oral administrations can be repeated with interval of 6 hours.

Overdose (symptoms, emergency procedures, antidotes), if necessary

Most of the clinical signs reported after an overdosage are well known extrapyramidal side effects (see Adverse reactions).

In the absence of a specific antidote, it is recommended to offer a calm environment to the animal until extrapyramidal side effects disappear.

Metoclopramide being rapidly metabolised and eliminated, side effects generally disappear quickly.

Withdrawal period

Not applicable.

Pharmacological particulars

Pharmacotherapeutic group: Propulsives. ATCvet code: QA03FA01

Pharmacodynamic properties

Metoclopramide is an original orthopramide molecule.

The anti-emetic action of metoclopramide is mainly due to its antagonist activity at D2 receptors in the central nervous system, preventing nausea and vomiting triggered by most stimuli.

The prokinetic effect on the gastro-duodenal transit (increase in intensity and rhythm of stomach contractions and opening of the pylorus) is mediated by muscarinic activity, D2 receptor antagonist activity and 5-HT4 receptor agonist activity at the gastro-intestinal level.

Pharmacokinetic particulars

Metoclopramide is rapidly and almost completely absorbed from the gastrointestinal tract following oral administration.

Metoclopramide is rapidly distributed into most tissues and fluids, crosses the blood-brain barrier and enters the central nervous system.

Metoclopramide is metabolised by the liver.

The elimination of metoclopramide is rapid, 65 % of the dose being eliminated within 24 hours in the dog, primarily by the urinary route.

Pharmaceutical particulars

List of excipients

Methyl parahydroxybenzoate (E 218), Propyl parahydroxybenzoate, Hydroxyethylcellulose, Sodium cyclamate, Saccharin sodium, Citric acid, Flavouring: sweet orange, Flavouring: apricot, Purified water

Incompatibilities

In the absence of compatibilities studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.

Shelf life after first opening: 6 months.

Special precautions for storage

This veterinary medicinal product does not require any special storage conditions.

Nature and composition of immediate packaging

Nature of container:

Coloured glass vial type III.

Child-proof stopper.

Pack size:

Cardboard box containing 1 vial of 125 ml.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Marketing Authorisation Number

UK: Vm 15052/4053

Significant changes

Date of the first authorisation or date of renewal

06 December 2010

Date of revision of the text

May 2015

Any other information

Nil

Legal category

Legal category:POM-V

Delivery

Shipping charges mainland UK zone1

ValueWeightDelivery Charge
Over £49.00Any WeightFREE
Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

Returns

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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