Prosolvin Solution for Injection for cattle, pigs and horses.
Prosolvin is a luteolytic agent. Provided an active corpus luteum is present it will cause luteal regression which will be followed by follicle growth, oestrus and ovulation.
Prosolvin is indicated for use in cattle, pigs and horses in the following situations:
1. Oestrus control: Cows and heifers treated during the luteal phase will normally return to oestrus and ovulate 2–4 days after treatment. In mares, oestrus will normally occur within 5 days of treatment followed by ovulation 2–4 days later.
2. Oestrus synchronisation: When a group of cows at different stages in the oestrous cycle are to be synchronised, two injections of Prosolvin will be required with an interval of 10–12 days between injections. It is recommended that animals be served/ inseminated at the oestrus following treatment, i.e. at 72 hours after the second injection. If double insemination is preferred, this should take place at 72 and 96 hours after the second injection. Alternatively, Prosolvin may be used in conjunction with GnRH (see Further Information).
3. Treatment of sub-oestrus: This condition is found in lactating cows at the peak of production. Animals may have normal cyclical ovarian activity, but may not show any outward signs of oestrus. Having confirmed the presence of a corpus luteum, treatment with Prosolvin will cause luteal regression followed by oestrus in 2–4 days.
4. Induction of abortion: Prosolvin can be used to induce abortion in cattle and mares. Animals may be treated from 1 week and up to 5 months after misalliance. Following luteal regression, abortion will usually occur within 7 days. In some cases, particularly those later on in the pregnancy, a second or third treatment may be required.
5. Induction of parturition: In cattle Prosolvin may be used to initiate labour after the 270th day of pregnancy. Calving may be expected within 3 days of treatment. In pigs, Prosolvin may be used on or after the 113th day of the gestation period (see also Further Information). Parturition will normally follow within 48 hours. Prosolvin may also be used to induce parturition in the mare. Treatment must occur on or after the 330th day of pregnancy and the mare must show relaxed pelvic ligaments and a functional udder with colostrum. Following treatment parturition may be expected within a few hours.
6. Treatment of anoestrus: A persistent corpus luteum, particularly during lactation may result in an anoestral mare. Prosolvin may be used to cause luteal regression; oestrus and ovulation will then follow usually within 4–8 days of treatment.
7. Treatment of endometritis or pyometra in cows: The luteolytic effect of Prosolvin induces oestrus which will aid the expulsion of uterine discharge. A single injection of 2 ml should be given; intransigent cases may require a repeat treatment after 10–14 days or alternative therapies should be considered.
Dosage and administration
single or repeated injection of 2 ml (15 mg luprostiol).
single or repeated injection of 1 ml (7.5 mg luprostiol).
single or repeated injection of 1 ml (7.5 mg luprostiol).
single injection of 1 ml (7.5 mg luprostiol).
Prosolvin is administered by deep intramuscular injection.
Contra-indications, warnings, etc
1. This product should not be given to pregnant animals unless the intention is to produce abortion or parturition.
2. Intravenous injection is not recommended.
3. Very few adverse reactions have been seen with Prosolvin. Sweating and a slight respiratory effect have been reported in a small number of horses, but these effects were mild and transient. It is, however, possible for prostaglandins to cause diarrhoea in horses and abdominal discomfort in cattle.
Prostaglandins of the F2a type can be absorbed through the skin and may cause bronchospasm or miscarriage. Care should be taken when handling the product to AVOID SELF-INJECTION OR SKIN CONTACT.
Women of child-bearing age, asthmatics and persons with bronchial or other respiratory problems should avoid contact with, or wear disposable plastic gloves when administering, the product. Accidental spillage on the skin should be washed off immediately with soap and water.
Animals must not be slaughtered for human consumption during treatment.
Cattle and pigs may be slaughtered only after 4 days from last treatment. Milk from treated cattle may be taken for human consumption 12 hours after the last treatment.
Not to be used in horses intended for human consumption.
For animal treatment only. Keep out of the reach and sight of children.
Do not store above 25°C. Protect from light.
Following withdrawal of the first dose, use the product within 28 days. When the container is broached (opened) for the first time, use the in-use shelf life which is specified on the package insert to calculate the date on which any product remaining in the container should be discarded. This discard date should be written in the space provided on the label.
Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority
Legal category: POM-V
Multidose vials containing 10 ml and 20 ml.
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