Ketoprofen is a non-steroidal anti-inflammatory drug belonging to the 2-arylpropionic acid group of NSAIDs. In addition to the anti-inflammatory effect, it also has an anti-pyretic and analgesic effect.
Comforion Vet is indicated for the anti-inflammatory and analgesic treatment of musculoskeletal disorders, and the alleviation of visceral pain associated with colic.
Comforion Vet is indicated for the anti-inflammatory and analgesic treatment of mammary gland disorders. Reduction of pyrexia associated with respiratory disease in conjunction with antimicrobial treatment .
Comforion Vet is indicated for the reduction of pyrexia in respiratory tract disorders and supportive treatment of post-partum dysgalactiae syndrome (MMA-syndrome - mastitis, metritis, agalactia) in conjunction with antibiotic therapy.
Dosage and administration
Horses: 2.2 mg ketoprofen/kg bodyweight (11 ml/500 kg bodyweight) per day by IV injection for up to 3 days. When used in equine colic, following administration of a dose, a subsequent dose may be given only after a thorough re-examination.
Cattle: 3 mg ketoprofen/kg bodyweight (3 ml/100 kg bodyweight) per day by IV or deep IM injection for up to 3 days.
Pigs: 3 mg ketoprofen/kg bodyweight (3 ml/100 kg bodyweight) per day by deep IM injection for up to 3 days.
Contra-indications, warnings, etc
Do not administer to horses, cattle or pigs that have a hypersensitivity to ketoprofen or any of the excipients in the product.
Use is contra-indicated in animals suffering from severe hepatic, renal or cardiac insufficiency, gastro-intestinal ulceration, heavy bleeding or evidence of blood dyscrasia.
Use with caution in dehydrated or hypotensive animals.
Other NSAIDs should not be used concomitantly or within 24 hours from administration of the product. Competition at plasma protein binding sites may lead to intoxication. Concurrent administration with diuretics, anticoagulant therapy and nephrotoxic drugs should be avoided.
Repeated intramuscular injections may cause mild transient irritation. Due to the mechanism of action of ketoprofen (inhibition of prostaglandin synthesis), gastric and intestinal irritation or ulceration or renal intolerance may occur.
Avoid intra-arterial injections.
Do not exceed the recommended dose or duration of treatment.
The use of ketoprofen is not recommended in foals under the age of 15 days. Use in any animal less than 6 weeks of age or in aged animals may involve additional risk. If such use cannot be avoided, animals may require a reduced dosage and careful management.
The safety of ketoprofen has been investigated in pregnant laboratory animals (rats, mice, rabbits) and cattle. No adverse effects were noted. As the safety of ketoprofen has not been assessed in pregnant mares or sows, the product should be used in these cases only according to the benefit/risk assessment by the responsible veterinarian.
Do not mix with other veterinary medicinal products.
Meat and offal: 4 days. Milk: zero hours.
Ketoprofen is a prohibited substance under international equine competition rules. Treatment with Comforion Vet should be stopped for a suitable time prior to competing.
Avoid splashes to the skin and eyes. If accidental skin or eye contact occurs, irrigate thoroughly with water. In case of accidental self-injection, seek medical advice.
Wash hands after use.
For animal treatment only. Keep out of the reach and sight of children
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