White to off white, circular, flat faced beveled edge, uncoated tablets with inscription "AA" on one side and breakline on the other side.
4.1 Therapeutic indications
a. Management of hypertension.
b. Management of angina pectoris.
c. Management of cardiac dysrhythmias.
d. Management of myocardial infarction. Early intervention in the acute phase and long term prophylaxis after recovery from myocardial infarction
4.2 Posology and method of administration
Oral administration.
The dose must always be adjusted to individual requirements of the patients, with the lowest possible starting dosage. The following are guidelines:
Adults
Hypertension
One tablet daily. Most patients respond to 100 mg daily given orally as a single dose. Some patients, however, will respond to 50 mg given as a single daily dose. The effect will be fully established after one to two weeks. A further reduction in blood pressure may be achieved by combining Atenolol tablets with other antihypertensive agents. For example, co-administration of Atenolol tablets with a diuretic provides a highly effective and convenient antihypertensive therapy.
Angina
Most patients with angina pectoris will respond to 100 mg given orally once daily or 50 mg given twice daily. It is unlikely that additional benefit will be gained by increasing the dose.
Cardiac arrhythmias
Having controlled the dysrhythmias with intravenous atenolol a suitable maintenance dosage is 50 mg – 100 mg daily, given as single dose.
Myocardial infarction
For patients suitable for treatment with intravenous beta-blockade and presenting within 12 hours of the onset of chest pain, Atenolol 5–10 mg should be given by slow intravenous injection (1 mg/minute) followed by Atenolol 50 mg orally about 15 minutes later, provided no untoward effects have occurred from the intravenous dose. This should be followed by a further 50 mg orally 12 hours after the intravenous dose, and then 12 hours later by 100 mg orally, once daily. If bradycardia and/or hypotension requiring treatment, or any other untoward effects occur, Atenolol should be discontinued.
Older population
Dosage requirements may be reduced, especially in patients with impaired renal function.
Paediatric population
There is no paediatric experience with Atenolol and for this reason it is not recommended for use in children.
Renal failure
Since Atenolol is excreted via the kidneys, the dosage should be adjusted in cases of severe impairment of renal function.
No significant accumulation of Atenolol occurs in patients who have a creatinine clearance greater than 35 ml/min/1.73 m2 (normal range is 100–150 ml/min/1.73 m2).
For patients with a creatinine clearance of 15–35 ml/min/1.73 m2 (equivalent to serum creatinine of 300–600 micromol/litre), the oral dose should be 50 mg daily and the intravenous dose should be 10 mg once every two days.
For patients with a creatinine clearance of less than 15 ml/min/1.73 m2 (equivalent to serum creatinine of greater than 600 micromol/litre), the oral dose should be 25 mg daily or 50 mg on alternate days and the intravenous dose should be 10 mg once every four days.
Patients on haemodialysis should be given 50 mg orally after each dialysis; this should be done under hospital supervision as marked falls in blood pressure can occur.
Method of administration
For administration by the oral route.
4.3 Contraindications
• Atenolol, as with other beta-blockers, should not be used in patients with any of the following:
• Cardiogenic shock
• Uncontrolled heart failure
• Sick sinus syndrome (including sino-atrial block)
• Second-or third-degree heart block
• Untreated phaeochromocytoma
• Metabolic acidosis
• Bradycardia (< 45 bpm)
• Hypotension
• Known hypersensitivity to the active substance, or any of the excipients listed in section 6.1
• Severe peripheral arterial circulatory disturbances
Shipping charges mainland GB zone1
| Value | Weight | Delivery Charge |
| Over £49.00 | Any Weight | FREE |
| Under £49.00 | No weight limit | £4.50 |
| Under £49.00 | Under 250 grams | £3.49 |
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We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email sales@hyperdrug.co.uk to obtain a returns number.
*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.
