- Non-insulin-dependent diabetes (NIDDM, type II) and, in particular, in obese patients, when adequate dietary treatment has failed.
- Metformin 850 mg Tablets can be given alone as initial therapy, or can be administered in combination with sulphonylureas after careful assessment of the contra-indications.
Posology and method of administration
Adults with normal renal function (GFR= 90mL/min)
The required daily dose ranges from 500mg to 3 g. Therapy should be initiated with a low dose of 500mg or 850mg daily. Depending on the metabolic state the dose can be increased stepwise at intervals of a few days up to two weeks until the therapeutically required dose has been reached. In order to minimise the gastro-intestinal side-effects the daily dose should be divided and taken with or after meals. Generally, daily doses of 1000mg to 1700mg are sufficient. If diabetic control is incomplete a cautious increase in dosage to a maximum of 2 to 3g daily is justified. No additional benefit can usually be achieved by use of doses exceeding 3g daily. Once control has been achieved it may be possible to reduce the daily dose.
For full data sheet go to:https://www.medicines.org.uk/emc/product/2414/smpc
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