Orbenin L.A. 200 mg Intramammary Suspension
Orbenin L.A. is a suspension of cloxacillin as the sodium salt in a long acting base. It is presented in syringes containing 200 mg cloxacillin as Cloxacillin Sodium in 3 g of suspension.
For intramammary use in the treatment of clinical mastitis in lactating cows. The product is also indicated as an intramammary infusion in ewes at weaning for the treatment and prevention of mastitis.
Orbenin is active against Gram-positive organisms associated with mastitis. It is effective against Streptococcus agalactiae and other streptococcal species, penicillin-resistant and sensitive staphylococci and Arcanobacterium pyogenes. Unlike natural penicillins, Orbenin is not destroyed by staphylococcal penicillinase. It is therefore active against penicillin-resistant staphylococci which are an important cause of mastitis.
The antibiotic is bactericidal at the concentrations produced in the udder and is non-irritant to the udder tissues.
In staphylococcal and certain forms of streptococcal mastitis, an adequate duration of treatment is important in achieving both clinical and bacteriological cures. Orbenin L.A. with its slow release is designed to meet these requirements.
Dosage and administration
A course of three infusions per infected quarter – one syringe given every 48 hours. Individual syringes must only be used once.
Clean and disinfect the teat end thoroughly with surgical spirit after milking. Insert nozzle into the teat and apply gentle and continuous pressure until the suspension is expressed. The treated quarter(s) may be milked out at the next normal milking time.
A single infusion should be made into each udder half at weaning.
It is important that a simple hygienic procedure is followed. One operator should turn up and hold each ewe whilst a second person carries out the infusion technique. Clean and disinfect each teat end thoroughly with surgical spirit. Appose the syringe nozzle to the teat orifice and apply gentle, continuous pressure to express the suspension in the udder. Actual cannulation of the teat orifice is neither necessary nor desirable. Use a fresh syringe for each udder half to avoid the possibility of cross contamination during infusion.
Contra-indications, warnings, etc
Milk for human consumption must not be taken from a cow during treatment. With cows milked twice daily milk for human consumption may only be taken after 84 hours (i.e. at the 7th milking) from the last treatment.
With other milking routines, the basis of the veterinary surgeon's advice should be that milk may be taken for human consumption only after the same period from the last treatment (for example, with three times a day milking with the product administered every 48 hours, milk for human consumption may only be taken at the 11th milking).
Animals must not be slaughtered for human consumption during treatment.
Cattle and sheep may be slaughtered for human consumption only after 7 days from the last treatment.
Not for use in ewes producing milk for human consumption.
For animal treatment only.
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.
Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.
Handle this product with great care to avoid exposure, taking all recommended precautions. Wash hands after use.
If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing, are more serious symptoms and require urgent medical attention.
Do not store above 25°C. Store in a dry place.
Keep out of reach of children.
Cartons of 12 syringes.
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