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Antisedan 5mg/ml 10ml

Item Number: ANTISEDAN

Antisedan 5mg/ml 10ml

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Description

Atipamezole is a selective alpha-2 adrenoceptor antagonist which is indicated for the reversal of the sedative and analgesic effects of medetomidine or dexmedetomidine in dogs and cats. It also reverses all other effects of medetomidine or dexmedetomidine, such as cardiovascular and respiratory effects.

Dosage and administration

For intramuscular injection. Atipamezole (Antisedan) is quickly absorbed and is generally administered 15–60 minutes after the medetomidine or dexmedetomidine.

-- Dogs

The optimal dose of Antisedan, in micrograms per kilogram (mcg/kg), is five times that of the previous medetomidine dose or ten times that of the previous dexmedetomidine dose. The Antisedan dose in millilitres is the same as that of medetomidine 1mg/ml solution or dexmedetomidine 0.5mg/ml solution. The Antisedan dose in millilitres is one fifth (1/5) of the dose volume of dexmedetomidine 0.1mg/ml solution.

Where medetomidine (Domitor) or dexmedetomidine (Dexdomitor) has been used, with or without butorphanol, as a premedicant to thiopentone-halothane anaesthesia in dogs, or as a premedicant to propofol anaesthesia in dogs, Antisedan may be administered in the post-operative phase to reverse the effects of medetomidine or dexmedetomidine and hasten recovery. Antisedan in the post-operative phase rapidly causes arousal to full awareness and thus radically reduces the period of possible cardiovascular depression and hypothermia.

-- Cats

The optimal dose of Antisedan, in micrograms per kilogram (mcg/kg), is two-and-a-half times that of the previous medetomidine dose or five times that of the previous dexmedetomidine dose. The Antisedan dose in millilitres is half of the dose volume of medetomidine 1mg/ml solution or dexmedetomidine 0.5mg/ml solution and one tenth (1/10) of the dose volume of dexmedetomidine 0.1mg/ml solution.

The dose of Antisedan in micrograms per kilogram (mcg/kg) should not exceed four times that of the previously administered medetomidine or eight times that of dexmedetomidine.

When cats have been anaesthetised with medetomidine (Domitor) or dexmedetomidine (Dexdomitor), with or without butorphanol, and ketamine, Antisedan may be administered to reverse the effects of medetomidine or dexmedetomidine and so speed recovery from anaesthesia.


Contra-indications, warnings, etc

Antisedan has only been administered to a limited number of pregnant dogs and cats and therefore cannot be recommended in pregnancy.

In dogs, a transient hypotensive effect has been observed during the first ten minutes post-injection.

Vomiting, panting, defaecation and muscle tremors (possibly shivering) have been reported, but these effects appear to be rare.

In dogs when a combination of butorphanol, medetomidine (Domitor) or dexmedetomidine (Dexdomitor) and ketamine has been used Antisedan should not be used.

In cats, when using low doses of Antisedan to partially reverse the effects of medetomidine or dexmedetomidine, the possibility of hypothermia (even when aroused from sedation) should be guarded against.

No harmful interactions with other agents have been encountered in clinical trials. However, concurrent use of drugs affecting the CNS is not recommended, apart from those in the data sheet.

Transient over-alertness and tachycardia may be observed after a possible overdosage. Over-alertness in the cat is best handled by minimising external stimuli.

Operator Warnings

Due to the potent pharmacological effect of Antisedan, skin contact should be avoided and impervious gloves should be worn during administration. Care should be taken to avoid accidental self-injection. If accidental self-injection occurs, seek immediate medical attention showing a copy of the product literature. Do not drive. The patient should not be left unattended. In case of accidental spillage, wash the affected area immediately with clean running water. Seek medical attention if irritation persists. In case of accidental ingestion, seek medical advice immediately.


Pharmaceutical precautions

Do not store above 25°C. Protect from light.

Following withdrawal of the first dose use the product within 28 days. Discard any unused material.

Avoid the introduction of contamination during use.

Keep out of the reach and sight of children.

For animal treatment only.

Any unused veterinary medicinal product or waste materials derived from such products should be disposed of in accordance with local requirements.


Data Sheets

ANTISEDAN: Data Sheet

Delivery

Shipping charges mainland UK zone1

ValueWeightDelivery Charge
Over £49.00Any WeightFREE
Under £49.00No weight limit£4.50
Under £49.00Under 250g£2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

Returns

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email [email protected] to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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