Ubrolexin Intramammary Suspension for lactating dairy cows.
Each intramammary syringe contains:
Cefalexin (as monohydrate)
Kanamycin (as monosulphate)
Treatment of clinical mastitis in lactating dairy cows for bacteria susceptible to the combination of cefalexin and kanamycin such as Staphylococcus aureus, Streptococcus dysgalactiae, Streptococcus uberis and Escherichia coli.
Dosage and administration
For intramammary use. Treat the infected quarter(s) twice, leaving an interval of 24 hours between treatments. Use the contents of one syringe (containing 200 mg cefalexin as monohydrate and 100,000 I.U. kanamycin as monosulphate) per quarter per treatment. Each syringe is for single use only. Before infusion, the udder should be milked out completely, the teat should be thoroughly cleaned and disinfected and care should be taken to avoid contamination of the injector nozzle.
Contra-indications, warnings, etc
Do not use in lactating dairy cows with a known hypersensitivity to cefalexin and/or kanamycin.
Do not use in non-lactating cattle.
Do not use in the case of known resistance of cefalexin and/or kanamycin.
In general, combination with bacteriostatic antimicrobials should be avoided. In case of resistance to cefalexin, cross-resistance with other cephalosporins is likely to occur. In case of resistance to kanamycin, cross-resistance occurs between kanamycin, neomycin and paromomycin. A one way resistance with streptomycin is known.
Special precautions for use in animals:
The product should be used for treatment of clinical mastitis only.
Use of the product should be based on susceptibility testing of the bacteria isolated from the animal. If this is not possible, therapy should be based on local (regional and farm level) epidemiological information about susceptibility of the target bacteria as well as by taking into account official national antimicrobial policies. Inappropriate use of the product may increase the prevalence of bacteria resistant to cefalexin and kanamycin and may decrease the effectiveness of treatment with other cephalosporins or aminoglycosides due to the potential for cross-resistance.
Studies in laboratory animals have not produced any evidence of teratogenic effect. Field studies in dairy cows have not produced any evidence of a teratogenic, foetotoxic or maternotoxic effect. The product can be used in pregnant cows. The product is intended for use during lactation.
Special precautions for the user:
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross sensitivity to cephalosporin and vice versa. Allergic reactions to these substances may occasionally be serious.
1.Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.
2.Take all recommended precautions. Handle this product with great care to avoid exposure by accidental contact with the skin. It is recommended to wear gloves when handling or administering the product . Wash exposed skin after use.
3.If you develop symptoms following exposure, such as skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips and eyes or difficulty in breathing are more serious symptoms and require urgent medical attention.
Meat and offal: 10 days
Milk: 120 hours
Keep out of reach and sight of children. For animal treatment only. This veterinary medicinal product does not require any special precautions for storage.
Any unused veterinary medicinal product or waste material derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
Cardboard box with 10 or 20 single use intramammary syringes and 10 or 20 teat wipes (containing isopropanol 70%). Each 10 g syringe contains 12 ml intramammary suspension and consists of a barrel with plunger and sealed sterile tip, all made of low density polyethylene.
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