Milprazon 16mg/40mg Tablets for Cats weighing at least 2kg.
Cats (weighing at least 2 kg).
In cats: treatment of mixed infections by immature and adult cestodes and
nematodes of the following species:
Prevention of heartworm disease (Dirofilaria immitis) if concomitant treatment against
cestodes is indicated.
Do not use in cats weighing less than 2 kg.
Do not use in cases of hypersensitivity to the active substances or to any of the
Special warnings for each target species
It is recommended to treat all the animals living in the same household
In order to develop an effective worm control programme local epidemiological
information and the risk of exposure of the cat should be taken into account.
When D. caninum infection is present, concomitant treatment against intermediate
hosts, such as fleas and lice, should be considered to prevent re-infection.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class.
Special precautions for use
Special precautions for use in animals
No studies have been performed with severely debilitated cats or individuals with
seriously compromised kidney or liver function. The product is not recommended for
such animals or only according to a benefit/risk assessment by the responsible
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
In the event of accidental ingestion of the tablets, particularly by a child, seek medical
advice immediately and show the package leaflet or the label to the doctor.
Wash hands after use.
Echinococcosis represents a hazard for humans. As Echinococcosis is a notifiable
disease to the World Organisation for Animal Health (OIE), specific guidelines on the
treatment and follow-up, and on the safeguard of persons, need to be obtained from
the relevant competent authority.
Adverse reactions (frequency and seriousness)
On very rare occasions, especially in young cats, systemic signs (such as lethargy),
neurological signs (such as ataxia and muscle tremors) and/or gastrointestinal signs
(such as emesis and diarrhoea) have been observed after administration of the
Use during pregnancy, lactation or lay
The veterinary medicinal product can be used in breeding cats including pregnant
and lactating queens.
Interaction with other medicinal products and other forms of interaction
The concurrent use of the milbemycin oxime and praziquantel with selamectin is well
tolerated. No interactions were observed when the recommended dose of the
macrocyclic lactone selamectin was administered during treatment with milbemycin
oxime and praziquantel at the recommended dose. In the absence of further studies,
caution should be taken in the case of concurrent use of the product and other
macrocyclic lactones. Also, no such studies have been performed with reproducing
Amounts to be administered and administration route
Animals should be weighed to ensure accurate dosing.
Minimum recommended dose rate: 2 mg of milbemycin oxime and 5 mg of
praziquantel per kg are given orally as a single dose. The product should be
administered with or after some food. Doing so ensures optimum protection against
Depending on the bodyweight of the cat, the practical dosing is as follows:
Weight Film-coated tablets for cats
2 - 4 kg ½ tablet
> 4 - 8 kg 1 tablet
> 8 - 12 kg 1½ tablets
The product can be inserted into a programme for prevention of heartworm disease if
at the same time treatment against tapeworms is indicated. The product has a
duration of heartworm prevention of one month. For regular prevention of heartworm
disease the use of a monosubstance is preferred.
Overdose (symptoms, emergency procedures, antidotes), if necessary
In case of overdose, in addition to signs observed at the recommended dose, drooling may be observed. This sign will usually disappear spontaneously within
Pharmacotherapeutic group: Endectocides, Macrocyclic lactones, milbemycin,
ATCvet code: QP54AB51
Milbemycin oxime belongs to the group of macrocyclic lactones, isolated from the
fermentation of Streptomyces hygroscopicus var. aureolacrimosus. It is active against
mites, against larval and adult stages of nematodes as well as against larvae of
The activity of milbemycin is related to its action on invertebrate neurotransmission:
Milbemycin oxime, like avermectins and other milbemycins, increases nematode and
insect membrane permeability to chloride ions via glutamate-gated chloride ion
channels (related to vertebrate GABAA and glycine receptors). This leads to
hyperpolarisation of the neuromuscular membrane and flaccid paralysis and death of
Praziquantel is an acylated pyrazino-isoquinoline derivative. Praziquantel is active
against cestodes and trematodes. It modifies the permeability for calcium (influx of
Ca2+) in the membranes of the parasite inducing an imbalance in the membrane
structures, leading to membrane depolarisation and almost instantaneous contraction
of the musculature (tetany), rapid vacuolization of the syncytial tegument and
subsequent tegumental disintegration (blebbing), resulting in easier expulsion from
the gastrointestinal tract or death of the parasite.
In cats under fed condition, praziquantel reaches peak plasma concentrations within
3 hours after oral administration.
The half life of elimination is around 2 hours.
After oral administration in cats under fed condition, milbemycin oxime reaches peak
plasma concentrations within 5 hours. The half life of elimination is around 43 hours
(± 21 hours).
In the rat, metabolism appears to be complete although slow, since unchanged
milbemycin oxime has not been found in urine or feces. Main metabolites in the rat
are monohydroxylated derivatives, attributable to hepatic biotransformation. In
addition to relatively high liver concentrations, there is some concentration in fat,
reflecting its lipophilicity.
List of excipients
Silica, colloidal anhydrous
Titanium dioxide (E171)
Iron Oxide, yellow (E172)
Shelf life of the veterinary medicinal product as packaged for sale: 2 years
Shelf life for halved tablets after first opening the immediate packaging: 3 months.
Special precautions for storage
Store in the original package in order to protect from moisture. This veterinary
medicinal product does not require any special temperature storage conditions.
Halved tablets should be stored below 25°C in the original blister and be used for the
Keep the blister in the outer carton.
Nature and composition of immediate packaging
Blister packs consisting of cold formed OPA/Al/PVC foil and aluminium foil.
Box with 1 blister of 2 tablets.
Box with 1 blister of 4 tablets.
Box with 12 blisters, each blister contains 4 tablets.
Not all pack sizes may be marketed.
Special precautions for the disposal of unused veterinary medicinal
product or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such
veterinary medicinal product should be disposed of in accordance with local
The product should not enter water courses as this may be dangerous for fish and
other aquatic organisms.
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