Cosecure Bolus for Cattle.
Cattle (over 2 months and weighing at least 100 kg BW).
Indications for use:
For prevention and treatment of copper and selenium deficiencies and for improvement of cobalt supply.
Do not administer to non-ruminating calves or to animals weighing less than 100kg body weight. Do not administer to sheep.
Special warnings for each target species:
The product is not intended for treatment of acute clinical conditions such as nutritional muscular dystrophy.
Special precautions for use:
Special precautions for use in animals:
Prior to supplementation with any form of copper or selenium, it should be demonstrated that there is a need for extra trace elements to be given to the animals. Additional copper should not be administered orally or by injection, or selenium by injection ,within six months after administration of the product to cattle at pasture or within 4.5 months in cattle where the diet is supplemented with concentrates unless subjected to a risk/benefit analysis performed by a responsible veterinarian in each case.
Do not administer any aids to alter dissolution of the bolus. The boluses are sensitive to sudden temperature changes such as those that may occur when very cold boluses are swallowed by an animal. Therefore it is important that the bolus is at room temperature (15 - 20 degrees Celsius) prior to administration to prevent the development of fine cracks that may change the activity of the bolus.
Special precautions to be taken by the person administering the veterinary medicinal product to animals:
In order to minimise the risk of contact allergy, wear gloves when handling this product.
Use during pregnancy, lactation or lay
The product may be administered to pregnant and lactating animals.
Amounts to be administered and administration route:
Ruminating cattle over two months of age and weighing over 100kg bodyweight: 2 boluses.
Administer orally using an oesophageal balling-gun, which delivers the bolus directly into the top of the gullet. Great care should be taken not to cause any injury by rough handling or by placing the gun too far inside the throat of the animal. Ensure that each animal has swallowed the boluses by holding the mouth closed and observing the animal for a short time after dosing.Gentle massage of the throat may facilitate swallowing of the boluses. The boluses should normally be administered just before turnout, but administration may be carried out at any time, e.g. administer to dairy cows at drying off or at calving or 30 days post- calving or at artificial insemination.
The boluses are sensitive to sudden temperature changes such as those that may occur when very cold boluses are swallowed by an animal. Therefore it is important that the bolus is at room temperature (15 - 20"C) prior to administration to prevent the development of fine cracks that may change the activity of the bolus.
To minimise the risk of regurgitation, avoid rough handling of animals after dosing.
No adverse effects have been observed in cattle administered three times the recommended dosage over a two-day period. Clinical signs of copper toxicity, which normally will only occur in cases of severe copper overdosage include jaundice, malaise,an acute drop in mild yield and later,haemoglobinuria. Signs of selenium toxicity include CNS changes,muscle weakness, vomiting, anorexia, depression, incoordination and later respiratory problems. In these circumstances intravenous administration of copper and/or selenium chelating agents such as ammonium tetrathiomolybdate or EDTA (ethylendiaminetetraacetic acid) are sometimes recommended. Ammonium tetrathiomolybdate (ATTP) is often quoted in veterinary literature as an antidote to copper poisoning. ATTP is not an authorized veterinary medicine.Any pharmacologically active substances used in a veterinary medicinal product administered to a food-producing animal under the cascade must be listed in Annex I , II or III to Council Regulation (EEC) No 2377/90. As ATTP does not appear in any of these Annexes it should not be administered to an animal intended for food production.
Cattle: Meat zero days; milk zero hours.
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