PMSG-Intervet 5000 iu powder and solvent for solution for injection.
PMSG-Intervet is presented as a white, freeze-dried crystalline plug containing 5000 iu Serum Gonadotrophin (PMSG) supplied together with solvent, which when reconstituted gives a solution containing 200 iu PMSG per ml.
PMSG is capable of supplementing and being substituted for both luteinising hormone and follicle stimulating gonadotrophin of the anterior pituitary gland in both the male and female, stimulating development of the ovarian follicle.
Dosage and administration
Make up immediately before use.
Reconstitute by dissolving the powder plug in about 5 ml of the solvent provided and then syringe the resulting solution into the solvent vial to mix with the remaining solvent. Administer by subcutaneous or intramuscular injection using normal aseptic precautions.
In conjunction with the use of progestagen treatment when used for oestrus control in non-cycling cattle:
1500-4000 iu - on day 9-13 of oestrous cycle.
Anoestrus post weaning (induction of oestrus is difficult until 40 days post partum):
1000 iu - s.c. or i.m. Fertile oestrus usually follows in 3 - 7 days.
In conjunction with progestagen-releasing sponges when used out of the normal breeding season:
500 iu - s.c. or i.m. at time of sponge removal.
Oestrus induction (subnormal oestrus with non-acceptance):
20 iu/kg - s.c. daily for 10 days. At day 10 injection of 500 iu hCG.
Superovulation in cattle
The product may be used for the superovulation of female donor cattle preparatory to embryo transfer. As an example, the following regime has been successfully applied:
A single dose of the product (1500 - 4000 iu) is injected on day 9 - 13 of a normal oestrous cycle (NB the exact dose of the product required to achieve effective superovulation will depend upon a number of factors particularly the breed, age, reproductive history, general health and nutritional status of the donor female and will be subject to individual variation). Forty-eight hours after the injection, luteolysis is induced by the injection of a prostaglandin analogue. Commonly one and a half times the normal luteolytic dose is administered. Oestrus normally occurs approximately 48 hours after the prostaglandin injection. Insemination is carried out at 60 and 72 hours after prostaglandin injection.
Collection of fertilised embryos (flushing) is carried out 6-8 days after insemination, suitable embryos being transferred to female recipient cattle whose oestrous cycles have previously been synchronised with that of the donor female.
(Experience has shown that oestrous cycles in donor and recipient females should be synchronised within ± 24 hours if reasonable success is to be expected.) A further prostaglandin treatment (commonly 1½ times the luteolytic dose) must be given at the time of collection.
1.Despite the application of a suitable treatment regime certain individual donor cows may fail to respond.
2.Wide variations in response may be expected between individual animals. Repeated treatment of a single animal may also yield variable results.
3.The overall success of an embryo transfer exercise will inevitably be influenced by the availability of suitable equipment and the skill and experience of the operator.
PMSG has been used in cases of impaired spermatogenesis in male animals (horse & bull 1000-3000 iu, boar & ram 500-750 iu, dog 400-800 iu, i.m. twice weekly for 4-6 weeks), but its degree of efficacy in these cases may be low.
PMSG is a protein hormone which acts on the ovary to stimulate the production of follicles. The number of follicles produced can be influenced by the dose of PMSG administered and this must be taken into account when calculating the dose for a particular flock of ewes. In general, the further out of season that breeding is attempted and the lower the normal prolificacy of the flock, the more PMSG that will be required. An average dose of 500 iu /ewe is recommended as a useful starting point but doses ranging from 200 - 750 iu have been used on occasion. It is therefore recommended that accurate flock records are kept of breed, dose given, time of injection and lambs produced so that in future seasons the amount can, if necessary, be adjusted for optimum results.
Contra-indications, warnings, etc
Where the possibility of multiple ovulations (due to exaggerated response from prolonged blood concentrations) has not been excluded by clinical examination following administration of PMSG to uniparous species (unless to induce superovulation in cattle), it is inadvisable to permit service or insemination during the first heat produced.
In rare cases, as with all protein preparations, anaphylactoid incidents may occur shortly after injection. Adrenaline injection (1:1000) given intravenously or intramuscularly when clinical signs appear is the standard treatment. The administration of corticosteroids may also be indicated.
Repeated administration can result in reduced efficacy due to immune-mediated antagonism.
Care should be taken to avoid accidental self-injection.
Wash your hands after use.
Milk (Cattle): Zero days.
Meat (Cattle, pigs, sheep): Zero days.
Superovulation in cattle
Milk: 48 hours after 2nd prostaglandin treatment.
Meat: 28 days.
For animal treatment only. Keep out of the reach and sight of children.
Store in a refrigerator (+2°C to +8°C). Protect from light. Reconstituted product should be stored in a refrigerator (2-8°C), and reconstituted product remaining 24 hours after preparation should be discarded.
Any unused product or waste material should be disposed of in accordance with national requirements.
Clear, glass Type I Vials containing 5000 iu Serum gonadotrophin with Type I Halogenated butyl rubber stoppers with aluminium crimp caps (used by The Netherlands site).
Clear, glass Type I Vials containing 5000 iu Serum gonadotrophin with Bromobutyl rubber stoppers with aluminium crimp caps (used by the Germany site).
Colourless glass vial containing 25 ml solvent for reconstitution.
Packaged in a carton containing 1 vial of powder and 1 vial of solvent.
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