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Duphatrim IS Injectable Solution 100ml

Item Number: DUPHATRIMI

Duphatrim IS Injectable Solution 100ml
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Description

Uses

Duphatrim IS is a broad-spectrum antibacterial indicated in the treatment of a wide range of Gram-positive and Gram-negative organisms.

The two active ingredients, trimethoprim and sulfadiazine, sequentially block bacterial and protozoal synthesis of folinic acid, thus greatly potentiating the activity obtained when either ingredient is used alone.

In vitro antibacterial activity of Duphatrim IS is extensive, including Actinobacillus spp, Actinomyces spp, Bordetella spp, Brucella spp, Corynebacterium spp, E. coli, Haemophilus spp, Klebsiella spp, Pasteurella spp, Pneumococcus spp, Proteus spp, Salmonella spp, Staphylococcus spp (including penicillin-sensitive and penicillin-resistant), Streptococcus spp.

Duphatrim IS is indicated for use in horses, cattle, pigs, dogs and cats, for the treatment of acute, subacute and chronic bacterial infections sensitive to trimethoprim/sulfadiazine therapy such as:

Bacterial infections of the respiratory tract, including rhinitis, pneumonia, bronchitis and in bacterial infections secondary to viral disease such as viral pneumonia or mycoplasma infections.

Urogenital tract infections, including cystitis, vaginitis, urethritis, nephritis and metritis.

Alimentary tract infections, including neonatal diarrhoea and salmonellosis.

Other infections, such as foul-in-the-foot, severe mastitis, bacterial agalactia of sows, infections of the eye, ear or mouth.

Dosage and administration

Cattle and pigs:

The recommended dose rate is 15mg of active ingredients per kilogram bodyweight (1ml per 16kg bodyweight) once by intramuscular or slow intravenous injection, but in severe infections it may be repeated daily until 2 days after symptoms resolve up to a maximum of 5 days.

Duphatrim IS may be administered by intravenous injection when rapid blood levels of trimethoprim and Sulfadiazine are required.

Horses:

The recommended dose rate is 15mg of active ingredients per kilogram bodyweight (1ml per 16 kg bodyweight), by slow intravenous injection.

Dogs and Cats:

The recommended dose rate is 30mg of active ingredients per kilogram bodyweight (1ml per 8kg bodyweight), by subcutaneous injection only.

The recommended site in dogs is the loose skin at the top of the neck.

A single injection may be sufficient in uncomplicated conditions, but in severe infections it may be repeated daily for up to 5 days or until 2 days after the symptoms have resolved.


Data Sheets

Duphatrim IS Injectable Solution Species:Horses and other equidae, Pigs, Cats, Cattle, Dogs

Therapeutic indication:Pharmaceuticals: Antimicrobials: Injections

Active ingredient:Sulfadiazine (Sulphadiazine), Trimethoprim

Product:Duphatrim® IS Injectable Solution

Product index:Duphatrim IS Injectable Solution

Cattle - milk:48 hours

Cattle - meat:12 days

Pig - meat:20 days

Withdrawal notes:Not for use in horses intended for human consumption

Presentation

Duphatrim IS (Injectable Solution) is a sterile, clear yellow, aqueous solution of trimethoprim and sulfadiazine for parenteral administration. Each ml contains the following active ingredients:

Trimethoprim

40 mg
Sulfadiazine 200 mg
Chlorocresol (as antimicrobial preservative) 1 mg
Sodium Formaldehyde Sulphoxylate (as antioxidant) 1 mg
Uses

Duphatrim IS is a broad-spectrum antibacterial indicated in the treatment of a wide range of Gram-positive and Gram-negative organisms.

The two active ingredients, trimethoprim and sulfadiazine, sequentially block bacterial and protozoal synthesis of folinic acid, thus greatly potentiating the activity obtained when either ingredient is used alone.

In vitro antibacterial activity of Duphatrim IS is extensive, including Actinobacillus spp, Actinomyces spp, Bordetella spp, Brucella spp, Corynebacterium spp, E. coli, Haemophilus spp, Klebsiella spp, Pasteurella spp, Pneumococcus spp, Proteus spp, Salmonella spp, Staphylococcus spp (including penicillin-sensitive and penicillin-resistant), Streptococcus spp.

Duphatrim IS is indicated for use in horses, cattle, pigs, dogs and cats, for the treatment of acute, subacute and chronic bacterial infections sensitive to trimethoprim/sulfadiazine therapy such as:

Bacterial infections of the respiratory tract, including rhinitis, pneumonia, bronchitis and in bacterial infections secondary to viral disease such as viral pneumonia or mycoplasma infections.

Urogenital tract infections, including cystitis, vaginitis, urethritis, nephritis and metritis.

Alimentary tract infections, including neonatal diarrhoea and salmonellosis.

Other infections, such as foul-in-the-foot, severe mastitis, bacterial agalactia of sows, infections of the eye, ear or mouth.

Dosage and administration

Cattle and pigs:

The recommended dose rate is 15mg of active ingredients per kilogram bodyweight (1ml per 16kg bodyweight) once by intramuscular or slow intravenous injection, but in severe infections it may be repeated daily until 2 days after symptoms resolve up to a maximum of 5 days.

Duphatrim IS may be administered by intravenous injection when rapid blood levels of trimethoprim and Sulfadiazine are required.

Horses:

The recommended dose rate is 15mg of active ingredients per kilogram bodyweight (1ml per 16 kg bodyweight), by slow intravenous injection.

Dogs and Cats:

The recommended dose rate is 30mg of active ingredients per kilogram bodyweight (1ml per 8kg bodyweight), by subcutaneous injection only.

The recommended site in dogs is the loose skin at the top of the neck.

A single injection may be sufficient in uncomplicated conditions, but in severe infections it may be repeated daily for up to 5 days or until 2 days after the symptoms have resolved.

The suggested dosage rates are:
Horse 480 kg 30 ml
Cattle 400 kg 25 ml
Pig  80 kg  5 ml
Dog  16 kg  2 ml
Cat  4 kg  0.5 ml
Contra-indications, warnings, etc

Injections should not be given by routes other than those recommended. Not to be administered

intraperitoneally.

Adequate drinking water should be available during the therapeutic effect of the product.

Do not administer to animals with known sulphonamide sensitivity, severe liver parenchymal damage, or blood dyscrasias. As with all Trimethoprim/Sulphonamide formulations the possibility of potential damage to the kidney or liver or haemapoeitic system should be considered.

Do not administer to horses exhibiting drug-induced cardiac arrhythmias. Such arrhythmias may be associated with the administration of certain anaesthetic and sedative agents. The intravenous route is contraindicated in the case of concurrent or previous administration of central nervous system depressants (e.g. anaesthetics, neuroleptics).

Anaphylactic shock has been observed on rare occasions following administration of potentiated sulphonamide preparations, mostly after intravenous injection. For intravenous administration the product should be warmed to body temperature and injected slowly over as long a period as is reasonably practical. At the first sign of intolerance the injection should be interrupted and shock treatment initiated.

The possibility of anaphylaxis should be considered and the intravenous route in the horse should only be used if therapeutically justified.

Withdrawal periods

Milk for human consumption must not be taken during treatment. Milk for human consumption may be taken from cattle after 48 hours from the last treatment.

Animals must not be slaughtered for human consumption during treatment. Cattle may be slaughtered for human consumption only after 12 days from the last treatment. Pigs may be slaughtered for human consumption only after 20 days from the last treatment.

Not to be used in horses intended for human consumption.

The horse must have been declared as not intended for human consumption in accordance with the UK's Horse Passport Legislation.

Operator Warnings

Care must be taken to avoid accidental self-injection.

Avoid direct contact with skin and eyes. In the event of accidental spillage, wash affected area with copious amounts of water, seek medical advice if irritation persists.

Wash hands after use.

Pharmaceutical precautions

Do not store above 25°C. Do not freeze. Crystallisation of the product at low temperatures can be reversed by gentle warming. Protect from light.

Following withdrawal of the first dose, use the product within 28 days. Discard unused material.

Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.

Keep out of the reach and sight of children.

For animal treatment only.

Legal category

Legal category:POM-V

Packaging quantities

Multidose vials of 100 ml.

Further information

Duphatrim IS can be safely administered to pregnant and lactating animals.

Marketing Authorisation Number

Vm 42058/4048

Delivery

Shipping charges mainland UK zone1

ValueWeightDelivery Charge
Over £49.00Any WeightFREE
Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

Returns

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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