Each vial of 1 ml contains 10, 20, 30 or 40 mg Lokivetmab.
Lokivetmab is a caninised monoclonal antibody expressed through recombinant techniques in Chinese hamster ovary (CHO) cells.
Indicated for the treatment of clinical manifestations of atopic dermatitis in dogs.
For subcutaneous use. Avoid excessive shaking or foaming of the solution. Administer the entire contents (1 ml) of the vial.
Dose according to the dosing chart below. For dogs above 40 kg, the contents of more than one vial are required to administer in a single dose. In those cases, withdraw the appropriate content from each required vial into the same syringe. To allow for mixing of the solution, gently invert the syringe three or four times before administering.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
Do not use in dogs less than 3 kg bodyweight.
Lokivetmab may induce transient or persistent anti-drug antibodies. The induction of such antibodies is uncommon and may have no effect (transient anti-drug antibodies) or may result in a noticeable decrease in efficacy (persistent anti-drug antibodies) in animals that responded to treatment previously.
In cases of atopic dermatitis, it is recommended to investigate and treat complicating factors, such as bacterial, fungal or parasitic infections/infestations (e.g. flea and mange).
It is recommended to monitor dogs for bacterial infections associated with atopic dermatitis, especially during the first weeks of treatment.
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