Prilium Powder for Oral Solution for Dogs

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Prilium Powder for Oral Solution for Dogs


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Item Number: PRILIUM 
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75mg £25.25 Usually despatched within 24 hours
150mg £40.39 Usually despatched within 24 hours

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NB This is a prescription only medicine
How do I buy Prescription medicines from you?

  1. Obtain a Prescription from your vet
  2. Place your order online or by phone
  3. Either fax email* or post your prescription to us.
  4. “Controlled Drugs” such as Epiphen or Tramadol can be only be dispensed ofter receipt of an original valid prescription sent by post. Controlled Drugs must be sent via tracked, signature delivery and do not qualify for free delivery.
  5. **Unless your vet has stated that the original must be sent to us.
  6. Choose your delivery method. Either Royal Mail Special Delivery which operates a next working day service, requiring a signature(Our recommended option). Or First class post which is free, but at your own risk, and is usually next working day but may take longer.
  7. Hyperdrug Pharmaceuticals Ltd, Middleton In Teesdale, Barnard Castle, County Durham, DL12 0NG.
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You are ordering items which require a prescription, Tampering with a prescription or attempting to obtain extra unauthorise supplies is a criminal offence and will have to be reported to the authorities. “Controlled Drugs” such as Epiphen or Tramadol can be only be dispensed ofter receipt of an original valid prescription sent by post. Controlled Drugs are sent via tracked, signature delivery.

  1. Place your order online or by phone
  2. Obtain a Prescription from your vet
  3. Either post the original, fax it to 01833 641032, or email it to us at [email protected]

 I have a prescription on file
 I am sending you a prescription by email
 I am sending you a prescription by fax
 I am sending you a prescription by post



Description

Prilium Powder for Oral Solution for Dogs.

Presentation

A fine white powder for oral solution. After reconstitution, the solution is limpid and colourless.

Containing 75mg, 150 mg or 300 mg of imidapril hydrochloride.

Uses

Imidapril is a pro-drug which is hydrolysed in vivo to form an active metabolite, imidaprilat. Imidaprilat inhibits the angiotensin-converting enzyme (ACE). This enzyme catalyses the conversion of angiotensin I to angiotensin II in the blood plasma and tissues and inhibits the breakdown of bradykinin. As angiotensin II has a potent vasoconstrictive action, while bradykinin is a vasodilator, the reduced formation of angiotensin II and the inhibition of bradykinin breakdown lead to vasodilation. Imidapril reduces heart preload and afterload, and decreases blood pressure without any compensatory increase in the heart rate in dogs. It is indicated in the treatment of moderate to severe heart failure by mitral regurgitation or by dilated cardiomyopathy

Dosage and administration

The recommended dose of imidapril is 0.25 mg/kg once a day per oral route,

0.1 ml/kg of PRILIUM 75mg for dogs weighing more than 2kg (1ml/10kg)

0.05 ml/kg of PRILIUM 150 mg for dogs weighing more than 4 kg (1ml/20kg).

0.025 ml/kg of PRILIUM 300 mg for dogs weighing more than 8 kg (1ml/40kg).

The product can be administered either directly into the mouth of the animal on an empty stomach or during the meals, or on food.

Preparation of the oral solution: Remove the nipple and the stopper of the vial containing the powder and fill with tap water up to the 30ml mark which is indicated by a raised ring around the body of the bottle, place the child proof cap and screw on tightly.

Administration: Unscrew the child proof cap, introduce the graduated syringe into the applicator, turn the assembly upside down and measure the quantity to administer using the syringe graduated in kg and mls. Once the product has been administered, replace the child proof cap onto the vial and rinse the syringe with water. Store the vial in the fridge.

Contra-indications, warnings, etc

Do not use in dogs with low blood pressure.

Do not use in dogs with acute renal insufficiency.

Do not use in dogs with congenital heart disease

Do not use in dogs hypersensitive to an ACE inhibitor

Do not use in dogs with haemodynamically relevant stenoses (aortic stenosis, mitral valve stenosis, pulmonal stenosis)

Do not use in dogs with obstructive hypertrophic cardiomyopathy

Diarrhoea, hypotension and related symptoms such as fatigue, dizziness or anorexia can occur in rare cases. Vomiting can also occur in very rare cases. In such cases treatment should be discontinued until the patient's condition has returned to normal.

The use of ACE inhibitors in dogs with hypovolaemia/dehydration can lead to acute hypotension. In such cases the fluid and electrolyte balance should be restored immediately and treatment suspended until it has been stabilised. Parameters used for monitoring renal function should be checked at the beginning of the treatment and at regular time intervals thereafter.

Laboratory studies in rats and rabbits did not produce any evidence of teratogenic, embryotoxic or maternotoxic effects, or effects on reproductive performances, when imidapril was administered at the therapeutic dose.

In the absence of data, do not use in pregnant or lactating bitches or in breeding dogs.

However diuretics and a low sodium diet potentiate the effect of ACE inhibitors by activating the renin-angiotensin-aldosterone system (RAAS). Diuretics used at high doses and a low sodium diet are thus not recommended during a treatment with ACE inhibitors in order to avoid hypotension with clinical signs such as apathy, ataxia, rare syncope and kidney failure. In case of joint administration with potassium retaining diuretics, potassium must be monitored because there is a risk of hyperkaliemia

Oral doses up to 5 mg/kg of imidapril (20 times the recommended dose) have been well tolerated in healthy dogs. Hypotension may occur as a symptom of overdosage with signs of apathy and ataxia. The treatment is symptomatic.

Withdrawal periods

Not applicable

Operator warnings

In case of accidental ingestion, seek medical advice immediately and show the package insert or the label to the physician.

Wash hands after having administered the product. In case of contact with eyes, rinse immediately with plenty of water.

The vial must be closed using the child proof stopper before being stored in the fridge.

Pharmaceutical precautions

Before reconstitution: do not store above 25°C

After reconstitution: store at 2°C - 8°C (in the refrigerator) for 77days.

Any unused product or waste material should be disposed of in accordance with national requirements.

Legal category

POM-V

Packaging Quantities

Prilium 75mg: Box containing vial and a polypropylene syringe with blue graduations.

Prilium 150mg: Box containing vial and a polypropylene syringe with orange graduations.

Prilium 300mg: Box containing vial and a polypropylene syringe with mauve graduations.

Delivery

Free shipping from Hyperdrug

Value Weight Delivery Charge*  
Over £49.00 Any Weight FREE*
Under £49.00 Under 250g £2.49
Under £49.00 No weight limit £4.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited delivery options are available.

Estimated " Usually shipped in" information is shown against most products

 

Due to the large volume of parcels Royal Mail and Parcel Force handle over the Christmas period, we advise you give as much time as possible to receive your goods. Please ensure you order any essentials, such as prescription only medicines and diets, as soon as possible for UK delivery before Christmas. 
 
Last posting dates to expect goods before Christmas
Royal Mail - Wednesday 14th December
Parcel Force - Friday 16th December
Fast Track - Wednesday 21st December
 
Hyperdrug.co.uk website is open 24 hours a day, 7 days a week.
 
Office Opening hours 
Monday 19th - Friday 23rd - OPEN 8am - 5.30pm
Saturday 24th - Tuesday 27th - CLOSED
Wednesday 28th - Friday 30th - OPEN 8am - 5.30pm
Saturday 31st - Monday 2nd - CLOSED
Tuesday 3rd - Friday 6th - OPEN 8am - 5.30pm
Saturday 7th - OPEN 9am - 4pm

Overseas orders

Postage outside of the UK is from £4.95

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*Free delivery and selected charges on orders over £49.00 mainland UK Parcelforce Zone1 for more information check the delivery info page.
 
 

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