Marbocyl 2% is presented as a sterile solution for injection.
Marbofloxacin 2.0% w/v
Disodium edetate 0.01% w/v
Thioglycerol 0.05% w/v
Metacresol 0.2% w/v
In pre-ruminant cattle up to 100kg bodyweight and pigs, Marbofloxacin 2 % is indicated in the treatment of respiratory infections caused by susceptible strains of organisms.
The recommended dosage is 2 mg/kg/day (1 ml/10 kg) in a single daily injection by subcutaneous or intravenous routes in cattle and by the intramuscular route in pigs.
Treatment duration is 3 - 5 days by the intravenous route in cattle, 3 days by the subcutaneous route in cattle, and 3 - 5 days by the intramuscular route in pigs.
The volume of injection should be limited to 10ml at each site of injection for pigs.
In order to reduce the risk of particulate contamination of the product, it is recommended that a draw-off needle be used to reduce the number of times the septum is punctured.
Special Precautions for use in Animals
Official and local antimicrobial policies should be taken into account when the product is used. Fluoroquinolones should be reserved for the treatment of clinical conditions which have responded poorly, or are expected to respond poorly, to other classes of antimicrobials. Wherever possible, fluoroquinolones should only be used based on susceptibility testing. Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to the fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due to the potential for cross resistance.
No severe side-effects are to be expected at doses up to 5 times the recommended dose in cattle and pigs. In particular no lesions of the articular joints are encountered.
Subcutaneous injection is well tolerated. Transitory inflammatory reactions are sometimes observed at the injection site, but without clinical impact.
Overdosage may cause acute signs in the form of neurological disorders which should be treated symptomatically.
People with known hypersensitivity to fluoroquinolones should avoid using this product. Wash hands after use.
Preruminating calves (up to 100kg bodyweight): 6 days
Pigs: 4 days
Following withdrawal of the first dose, use the product within 28 days. Discard unused material.
Do not store above 25°C. Protect from light.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Manure and slurry containing marbofloxacin should not be spread on the same area of land in successive years.
Packaged in amber type II glass vials of 10, 20, 50ml, 100 ml and 250ml.
The vials are closed with a chlorobutyl rubber stopper oversealed with aluminium caps.
Each vial is packaged in a cardboard box.
Not all pack sizes may be marketed.
ATC Vet Code: QJ01MA93
Marbofloxacin is a synthetic, bactericidal antimicrobial, belonging to the fluoroquinolone group which acts by inhibition of DNA gyrase. It is effective against a wide range of Gram positive bacteria (in particular Staphylococci) and Gram negative bacteria (Escherichia coli, Salmonella typhimurium, Campylobacter jejunii, Citrobacter, Enterobacter, Proteus spp,Klebsiella spp Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Pasteurella haemolytica, Pasteurella multocida, Haemophilus spp, Moraxella spp, Pseudononas aeruginosa) as well as Mycoplasma (Mycoplasma bovis, Mycoplasma dispar, Mycoplasma hyopneumoniae).
Resistance to Streptococcus may occur.
After subcutaneous administration in cattle and pigs at the recommended dose of 2 mg/kg, marbofloxacin is readily absorbed and its bioavailability is close to 100 %. It is weakly bound to plasma proteins (less than 10 % in pigs and 30 % in cattle), extensively distributed and, in most tissues (liver, kidney, skin, lung, bladder, uterus, digestive tract), it achieves higher concentrations than in plasma.
In cattle, marbofloxacin is eliminated slowly in pre-ruminating calves (t1/2ß = 5-9 h) predominantly in the active form in urine (3/4) and faeces (1/4).
In pigs, marbofloxacin is eliminated slowly (t1/2ß = 8-10 h) predominantly in the active form in urine (2/3) and faeces (1/3).
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