Domitor 1 mg/ml Solution for Injection 10ml

Domitor 1 mg/ml Solution for Injection 10ml


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Item Number: DOMITORI 
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Unit Price:

£95.85 (Incl. Vat)

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NB This is a prescription only medicine
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  7. Hyperdrug Pharmaceuticals Ltd, Middleton In Teesdale, Barnard Castle, County Durham, DL12 0NG.
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Description

Domitor 1 mg/ml Solution for Injection 10ml.

Uses

Dogs

For restraint, sedation and analgesia associated with clinical examinations and procedures, minor surgery and pre-anaesthesia.

As a premedicant before thiopentone-halothane general anaesthesia and as a premedicant before general anaesthesia with propofol.

In combination with butorphanol for sedation and analgesia, and as a premedicant to thiopentone anaesthesia.

Cats

For restraint and sedation.

In combination with ketamine for induction of general anaesthesia prior to surgical procedures in the cat.

In combination with butorphanol for sedation and analgesia, and combined with both butorphanol and ketamine for general anaesthesia.

As a premedication before alphaxalone/alphadolone for general anaesthesia.

Dosage and administration

An appropriately graduated syringe must be used to allow accurate administration of the required dose volume. This is particularly important when injecting small volumes. Medetomidine has marked anaesthetic sparing effects. It is essential to reduce the dose of induction and maintenance agents appropriately in animals that have been premedicated with Domitor.

DOGS

Domitor alone for canine sedation and analgesia

For parenteral use by intramuscular (IM), intravenous (IV) or subcutaneous (SC) injection.

Animal

Dose

micrograms/kg

Effect

Quantity

Dog

10 - 30

Slight

sedation

0.1 - 0.3 ml/

10 kg

Dog

30 - 80

Moderate

to deep

sedation and

analgesia

0.3 - 0.8 ml/

10 kg

Dog

10 - 20

Pre-

anaesthesia

0.1 - 0.2 ml/

10 kg

Maximal effect is obtained within 10 - 15 minutes. Duration of the clinically useful effect is dose-dependent (30 - 180 minutes). The dose can be repeated if necessary. Animals should be fasted for 12 hours prior to anaesthesia.

Domitor with butorphanol for canine sedation and analgesia

Medetomidine (Domitor) and butorphanol can be administered together in the same syringe, by IM or IV injection.

Dose rate: 10-25 mcg/kg medetomidine (0.01 - 0.025 ml/kg Domitor), depending on the degree of sedation required, plus 0.1mg/kg butorphanol (0.01ml/kg of 10mg/ml solution). Allow 20 minutes for sedation to develop before commencing the procedure.

Reversal with an equal volume of Antisedan IM to that of Domitor used results in sternal recumbency approximately 5 minutes later and standing approximately a further 2 minutes later.

Domitor with butorphanol followed by thiopentone anaesthesia

Dose rate: medetomidine 10 mcg/kg (0.01 ml/kg Domitor) and butorphanol 0.1mg/kg (0.01ml/kg of 10mg/ml solution).

Medetomidine and butorphanol can be administered together in the same syringe, by IM or IV injection.

Allow 20 minutes for sedation to develop before administering thiopentone.

Atipamezole (Antisedan) administered in the post-operative phase will hasten the recovery from anaesthesia.

Canine doses (ml) for mild sedation, or premedication prior to thiopentone, IM or IV:

  


Domitor 1mg/ml

butorphanol 10mg/ml

kg

10mcg/kg medetomidine

0.1 mg/kg

1

0.01

0.01

3

0.03

0.03

5

0.05

0.05

10

0.10

0.10

15

0.15

0.15

20

0.20

0.20

25

0.25

0.25

30

0.30

0.30

40

0.40

0.40

Canine doses (ml) for deep sedation:

 

Domitor 1mg/ml

butorphanol 10mg/ml

kg

25 mcg/kg medetomidine

0.1 mg/kg

1

0.03

0.01

3

0.075

0.03

5

0.13

0.05

10

0.25

0.10

15

0.38

0.15

20

0.50

0.20

25

0.63

0.25

30

0.75

0.30

40

1.00

0.40

Domitor as a premedicant before thiopentone in dogs, anaesthesia being maintained with halothane (with or without nitrous oxide)

Medetomidine (Domitor) is administered at least 20 minutes before thiopentone (induction agent) to allow sedation to develop. Domitor may be administered at a dose rate of 10, 20 or 40 mcg/kg. The table below is a guideline for doses, however, the dose of thiopentone required may vary considerably in individual animals. The optimum dose of Domitor is in the range of 20 - 40 mcg/kg and will depend on the temperament of the dog. At higher doses of medetomdine, thiopentone may not be required for intubation, i.e. intubation may be possible under medetomidine alone.

Medetomidine

Domitor

Thiopentone

 

Dose in

mcg/kg

Quantity in ml/10 kg

Dose in

mg/kg

ml/ 10kg of 2.5% solution

10

0.1

6.9

2.76

20

0.2

4.5

1.8

40

0.4

2.4

0.96

Thiopentone as a dilute solution (1.25 - 2.5%) is administered by the IV route slowly to effect over a period of 30 - 45 seconds. Once jaw relaxation is considered adequate, tracheal intubation can be undertaken.

N.B. Onset of unconsciousness may be delayed for up to one minute following injection of thiopentone. Therefore, slow IV injection is required as indicated above.

After intubation, anaesthesia may be maintained with halothane in oxygen (with or without nitrous oxide) administered to effect. Recovery from anaesthesia may take from 20 to over 60 minutes.

Food should be withheld for 12 hours prior to anaesthesia.

For recoveries in excess of one hour it is advisable to administer atipamezole (Antisedan).

Domitor as a premedicant before propofol in dogs.

Medetomidine (Domitor) is administered either IV at least 10 minutes before propofol (induction agent), or IM at least 20 minutes before propofol to allow sedation to develop. Medetomidine may be administered at a dose rate of 10, 20 or 40 mcg/kg (0.01, 0.02 or 0.04 ml/kg). The following table is a guideline for doses:

Medetomidine

Domitor

Propofol

 

Dose in mcg/kg

Quantity in ml/10 kg

Dose in mg/kg

Quantity in ml/10 kg of 10mg/ml emulsion

10

0.1

1.5

1.5

20

0.2

1.1

1.1

40

0.4

1.0

1.0

Following premedication with medetomidine, doses of propofol of up to 4 mg/kg (e.g. 0.4ml/kg of 10mg/ml emulsion) have been safely used when a greater depth of anaesthesia is required.

N.B. The induction time is increased following Domitor premedication; propofol should be administered by slow IV injection and up to 2.5 minutes should be allowed before a further dose is given.

Once jaw relaxation is adequate, tracheal intubation can be undertaken. It is advisable to administer oxygen during anaesthesia. For maintenance of anaesthesia the dose of propofol is markedly reduced by medetomidine premedication. Infusion doses of 0.06 to 0.35 mg/kg/minute (e.g. 0.006 - 0.035ml/kg/minute of a 10mg/ml emulsion) will provide stable anaesthesia for dogs sedated with between 40 and 10 mcg/kg Domitor respectively. For intermittent bolus administration, a dose of 1 mg/kg (e.g. 0.1ml/kg of a 10mg/ml emulsion) at intervals of between 4 and 12 minutes will provide stable anaesthesia.

Recovery from anaesthesia may take from 20 to greater than 60 minutes.

Food should be withheld for 12 hours prior to anaesthesia.

Atipamezole (Antisedan) administered in the post-operative phase will hasten the recovery from anaesthesia.

CATS

Domitor alone for feline sedation

For parenteral use by IM or SC injection.

Animal

Dose mcg/kg

Effect

Quantity

Cat

50 - 100

Moderate sedation

0.25 - 0.50 ml/5 kg

Cat

100 - 150

Deep sedation

0.50 - 0.75 ml/5 kg

Maximal effect is obtained within 10 - 15 minutes. Duration of the clinically useful effect is dose related (30 - 180 minutes). The dose can be repeated if necessary. Animals should be fasted for 12 hours prior to anaesthesia.

Domitor with butorphanol for feline sedation and analgesia

Medetomidine (Domitor) and butorphanol can be administered together in the same syringe, by IM or SC injection.

Dose rate: Medetomidine 50 mcg/kg (0.05 ml/kg Domitor), depending on the degree of sedation required, plus 0.4mg/kg butorphanol (0.04ml/kg of 10mg/ml solution). Allow 20 minutes for sedation to develop before commencing the procedure.

Local anaesthetic infiltration should be used for wound suturing.

Reversal with half the volume of Antisedan to that of the previously administered Domitor results in sternal recumbency approximately 4 minutes later and standing approximately a further 2 minutes later. See table.

Feline doses (ml) for sedation with Domitor and butorphanol IM or SC:

  


Domitor 1mg/ml

butorphanol 10mg/ml

kg

50 mcg/kg medetomidine

0.4 mg/kg

1

0.05

0.04

1.5

0.08

0.06

2

0.10

0.08

2.5

0.13

0.10

3

0.15

0.12

3.5

0.18

0.14

4

0.20

0.16

4.5

0.23

0.18

5

0.25

0.20

Domitor with ketamine for feline anaesthesia

Medetomidine (Domitor) and ketamine are administered concomitantly, in the same syringe, by the IM route. To minimise the possibility of cross contamination, the vials of each product should have separate needles inserted for withdrawal. Medetomidine should be administered at a rate of 80 mcg/kg (0.08 ml/kg Domitor) with a concomitant dose of 2.5 - 7.5 mg/kg ketamine (0.025 - 0.075ml/kg of 100mg/ml solution). Atropine is not normally necessary when using a medetomidine/ketamine combination.

Using this regime the average onset of anaesthesia is 3 - 4 minutes and surgical anaesthesia can be expected to last between 30 and 50 minutes. If required, anaesthesia may be prolonged with halothane and oxygen with or without nitrous oxide.

Food should be withheld for 12 hours prior to anaesthesia.

Domitor, butorphanol and ketamine for feline anaesthesia

a) IM

Dosage: Medetomidine 80 mcg/kg (0.08ml/kg Domitor), butorphanol 0.4mg/kg (0.04ml/kg of 10mg/ml solution) and ketamine 5mg/kg (0.05ml/kg of 100mg/ml solution) should be given in a single syringe

Cats become recumbent in 2-3 minutes following injection. Loss of the pedal reflex occurs 3 minutes post injection.

Reversal with atipamezole 200 mcg/kg ( 0.04 ml/kg Antisedan) results in return of the pedal reflex 2 minutes later, sternal recumbency 6 minutes later and standing 31 minutes later.

Feline doses (ml) for IM Domitor/butorphanol/ketamine anaesthesia:

  


Domitor 1mg/ml

butorphanol 10mg/ml

ketamine 100 mg/ml

kg

80 mcg/kg medetomidine

0.4 mg/kg

5mg/kg

1.5

0.12

0.06

0.075

2

0.16

0.08

0.10

2.5

0.20

0.10

0.125

3

0.24

0.12

0.15

3.5

0.28

0.14

0.175

4

0.32

0.16

0.20

4.5

0.36

0.18

0.225

5

0.40

0.20

0.25

Approximate time scales in IV Domitor / butorphanol / ketamine anaesthesia:

Ketamine dose

1.25 mg/kg

2.5 mg/kg

Time to recumbency

32 secs

22 secs

Time to loss of pedal reflex

62 secs

39 secs

Time to return of pedal reflex

26 mins

28 mins

Time to sternal recumbency

54 mins

62 mins

Time to standing

74 mins

83 mins

Domitor followed by alphaxalone/alphadolone for feline general anaesthesia

Dosage: Administer medetomidine 80 mcg/kg (0.08ml/kg Domitor) by IM or SC injection.

15 - 60 minutes later administer 2.5 - 5.0 mg/kg alphaxalone/alphadolone ( e.g. 0.208 - 0.416 ml/kg of a 12mg/ml solution) IV.

Anaesthesia may be maintained by further IV injections of alphaxalone/alphadolone, or by administration of halothane in oxygen.

Feline doses (ml) for Domitor( IM or SC) plus alphaxalone/alphadolone (IV) anaesthesia:

  


Domitor 1mg/ml

alphaxalone 9mg/ml + alphadolone

3 mg/ml

alphaxalone 9mg/ml + alphadolone

3 mg/ml

kg

80 mcg/kg medetomidine

minimum dose

2.5 mg/kg

maximum dose

5 mg/kg

1

0.08

0.21

0.42

1.5

0.12

0.31

0.63

2

0.16

0.42

0.83

2.5

0.20

0.52

1.04

3

0.24

0.63

1.25

3.5

0.28

0.73

1.46

4

0.32

0.83

1.67

4.5

0.36

0.94

1.88

5

0.40

1.04

2.08

Packaging Quantities

10 ml clear glass vials.

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