Pexion Tablets for Dogs

Pexion Tablets for Dogs

Average Rating 5/5 (10 reviews)    
View Reviews | Review this item

Item Number: PEXION 
Phone orders quick webcode: 

Select Product Option

Select one of the options below, then click 'Buy Now'

100mg x 100 tablets £36.25 Usually despatched within 48 hours
400mg x 100 tablets £73.45 Usually despatched within 48 hours


NB This is a prescription only medicine
How do I buy Prescription medicines from you?

  1. Obtain a Prescription from your vet
  2. Place your order online or by phone
  3. Either fax email* or post your prescription to us.
  4. “Controlled Drugs” such as Epiphen or Tramadol can be only be dispensed ofter receipt of an original valid prescription sent by post. Controlled Drugs must be sent via tracked, signature delivery and do not qualify for free delivery.
  5. **Unless your vet has stated that the original must be sent to us.
  6. Choose your delivery method. Either Royal Mail Special Delivery which operates a next working day service, requiring a signature(Our recommended option). Or First class post which is free, but at your own risk, and is usually next working day but may take longer.
  7. Hyperdrug Pharmaceuticals Ltd, Middleton In Teesdale, Barnard Castle, County Durham, DL12 0NG.

You are ordering items which require a prescription, Tampering with a prescription or attempting to obtain extra unauthorise supplies is a criminal offence and will have to be reported to the authorities. “Controlled Drugs” such as Epiphen or Tramadol can be only be dispensed ofter receipt of an original valid prescription sent by post. Controlled Drugs are sent via tracked, signature delivery.

  1. Place your order online or by phone
  2. Obtain a Prescription from your vet
  3. Either post the original, fax it to 01833 641032, or email it to us at [email protected]

 I have a prescription on file
 I am sending you a prescription by email
 I am sending you a prescription by fax
 I am sending you a prescription by post


For the reduction of the frequency of generalised seizures due to idiopathic epilepsy in dogs for use after careful evaluation of alternative treatment options.

Dosage and administration:
Oral administration at a dose range of 10 mg to 30 mg imepitoin per kg bodyweight twice daily, approximately 12 hours apart. Each tablet can be halved for appropriate dosing according to the individual bodyweight of the dog. Any remaining half-tablet should be used for the next dose.

The required dose will vary between dogs and will depend on the severity of the disorder. The recommended initial dose of imepitoin is 10 mg per kg bodyweight twice daily.

Initiate therapy using the bodyweight in kg and the dosing table. If seizures are not adequately reduced following a minimum of 1 week of treatment at the current dose the supervising veterinary surgeon should re-assess the dog. Assuming that the veterinary medicinal product is well tolerated by the dog, the dose can be increased by 50 to 100% increments up to a maximum dosage of 30 mg per kg administered twice daily.

Bioavailability is greater when administered to fasted dogs. The timing of tablet administration in relation to feeding should be kept consistent.

Number of tablets (to be given twice daily) for initiation of treatment (see table 1)

Table 1: Number of tablets (to be given twice daily) for initiation of treatment


Number of tablets

Bodyweight (kg)

100 mg

400 mg




5.1 -10.0



10.1 -15.0

1 ½


15.1 - 20.0



20.1 - 40.0



40.1 - 60.0


1 ½

Over 60




Contra-indications, warnings, etc:
Do not use in case of hypersensitivity to the active substance or to any of the excipients.

Do not use in dogs with severely impaired hepatic function, severe renal or severe cardiovascular disorders.

The pharmacological response to imepitoin may vary and efficacy may not be complete. On treatment, some dogs will be free of seizures, in other dogs a reduction of the number of seizures will be observed, whilst others will be non-responders. For this reason, careful consideration should be given before deciding to switch a stabilized dog onto imepitoin from a different treatment. In non-responders, an increase in seizure frequency may be observed. Should seizures not be adequately controlled, further diagnostic measures and other antiepileptic treatment should be considered. When transition between different antiepileptic therapies is medically required, this should be done gradually and with appropriate clinical supervision.

The benefit/risk assessment for the individual dog should take into account the details in the product literature.

The efficacy of the veterinary medicinal product in dogs with status epilepticus and cluster seizures has not been investigated. Therefore, imepitoin should not be used as primary treatment in dogs with cluster seizures and status epilepticus.

No loss of anticonvulsant efficacy (tolerance development) during continuous treatment of 4 weeks was observed in experimental studies lasting 4 weeks.

Special precautions for use in animals:

The safety of the veterinary medicinal product has not been tested in dogs weighing less than 5 kg or in dogs with safety concerns such as renal, liver, cardiac, gastrointestinal or other disease. The efficacy as an add-on therapy has not been demonstrated. Mild behavioural or muscular signs may be observed in dogs upon abrupt termination of treatment with imepitoin.

The following mild and generally transient adverse reactions have been observed in pre-clinical and clinical studies in order of decreasing frequency: polyphagia at the beginning of the treatment (very common), hyperactivity, polyuria, polydipsia, somnolence, hypersalivation, emesis, ataxia, apathy, diarrhoea, prolapsed nictitating membrane, decreased sight and sensitivity to sound.

In the field, aggression has been uncommonly reported. This aggression is potentially treatment related. Aggression may also be present during the postictal period or as a behaviour change which occurs as part of disease itself.

A mild elevation in plasma creatinine and cholesterol levels has been observed in dogs treated with imepitoin; however these did not exceed the normal reference ranges and were not associated with any clinically significant observations or events.

The frequency of adverse reactions is defined using the following convention:

- very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)

- common (more than 1 but less than 10 animals in 100 animals)

- uncommon (more than 1 but less than 10 animals in 1,000 animals)

- rare (more than 1 but less than 10 animals in 10,000 animals)

- very rare (less than 1 animal in 10,000 animals, including isolated reports).

The use of the veterinary medicinal product is not recommended in male breeding dogs or in female dogs during pregnancy and lactation.

The product has been used in combination with phenobarbital in a small number of cases and no harmful clinical interactions were observed.

In case of repeated overdose of up to 5 times the highest recommended dose, central nervous system (CNS), gastrointestinal-related effects and reversible prolongation of the QT interval have been noted. At such doses, the symptoms are not usually life-threatening and generally resolve within 24 hours if symptomatic treatment is given.

These CNS effects may include loss of righting reflex, decreased activity, eyelid closure, lacrimation, dry eye and nystagmus.

At 5 times the recommended dose, decreased bodyweight may be observed.

In male dogs administered 10 times the upper recommended therapeutic dose, diffuse atrophy of seminiferous tubules in the testes and associated decreased sperm counts were seen.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

In case of accidental ingestion especially by a child, seek medical advice immediately and show the package leaflet or the label to the physician. To prevent accidental ingestion of tablets, the cap of the bottle should be replaced immediately after withdrawing the required number of tablets for one administration.

Pharmaceutical precautions:
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.

Shelf life after first opening the immediate packaging: 8 months.

Keep out of the sight and reach of children. For animal treatment only.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Legal category:

Packaging Quantities:
Cardboard box containing 1 high-density polyethylene bottle of 100 or 250 tablets with a child resistant closure. Not all pack sizes may be marketed.


Free shipping from Hyperdrug

Value Weight Delivery Charge*  
Over £49.00 Any Weight FREE*
Under £49.00 Under 250g £2.49
Under £49.00 No weight limit £4.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited delivery options are available.

Estimated " Usually shipped in" information is shown against most products


Overseas orders

Postage outside of the UK is from £4.95

Finding out delivery Charges and options before checkout

  1. Simply add an item to your basket
  2. Click view basket/Cart
  3. Click estimate shipping charges
*Free delivery and selected charges on orders over £49.00 mainland UK Parcelforce Zone1 for more information check the delivery info page.


 feefoProduct Reviews

Pexion Tablets for Dogs POM 400mg x 100 tablets

So far, happy with this treatment.

Pexion Tablets for Dogs POM 100mg x 100 tablets

Excellent and half the price of getting it supplied from the vet

Pexion Tablets for Dogs POM 400mg x 100 tablets

My dog doesn't particularly like taking the tablets, but she is still alive and she is still enjoying life, so I assume they are a benefit to her, and unless the vet suggests an alternative I shall continue to give them to her.

Pexion Tablets for Dogs POM 400mg x 100 tablets

The service is excellent, order on-line post off prescription and received with in three days. Would highly recommend the company.

Pexion Tablets for Dogs POM 400mg x 100 tablets


Pexion Tablets for Dogs POM 400mg x 100 tablets

These tablets certainly seem to help my dog, keeping her seizures under control.

Pexion Tablets for Dogs POM 400mg x 100 tablets


Pexion Tablets for Dogs POM 400mg x 100 tablets

My dog has mild epilepsy and we swithed to pexion from phenobarbitals. She is much more active and calm and her episodes have massively decreased. Highly recommend, just be aware phenobarbitals should be decreased gradually as otherwise your pet might experience withdrawal effects.

Pexion Tablets for Dogs POM 400mg x 100 tablets

Medication for my dog certainly appears to be helping her lead an active happy life.
Other products first class.

Pexion Tablets for Dogs POM 400mg x 100 tablets

great product, a lot better than phenobarbital. My dog is livelier and had had no seizures ever since on this product, would highly recommend