Myasthenia gravis, paralytic ileus and post-operative urinary retention.
Posology and method of administration
Doses of 30 to 120mg are given at intervals throughout the day when maximum strength is needed (for example, on rising and before mealtimes). The usual duration of action of a dose is 3 to 4 hours in the daytime but a longer effect (6 hours) is often obtained with a dose taken on retiring for bed.
The total daily dose is usually in the range of 5 – 20 tablets but doses higher than these may be needed by some patients.
Children under 6 years old should receive an initial dose of half a tablet (30mg) of Mestinon; children 6 – 12 years old should receive one tablet (60mg). Dosage should be increased gradually, in increments of 15 – 30mg daily, until maximum improvement is obtained. Total daily requirements are usually in the range to 30 – 360mg.
Other Indications (paralytic ileus, post-operative urinary retention)
The usual dose is 1 to 4 tablets (60 – 240mg) per day.
The usual dose is 15 – 60mg per day.
The frequency of these doses may be varied according to the needs of the patient.
There are no specific dosage recommendations for Mestinon in elderly patients.
Mestinon is mainly excreted unchanged by the kidney, therefore lower doses may be required in patients with renal disease and treatment should be based on titration of drug dosage to effect.
There are no specific dosage recommendations for Mestinon in patients with hepatic impairment.
Method of administration
For oral use
For full data sheet go to:https://www.medicines.org.uk/emc/product/962/smpc
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