Dermipred 10mg Chewable Tablets for Dogs (pack of 96).
Dermipred 10mg Chewable Tablets are used for the symptomatic treatment of or alongside other treatments for inflammatory and immune-mediated dermatitis in dogs. This tablet can be divided into two or four equal parts.
Dosage and administration
For oral administration
The dose and total duration of treatment is determined by the veterinarian per individual case depending on the severity of symptoms. The lowest effective dose must be used.
- for dermatitis requiring an anti-inflammatory dose: 0.5 mg per kg bodyweight twice a day.
- for dermatitis requiring an immunosuppressive dose: 1 - 3 mg per kg bodyweight twice a day.
For longer term treatment: when after a period of daily dosing the desired effect has been achieved, the dose should be reduced until the lowest effective dose is reached. The reduction of the dose should be made by alternate day therapy and /or by halving the dose with intervals of 5-7 days until the lowest effective dose is reached.
Number of tablets for a dose regimen of 1 mg/kg/day in two equally divided doses - equivalent to the anti-inflammatory dose of 0.5 mg/kg BID
|Body weight (kg) 0.5mg/kg||Dermipred 5 mg Number of tablets (twice daily)||Dermipred 10 mg Number of tablets (twice daily)||Dermipred 20 mg Number of tablets (twice daily)|
|3 – 5||½||¼|
|6 – 10||1||½||¼|
|11 – 15||¾|
|16 – 20||1||½|
|21 – 25||1 ¼|
|26 – 30||¾|
|31 – 40||1|
Spontaneous intake by the animal or place the tablet behind the lingual torus.
Contra-indications, warnings, etc
Do not use in animals with:
- Viral, mycotic or parasitic infections that are not controlled with an appropriate treatment
- Diabetes mellitus
- Heart failure
- Severe renal insufficiency
- Corneal ulceration
- Gastro-intestinal ulceration
Do not use concomitantly with attenuated live vaccines
Do not use in known cases of hypersensitivity to the active substance, to other corticosteroids, or to any of the excipients.
Use during pregnancy, lactation
Corticosteroids are not recommended for use in pregnant animals. Administration in early pregnancy is known to have caused foetal abnormalities in laboratory animals. Administration in late pregnancy may cause early parturition or abortion.
Glucocorticoids are excreted in the milk and may result in growth impairment in suckling young animals. Consequently, the product should be used only according to the benefit / risk assessment of the responsible veterinary surgeon in lactating bitches.
Interaction with other medicinal products and other forms of interaction
Phenytoin, barbiturates, ephedrine and rifampicin may accelerate the metabolic clearance of corticosteroids resulting in decreased blood levels and reduced physiological effect.
The concomitant use of this veterinary medicinal product with non-steroidal anti-inflammatory drugs may exacerbate gastrointestinal tract ulceration.
Administration of prednisolone may induce hypokalaemia and hence increase the risk of toxicity from cardiac glycosides. The risk of hypokalaemia may be increased if prednisolone is administered together with potassium depleting diuretics. Precautions need to be taken when combining use with insulin.
Adverse reactions (frequency and seriousness)
Anti-inflammatory corticosteroids, such as prednisolone, are known to exert a wide range of side effects. Whilst single high doses are generally well tolerated, they may induce severe side-effects in long term use.
The significant dose related cortisol suppression noticed during therapy is a result of effective doses suppressing the hypothalamic-pituitary-adrenal-axis. Following cessation of treatment, signs of adrenal insufficiency can arise and this may render the animal unable to deal adequately with stressful situations.
The significant increase in triglycerides noticed can be a part of possible iatrogenic hyperadrenocorticism (Cushing’s disease) involving significant alteration of fat, carbohydrate, protein and mineral metabolism, e.g. redistribution of body fat, increase in body weight, muscle weakness, wastage and osteoporosis may result. Cortisol suppression and an increase in plasma triglycerides is a very common side-effect of medication with corticoids (more than 1 in 10 animals).
Changes in biochemical, haematological and liver parameters probably associated with the use of prednisolone were significant effects noticed on alkaline phosphatase (increase), lactate dehydrogenase (decrease), albumin (increase), eosinophils, lymphocytes (decrease), segmented neutrophils (increase), alkaline phosphatase (increase) and serum hepatic enzymes (increase). A decrease in aspartate transaminase is also noticed.
Systemically administered corticosteroids may cause polyuria, polydipsia and polyphagia, particularly during the early stages of therapy. Some corticosteroids may cause sodium and water retention and hypokalaemia in long term use. Systemic corticosteroids have caused deposition of calcium in the skin (calcinosis cutis).
Corticosteroid use may delay wound healing and the immunosuppressant actions may weaken resistance to or exacerbate existing infections.
Gastrointestinal ulceration has been reported in animals treated with corticosteroids and gastrointestinal ulceration may be exacerbated by steroids in animals given non-steroidal anti-inflammatory drugs and in animals with spinal cord trauma.
Other adverse reactions that may occur are: inhibition of longitudinal growth of bones; skin atrophy; diabetes mellitus; behavioral disorders (excitation and depression), pancreatitis, decrease in thyroid hormone synthesis; increase in parathyroid hormone synthesis.
An overdose will not cause other effects than those stated in the adverse reaction section.
There is no specific antidote.
Special warnings for each target species
Corticoid administration is to induce an improvement in clinical signs rather than a cure. The treatment should be combined with treatment of the underlying disease and/or environmental control.
Special precautions for use in animals:
In cases where a bacterial infection is present the product should be used in association with suitable antibacterial therapy. Pharmacologically-active dose levels may result adrenal insufficiency. This may become apparent particularly after withdrawal of corticosteroid treatment. This effect may be minimised by institution of alternate-day therapy if practical. The dosage should be reduced and withdrawn gradually to avoid precipitation of adrenal insufficiency (see Dosage & Administration).
Corticoids such as prednisolone, exacerbate proteinaceous catabolism. Consequently, the product should be carefully administered in old or malnourished animals.
Corticoids such as prednisolone should be used with caution in patients with hypertension, epilepsy, burns, previous steroid myopathy, in immunocompromised animals and in young animals as corticosteroids may induce a delayed growth.
Treatment with the veterinary medicinal product may interfere with vaccination efficacy. When vaccinating with attenuated live vaccines, a two week interval should be observed before or after treatment.
Special monitoring is required in animals presenting with renal insufficiency. Use only after careful benefit-risk assessment by the responsible veterinarian.
The chewable tablets are flavoured. In order to avoid any accidental ingestion, store tablets out of reach of the animals.
Special precautions for the person administering the veterinary medicinal product to animals:
In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.
People with known hypersensitivity to prednisolone or other corticosteroids, or any of the excipients, should avoid contact with the veterinary medicinal product.
Corticosteroids can cause foetal malformations; therefore it is recommended that pregnant women avoid contact with the veterinary medicinal product.
Immediately wash hands thoroughly after handling the tablets.
Legal category: POM-V
Blister containing 10 tablets.
10mg: Cardboard box with 96 tablets
20mg: Cardboard box with 100 tablets
Do not store above 30°C
Any unused tablet portion should be returned to the blister and be used for the next administration.
Shelf life of the veterinary medicinal product as packaged for sale:
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