Panacur AquaSol 200 mg/ml oral suspension for use in drinking water for pigs and chickens.
Qualitative and quantitative composition
1 ml contains:
Fenbendazole: 200 mg
Benzyl alcohol (E1519): 20 mg
For the full list of excipients, see section “Pharmaceutical Particulars”.
White to off-white oral suspension for use in drinking water.
The suspension particles are in the sub micron size range.
Pigs and chickens.
Indications for use
Treatment and control of gastro-intestinal nematodes in pigs infected with:
- Ascaris suum (adult, intestinal and migrating larval stages)
- Oesophagostomum spp. (adult stages)
- Trichuris suis (adult stages).
Treatment of gastro-intestinal nematodes in chickens infected with:
- Ascaridia galli (L5 and adult stages)
- Heterakis gallinarum (L5 and adult stages).
Do not use in case of Capillaria spp infestations.
Special warnings for each target species
Parasitic resistance to any particular class of anthelmintic may develop following frequent repeated use of an anthelmintic of that class.
Special precautions for use
In the absence of available data, treatment of chickens less than 3 weeks of age should be based on a benefit/risk assessment by the responsible veterinarian.
The efficacy of the veterinary medicinal product at the recommended dosage is not sufficient for the treatment of infestations with Capillaria spp. The absence of Capillaria spp infestation should be confirmed prior to use of the product. In case of Capillaria infestation another appropriate anthelmintic veterinary medicinal product should be used. Use of the product deviating from the instructions in the SPC may increase the risk of development of resistance.
This veterinary medicinal product may be toxic to humans after ingestion. Embryotoxic effects cannot be excluded. This product may cause hypersensitivity reactions.
Avoid contact with skin, eye and mucous membranes. Pregnant women must take extra precautions when handling this veterinary medicinal product.
Wear protective gloves at all times while handling the veterinary medicinal product and cleaning the measuring device. Wash hands after use.
In case of skin and/or eye contact, immediately rinse with plenty of water. Remove contaminated clothes after spillage.
The veterinary medicinal product should not be allowed to enter surface waters as it has harmful effects on aquatic organisms.
Use during pregnancy, lactation or lay
Can be used during pregnancy, lactation or lay.
Amounts to be administered and administration route
For use in drinking water.
To ensure administration of the correct dose, body weight should be determined as accurately as possible; accuracy of the dosing device should be checked.
Before allowing animals to have access to the medicated water, the water delivery system should be drained, if possible, and flushed with the medicated water to ensure accuracy of dosing. This procedure may need to be performed on all treatment days.
The dose is 2.5 mg fenbendazole per kg body weight per day (equivalent to 0.0125 ml Panacur AquaSol). For the treatment and control of Ascaris suum and Oesophagostomum spp. this dose has to be administered on 2 consecutive days. For the treatment and control of Trichuris suis the dose has to be administered on 3 consecutive days.
The required daily amount of product is calculated from the total estimated body weight (kg) of the entire group of pigs to be treated. Please use the following formula:
Total estimated body weight (kg) of pigs to be treated x 0.0125 ml
= ml product/day
Examples (See also Dosage Calculation Schedule for pigs):
Panacur Aquasol Dosage Calculation Schedule for pigs
Total body weight of pigs to be treated
Day 1 amount of product
Day 2 amount of product
Day 3 amount of product
Total amount (for 2 days)
Total amount (for 3 days)
2 x 1,000 ml
3 x 1,000 ml
2 x 4,000 ml
3 x 4,000 ml
The dose is 1 mg fenbendazole per kg body weight per day (equivalent to 0.005 ml Panacur AquaSol).This dose has to be administered on 5 consecutive days.
The required daily amount of product is calculated from the total estimated body weight (kg) of the entire group of chickens to be treated. Please use the following formula:
Total estimated body weight (kg) of chickens to be treated x 0.005 ml
= ml product/day
Examples:Panacur AquaSol Dosage Calculation Schedule for chickens
Examples:Panacur AquaSol Dosage Calculation Schedule for chickens
Total body weight of chickens to be treated
Amount of product per day (ml/day)
Total amount of product (ml/for 5 days)
(5 x 200 ml)
(5 x 800 ml)
Follow the instructions in the order described below to prepare the medicated water. Use a sufficiently accurate measuring device, which should be properly cleaned after use.
For each treatment day the medicated water needs to be freshly prepared.
Prepare a predilution of the veterinary medicinal product with an equal amount of water:
a)Select a measuring device that has at least double volume of the calculated daily product volume.
b)Pour a volume of water equal to the calculated volume of product needed into the measuring device.
c)Shake the product well before mixing.
d)Fill up the measuring device containing the water with the calculated volume of the product to obtain the predilution.
e)Add the obtained predilution to the water supply system as described below.
For use in medication tank:
Add the entire content of the measuring device (predilution) to the volume of drinking water usually consumed by the animals in between 3 to 24 hours.
Stir until content in the medication tank is visibly homogeneous. The medicated water appears hazy. No further stirring during administration is necessary.
For use in dosing pump:
Add the entire content of the measuring device (predilution) to the unmedicated water in the stock suspension container of the dosing pump. The volume of unmedicated water in the stock suspension container has to be calculated taking as a basis the preset injection rate of the dosing pump and the volume of drinking water usually consumed by the animals in between 3 and 24 hours.
Stir until content in the stock suspension container is visibly homogeneous. The medicated water appears hazy.
At concentrations of up to 5 ml/l stock suspension (1 g fenbendazole/l) no stirring is required.
At concentrations above 5 ml/l stock suspension and up to 75 ml/l stock suspension (15 g fenbendazole/l) and within an up to 8 hour administration period also no stirring of the stock suspension is required. If the administration period exceeds 8 hours, but being no longer than 24 hours, the stock suspension container needs to be equipped with a stirring device.
During treatment all animals must have solely but unrestricted access to the medicated water.
During treatment, after complete consumption of the medicated water, animals must be allowed access to unmedicated drinking water as soon as possible.
Ensure that the total amount of medicated water offered is consumed.
No undesirable effects have been observed in pigs at up to ten times the recommended dose. No undesirable effects have been observed in layers and broilers (aged 21 days) at up to 5 times the recommended dose. No effects have been observed in breeders at up to 3 times the recommended dose.
Meat and offal: 4 days.
Meat and offal: 6 days.
Eggs: zero days.
Pharmacotherapeutic group: Anthelmintics, benzimidazole derivatives – fenbendazole.
ATCvet code: QP52AC13.
Fenbendazole is an anthelmintic belonging to the benzimidazole-carbamate group. It acts by interfering with the energy metabolism of the nematode.
Fenbendazole inhibits the polymerisation of tubulin to microtubules. This interferes with essential structural and functional properties of the cells of helminths, such as formation of the cytoskeleton, formation of the mitotic spindle and the uptake and intracellular transport of nutrients and metabolic products. Fenbendazole is effective and has a dose dependent effect on adult and immature stages. Fenbendazole has an ovicidal effect on nematode eggs.
After oral administration fenbendazole is only partially absorbed. Following absorption, fenbendazole is rapidly metabolised in the liver mainly to its sulphoxide (oxfendazole) and further to its sulphone (oxfendazole sulphone). In pigs oxfendazole is the main component detected in plasma, accounting for about 2/3 of the total AUC (i.e. the sum of the AUC for fenbendazole, oxfendazole and oxfendazole sulphone). In chickens oxfendazole sulfone is the main component detected in plasma, accounting for about 3/4 of the total AUC (ie the sum of the AUC for fenbendazole, oxfendazole and oxfendazole sulphone). Fenbendazole and its metabolites are distributed throughout the body, reaching highest concentrations in the liver. The elimination of fenbendazole and its metabolites occurs primarily via the faeces and to a small extent in the urine (pigs).
Polysorbate 80, Simethicone emulsion 30 %, Benzyl alcohol (E1519) and Purified water.
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
Shelf life after first opening the immediate packaging: 6 months.
Shelf life of the medicated drinking water: 24 hours.
Special precautions for storage
Do not freeze. Protect from frost.
HDPE container with pulp board/aluminium/polyester/MDPE seal closed with child-resistant polypropylene screw cap.
Pack sizes: 1 litre and 4 litres.
The 4 litre container is provided with a separate dispenser made of low density polyethylene and polypropylene.
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