Milquantel 16 mg/40 mg film-coated tablets for cats weighing at least 2 kg.
Cats (weighing at least 2 kg).
Indications for use:
In cats: treatment of mixed infections by immature and adult cestodes and nematodes of the following species:
Prevention of heartworm disease (Dirofilaria immitis) if concomitant treatment against cestodes is indicated.
Do not use in cats weighing less than 2 kg.
Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
Special warnings for each target species:
It is recommended to treat all the animals living in the same household concomitantly.
In order to develop an effective worm control programme local epidemiological information and the living conditions of the cat should be taken into account.
When D. caninum infection is present, concomitant treatment against intermediate hosts, such as fleas and lice, should be considered to prevent re-infection
Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class.
Special precautions for use:
Special precautions for use in animals:
No studies have been performed with severely debilitated cats or individuals with seriously compromised kidney or liver function. The product is not recommended for such animals or only according to a benefit/risk assessment by the responsible veterinarian.
In the event of accidental ingestion of the tablets, particularly by a child, seek medical advice immediately and show the package leaflet or the label to the doctor.
Wash hands after use.
Echinococcosis represents a hazard for humans. As Echinococcosis is a notifiable disease to the World Organisation for Animal Health (OIE), specific guidelines on the treatment and follow-up, and on the safeguard of persons, need to be obtained from the relevant competent authority.
In very rare occasions, especially in young cats, systemic signs (such as lethargy), neurological signs (such as ataxia and muscle tremors) and/or gastrointestinal signs (such as emesis and diarrhoea) have been observed after administration of the combination milbemycin/praziquantel.
Use during pregnancy, lactation or lay:
The veterinary medicinal product can be used in breeding cats including pregnant and lactating queens.
The concurrent use of the milbemycin oxime and praziquantel with selamectin is well tolerated. No interactions were observed when the recommended dose of the macrocyclic lactone selamectin was administered during treatment with milbemycin oxime and praziquantel at the recommended dose. In the absence of further studies, caution should be taken in the case of concurrent use of the product and other macrocyclic lactones. Also, no such studies have been performed with reproducing animals.
Amounts to be administered and administration route:
Animals should be weighed to ensure accurate dosing.
Minimum recommended dose rate: 2 mg of milbemycin oxime and 5 mg of praziquantel per kg are given orally as a single dose. The product should be administered with or after some food. Doing so ensures optimum protection against heartworm disease.
Depending on the body weight of the cat, the practical dosing is as follows:
2 - 4 kg
> 4- 8 kg
>8 - 12 kg
The product can be inserted into a programme for prevention of heartworm disease if at the same time treatment against tapeworms is indicated. The product has a duration of heartworm prevention of one month. For regular prevention of heartworm disease the use of a monosubstance is preferred.
In case of overdose, in addition to signs observed at the recommended dose (see section "Adverse reactions"), drooling may be observed. This sign will usually disappear spontaneously within a day.
Pharmacotherapeutic group: Endectocides, Macrocyclic lactones, milbemycin combinations
ATCVet code: QP54AB51
Milbemycin oxime belongs to the group of macrocyclic lactones, isolated from the fermentation of Streptomyces hygroscopicus var. aureolacrimosus. It is active against mites, against larval and adult stages of nematodes as well as against larvae of Dirofilaria immitis.
The activity of milbemycin is related to its action on invertebrate neurotransmission: Milbemycin oxime, like avermectins and other milbemycins, increases nematode and insect membrane permeability to chloride ions via glutamate-gated chloride ion channels (related to vertebrate GABAA and glycine receptors). This leads to hyperpolarisation of the neuromuscular membrane and flaccid paralysis and death of the parasite.
Praziquantel is an acylated pyrazino-isoquinoline derivative. Praziquantel is active against cestodes and trematodes. It modifies the permeability for calcium (influx of Ca2+) in the membranes of the parasite inducing an imbalance in the membrane structures, leading to membrane depolarisation and almost instantaneous contraction of the musculature (tetany), rapid vacuolization of the syncytial tegument and subsequent tegumental disintegration (blebbing), resulting in easier expulsion from the gastrointestinal tract or death of the parasite.
In cats under fed condition, praziquantel reaches peak plasma concentrations within 3 hours after oral administration.
The half life of elimination is around 2 hours.
After oral administration in cats under fed condition, milbemycin oxime reaches peak plasma concentrations within 5 hours. The half life of elimination is around 43 hours (± 21 hours).
In the rat, metabolism appears to be complete although slow, since unchanged milbemycin oxime has not been found in urine or feces. Main metabolites in the rat are monohydroxylated derivatives, attributable to hepatic biotransformation. In addition to relatively high liver concentrations, there is some concentration in fat, reflecting its lipophilicity.
Silica, colloidal anhydrous
Titanium dioxide (E171)
Iron Oxide, red (E172)
Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
Shelf life for halved tablets after first opening the immediate packaging: 6 months.
Special precautions for storage:
Store in the original package in order to protect from moisture.
Halved tablets should be stored below 25°C in the original blister and be used for the next administration.
Blister packs consisting of cold formed OPA/Al/PVC foil and aluminium foil.
Box with 1 blister of 2 tablets.
Box with 1 blister of 4 tablets.
Box with 12 blisters, each blister contains 4 tablets.
Not all pack sizes may be marketed.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
The product should not enter water courses as this may be dangerous for fish and other aquatic organisms.
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