Quiflor 100mg/ml Solution for Injection

Quiflor 100mg/ml Solution for Injection


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Item Number: QUIFORI 
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Unit Price:

£110.89 (Incl. Vat)

Usually despatched within 24-48 hours

Quantity

NB This is a prescription only medicine
How do I buy Prescription medicines from you?

  1. Obtain a Prescription from your vet
  2. Place your order online or by phone
  3. Either fax email* or post your prescription to us.
  4. “Controlled Drugs” such as Epiphen or Tramadol can be only be dispensed ofter receipt of an original valid prescription sent by post. Controlled Drugs must be sent via tracked, signature delivery and do not qualify for free delivery.
  5. **Unless your vet has stated that the original must be sent to us.
  6. Choose your delivery method. Either Royal Mail Special Delivery which operates a next working day service, requiring a signature(Our recommended option). Or First class post which is free, but at your own risk, and is usually next working day but may take longer.
  7. Hyperdrug Pharmaceuticals Ltd, Middleton In Teesdale, Barnard Castle, County Durham, DL12 0NG.
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You are ordering items which require a prescription, Tampering with a prescription or attempting to obtain extra unauthorise supplies is a criminal offence and will have to be reported to the authorities. “Controlled Drugs” such as Epiphen or Tramadol can be only be dispensed ofter receipt of an original valid prescription sent by post. Controlled Drugs are sent via tracked, signature delivery.

  1. Place your order online or by phone
  2. Obtain a Prescription from your vet
  3. Either post the original, fax it to 01833 641032, or email it to us at [email protected]

 I have a prescription on file
 I am sending you a prescription by email
 I am sending you a prescription by fax
 I am sending you a prescription by post



Description

Quiflor 100mg/ml Solution for Injection.

Target species:
Cattle and pigs (sows).

Indications for use, specifying the target species:
Cattle
Treatment of respiratory infections caused by sensitive strains of Pasteurella multocida, Mannheimia haemolytica and Mycoplasma bovis.
Treatment of acute mastitis caused by Escherichia coli strains sensitive to marbofloxacin during the lactation period.

Sows
Treatment of Metritis Mastitis Agalactia Syndrome caused by bacterial strains sensitive to marbofloxacin.

The product should only be used based on susceptibility testing.
 
Contraindications:
Do not administer in animals with known hypersensitivity to marbofloxacin or any other quinolone or to any of the excipients.
Do not use in cases where the pathogen involved is resistant to other fluoroquinolones (cross resistance).

Special warnings for each target species:
None.

Special precautions for use:
Special precautions for use in animals:
Official and local antimicrobial policies should be taken into account when the product is used. Fluoroquinolones should be reserved for the treatment of clinical conditions which have responded poorly, or are expected to respond poorly, to other classes of antimicrobials. Whenever possible, fluoroquinolones should only be used based on susceptibility testing. Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to the fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due to the potential for cross resistance.

Special precautions to be taken by the person administering the veterinary medicinal product to animals:
People with known hypersensitivity to (fluoro)quinolones should avoid contact with the veterinary medicinal product.
Avoid contact of the skin and eyes with the product. In case of accidental spillage onto skin or eyes, rinse the affected area with large amounts of water.
Avoid accidental self-injection, since this can cause local irritation. In case of self-injection or ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.
Wash hands after use.

Adverse reactions (frequency and seriousness):
Administration by the intramuscular route may cause transient local reactions such as pain and swelling at the injection site and inflammatory lesions which persist at least 12 days after injection. However, in cattle, subcutaneous route was shown to be better tolerated locally than intramuscular route. Therefore, the subcutaneous route is recommended in heavy cattle.

Use during pregnancy, lactation or lay:
Studies in laboratory animals (rats, rabbits) did not show any teratogenic, embryotoxic effects or any maternal toxicity of marbofloxacin.
Safety of the product has been shown in cows during gestation and in suckling pigs and calves when used in cows and sows.
In the case of use in the cow during lactation, see paragraph 4.11. Withdrawal Periods.
May be used in pregnant and lactating cows and sows.

Interaction with other medicinal products and other forms of interaction:
None known.

Amounts to be administered and administration route:
The recommended dosage is 2mg/kg/day (1ml/50kg) in a single daily injection by intramuscular, subcutaneous or intravenous routes in cattle and by intramuscular route in pigs.

Treatment durations are 3 days in pigs and 3 to 5 days in cattle.
To ensure administration of a correct dose, body weight should be determined as accurately as possible, to avoid underdosing.

In order to reduce the risk of particulate contamination of the product, it is recommended that a draw-off needle be used to reduce the number of times the septum is punctured.

Overdose (symptoms, emergency procedures, antidotes), if necessary:
No sign of overdose has been observed after administration of 3 times the recommended dose.
Overdose may cause signs in the form of acute neurological disorders which would have to be treated symptomatically.

Withdrawal period(s):
Cattle:
Meat and offal: 6 days
Milk: 36 hours

Pigs (sows): 
Meat and offal: 4 days

PHARMACOLOGICAL PROPERTIES:
Pharmacotherapeutic group: Antibacterials for systemic use, Fluoroquinolones, ATCvet code: QJ01MA93

Pharmacodynamic properties:
Marbofloxacin is a synthetic, bactericidal antimicrobial, belonging to the fluoroquinolone group which acts by inhibition of DNA gyrase. It is effective against a wide range of Gram positive bacteria (in particular Staphylococci) and Gram negative bacteria (Escherichia coli, Salmonella typhymurium, Campylobacter jejuni, Citrobacter freundii, Enterobacter cloacae, Proteus spp., Klebsiella spp., Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Mannheimia haemolytica, Pasteurella multocida, Histophilus spp., Moraxella spp., Pseudomonas aeruginosa) as well as Mycoplasma (Mycoplasma bovis, Mycoplasma dispar, Mycoplasma hyopneumoniae).
Resistance in Streptococcus may occur.

Resistance to fluoroquinolones occurs by chromosomal mutation with three mechanisms: decrease of the bacterial wall permeability, expression of efflux pump or mutation of enzymes responsible for molecule binding.

Pharmacokinetic particulars:
After subcutaneous administration in cattle and pigs at the recommended dose of 2 mg/kg, marbofloxacin is readily absorbed and its bioavailability is close to 100%. It is weakly bound to plasma proteins (less than 10% in pigs and 30% in cattle), extensively distributed and in most tissues (liver, kidney, skin, lung, bladder, uterus, digestive tract) it achieves higher concentrations than in plasma.
In cattle, marbofloxacin is eliminated slowly in pre-ruminating calves (t1/2 ? = 5-9 h) predominantly in the active form in urine (3/4) and faeces (1/4).
In pigs, marbofloxacin is eliminated slowly (t1/2 ? = 8-10 h) predominantly in the active form in urine (2/3) and faeces (1/3).


PHARMACEUTICAL PARTICULARS
List of excipients:
Metacresol
Disodium edetate
Monothioglycerol
Gluconolactone
Water for injections

Incompatibilities:
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

Shelf life:
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.
Shelf-life after first opening the immediate packaging: 28 days.

Special precautions for storage:
Store in the original package in order to protect from light.
Do not freeze.

Nature and composition of immediate packaging:
Bottle (amber glass type II), bromobutyl rubber stopper, aluminium closure: 50 ml solution for injection, in a box.
Bottle (amber glass type II), bromobutyl rubber stopper, aluminium closure: 100 ml solution for injection, in a box.
Bottle (amber glass type II), bromobutyl rubber stopper, aluminium closure: 250 ml solution for injection, in a box.

Not all pack sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products:
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Delivery

Free shipping from Hyperdrug

Value Weight Delivery Charge*  
Over £49.00 Any Weight FREE*
Under £49.00 Under 250g £2.49
Under £49.00 No weight limit £4.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited delivery options are available.

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